Targeting lipid metabolism in metastatic prostate cancer

Scheinberg, Tahlia; Mak, Blossom; Butler, Lisa M.; Selth, Luke A.; Horvath, Lisa G.

doi:10.1177/17588359231152839

Cited by 18 publications

(8 citation statements)

References 249 publications

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“…Scheinberg et al summarized the relationship between dietary fat intake and the risk of PCa and found contradicting results from various studies. Possible mechanisms by which fat intake increases the occurrence of PCa include the effects on hormone regulation and androgen levels, oxidative stress, inflammation, exposure to toxic pesticides, and the effects of specific fatty acids 78 . Another review suggested that reducing red meat and saturated fat intake could prevent PCa.…”

Section: Some Elements That Indirectly (Through Ppat) or Directly Aff...mentioning

confidence: 99%

“…Similar trends were observed for aggressive disease and death. However, these studies could not reproduce each other's findings because it is difficult to compare between trials owing to differences in study methods, assays, and metabolites examined 78 . Overall, these results suggested that PPAT-related genomic and lipid metabolomic profiles have critical potential applications for diagnostic applications.…”

Section: Ppat Provides New Perspectives For Diagnosing and Treating P...mentioning

confidence: 99%

“…In addition to statins, PCSK9 regulates cholesterol metabolism by attaching to the low-density lipoprotein (LDL) receptor and reducing LDL receptor-mediated removal from circulation 117 . Based on the current findings, lipid-targeting agents are unlikely to replace highly effective therapies in metastatic PCa; however, they can be combined to improve patient survival 78 .…”

Section: Ppat Provides New Perspectives For Diagnosing and Treating P...mentioning

confidence: 99%

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Periprostatic Adipose Tissue: A New Perspective for Diagnosing and Treating Prostate Cancer

Cao,

Wang,

Zhang

et al. 2024

J. Cancer

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Prostate cancer (PCa) is the most common tumor of the male genitourinary system. It will eventually progress to fatal metastatic castration-resistant prostate cancer, for which treatment options are limited. Adipose tissues are distributed in various parts of the body. They have different morphological structures and functional characteristics and are associated with the development of various tumors. Periprostatic adipose tissue (PPAT) is the closest white visceral adipose tissue to the prostate and is part of the PCa tumor microenvironment. Studies have shown that PPAT is involved in PCa development, progression, invasion, and metastasis through the secretion of multiple active molecules. Factors such as obesity, diet, exercise, and organochlorine pesticides can affect the development of PCa indirectly or directly through PPAT. Based on the mechanism of PPAT's involvement in regulating PCa, this review summarized various diagnostic and therapeutic approaches for PCa with potential applications to assess the progression of patients' disease and improve clinical outcomes.

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Section: Some Elements That Indirectly (Through Ppat) or Directly Aff...mentioning

confidence: 99%

Section: Ppat Provides New Perspectives For Diagnosing and Treating P...mentioning

confidence: 99%

Section: Ppat Provides New Perspectives For Diagnosing and Treating P...mentioning

confidence: 99%

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Periprostatic Adipose Tissue: A New Perspective for Diagnosing and Treating Prostate Cancer

Cao,

Wang,

Zhang

et al. 2024

J. Cancer

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“…Statins are currently the primary treatment agents for aberrant lipid metabolism; however, it is uncertain whether the use of statins increases the risk of developing PCa (153). Some studies (154)(155)(156)(157) have demonstrated that there is no association between statin use and the risk of developing PCa, while other studies (158)(159)(160) have indicated that statin use reduces the risk of developing advanced PCa and the risk of fatal PCa.…”

Section: Lipid Metabolism and The Diagnosis And Treatment Of Prostate...mentioning

confidence: 99%

New insights into lipid metabolism and prostate cancer (Review)

et al. 2023

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Prostate cancer (PCa) is the most common malignant tumor of the male urological system and poses a severe threat to the survival of middle-aged and elderly males worldwide. The development and progression of PCa are affected by a variety of biological processes, including proliferation, apoptosis, migration, invasion and the maintenance of membrane homeostasis of PCa cells. The present review summarizes recent research advances in lipid (fatty acid, cholesterol and phospholipid) metabolic pathways in PCa. In the first section, the metabolism of fatty acids is highlighted, from formation to catabolism and associated proteins. Subsequently, the role of cholesterol in the pathogenesis and evolution of PCa is described in detail. Finally, the different types of phospholipids and their association with PCa progression is also discussed. In addition to the impact of key proteins of lipid metabolism on PCa growth, metastasis and drug resistance, the present review also summarizes the clinical value of fatty acids, cholesterol and phospholipids, as diagnostic and prognostic indicators and therapeutic targets in PCa. Contents1. Introduction 2. Fatty acid metabolism in prostate cancer 3. Cholesterol and its ester metabolism in prostate cancer 4. Phospholipid metabolism in prostate cancer 5. Lipid metabolism and the diagnosis and treatment of prostate cancer 6. Conclusions and future perspectives

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“…Specifically, alterations in lipid metabolism can promote tumor cell growth, invasion, and metastasis, and regulate the characteristics of the tumor microenvironment through intracellular signaling pathways ( 9 , 10 ). Changes in lipid metabolism have been confirmed to be associated with tumor growth and treatment response in various cancers, including colorectal cancer, pancreatic cancer, and prostate cancer ( 11 - 13 ). However, the alterations in lipid metabolism in GC and whether these changes can serve as prognostic biomarkers have not been fully investigated.…”

Section: Introductionmentioning

confidence: 99%

APOA1 mRNA and serum APOA1 protein as diagnostic and prognostic biomarkers in gastric cancer

Li,

Han,

Gao

et al. 2024

Transl Cancer Res

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Background Gastric cancer (GC) remains a formidable challenge in oncology, ranking as a leading cause of cancer mortality globally. This underscores an urgent need for innovative prognostic markers that can revolutionize patient management and outcomes. Recent insights into cancer biology have spotlighted the profound influence of lipid metabolism alterations on tumorigenesis, tumor progression, and the tumor microenvironment. These alterations not only fuel cancer cell growth and proliferation but also play a strategic role in evading immune surveillance and promoting metastasis. The intricate web of lipid metabolism in cancer cells, characterized by deregulated uptake, synthesis, and oxidation of fatty acids (FAs), opens new avenues for targeted therapeutic interventions and prognostic evaluations. Specifically, this study zeroes in on apolipoprotein A-I ( APOA1 ), a key player in lipid metabolism, to unearth its prognostic value in GC. By delving into the role of lipid metabolism-related genes, particularly APOA1 , we aim to unveil their potential as groundbreaking biomarkers for GC prognosis. This endeavor not only aims to enhance our understanding of the molecular underpinnings of GC but also to spearhead the development of lipid metabolism-based strategies for improved diagnostic, prognostic, and therapeutic outcomes. Methods Transcriptomic and clinical data from GC patients and healthy individuals were sourced from The Cancer Genome Atlas (TCGA) database, a comprehensive project that molecularly characterizes over 20,000 primary cancer and matched normal samples across 33 cancer types. Significantly differentially expressed lipid metabolism-related genes were identified using the “limma” package in R. Prognostic genes were selected via univariate Cox regression analysis. Differential gene enrichment analysis was performed using Metascape ( http://www.metascape.org ). The Human Protein Atlas (HPA, https://www.proteinatlas.org ) provided information on APOA1 protein expression in GC and healthy tissues. Immune cell infiltration was analyzed using the CIBERSORT algorithm ( http://cibersort.stanford.edu ). Results Significant differences in lipid metabolism-related gene expression were observed between GC and normal tissues, closely linked to FA metabolism, oxidoreductase activity, and sphingolipid metabolism. APOA1 emerged as a potential prognostic biomarker by intersecting prognostic and differentially expressed lipid metabolism genes. Immunohistochemical analysis confirmed APOA1 downregulation in GC. The receiver operating characteristic (ROC) analysis demonstrated its predictive value, with the area under the curve (AUC) being 0.64 [95% confidence interval (CI): 0.52–0.76]. APOA1 expression correlated with immune cell ...

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Targeting lipid metabolism in metastatic prostate cancer

Cited by 18 publications

References 249 publications

Periprostatic Adipose Tissue: A New Perspective for Diagnosing and Treating Prostate Cancer

Periprostatic Adipose Tissue: A New Perspective for Diagnosing and Treating Prostate Cancer

New insights into lipid metabolism and prostate cancer (Review)

APOA1 mRNA and serum APOA1 protein as diagnostic and prognostic biomarkers in gastric cancer

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