Targeting long non coding RNA by natural products: Implications for cancer therapy

Homayoonfal, Mina; Asemi, Zatollah; Yousefi, Bahman

doi:10.1080/10408398.2021.2001785

Cited by 7 publications

(6 citation statements)

References 277 publications

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“…Natural products and their derivatives have various potent biological activities such as anticancer, anti-inflammatory, pro-apoptotic, and antioxidant characteristics, with the potential for chemotherapies and chemo-preventions for several cancers. They show anticancer effects primarily through epigenetic change, regulation of signaling pathways, and miRNA regulation in cancer cells or tissues ( Homayoonfal et al, 2021 ). Below we introduce several practical natural products employed in cancer treatment targeting lncRNAs introduced previously ( Table 2 ).…”

Section: Targeting Lncrnas With Natural Products For Potential Crc Tr...mentioning

confidence: 99%

Targeting lncRNAs of colorectal cancers with natural products

Sung

Hong

2023

Front. Pharmacol.

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Non-coding RNA (ncRNA) is one of the functional classes of RNA that has a regulatory role in various cellular processes, such as modulation of disease onset, progression, and prognosis. ncRNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have been actively studied in recent years. The change in ncRNA levels is being actively studied in numerous human diseases, especially auto-immune disorders and cancers; however, targeting and regulating ncRNA with natural products to cure cancer has not been fully established. Recently many groups reported the relationship between ncRNA and natural products showing promising effects to serve as additional therapeutic approaches to cure cancers. This mini-review summarizes the aspects of lncRNAs related to cancer biology focusing on colorectal cancers that natural products can target.

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Section: Targeting Lncrnas With Natural Products For Potential Crc Tr...mentioning

confidence: 99%

Targeting lncRNAs of colorectal cancers with natural products

Sung

Hong

2023

Front. Pharmacol.

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“…In recent decades, several reports have shown that lncRNAs (Yin et al, 2018;Diniz et al, 2021;Homayoonfal et al, 2021) play important roles in tumor progression and could be biomarkers for clinical treatments. Increasing studies have demonstrated that DUXAP10 is involved in the tumorigenesis and development of tumors through the modulation of diverse cellular processes, comprising cell colony formation, cell cycle progression, cell proliferation, apoptosis, metastasis, and even CSC-like properties.…”

Section: Duxap10 As a Treatment Targetmentioning

confidence: 99%

“…Long noncoding RNAs (Zhu et al, 2013;Rathinasamy and Velmurugan, 2018;Zheng et al, 2021;Ma et al, 2022) (lncRNAs) represent a special type of non-coding RNA with more than 200 nucleotides that are not translated into proteins. The aberrant expression of lncRNAs has been frequently observed in a variety of diseases, including human malignancies (Isin and Dalay, 2015;Bhan et al, 2017;Bian et al, 2021;Homayoonfal et al, 2021;Liu and Lei, 2021). Moreover, an increasing number of studies have shown that lncRNAs are involved in the pathogenesis and development of many cancers and are associated with different clinicopathological features (Wang et al, 2021b;Dong et al, 2021;Ma et al, 2021;Zhou et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

The LncRNA DUXAP10 Could Function as a Promising Oncogene in Human Cancer

Zhao

Dong

et al. 2022

Front. Cell Dev. Biol.

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Cancer is one of the most prevalent and deadliest diseases globally, with an increasing morbidity of approximately 14 million new cancer cases per year. Identifying novel diagnostic and prognostic biomarkers for cancers is important for developing cancer therapeutic strategies and lowering mortality rates. Long noncoding RNAs (lncRNAs) represent a group of noncoding RNAs of more than 200 nucleotides that have been shown to participate in the development of human cancers. The novel lncRNA DUXAP10 was newly reported to be abnormally overexpressed in several cancers and positively correlated with poor clinical characteristics of cancer patients. Multiple studies have found that DUXAP10 widely regulates vital biological functions related to the development and progression of cancers, including cell proliferation, apoptosis, invasion, migration, and stemness, through different molecular mechanisms. The aim of this review was to recapitulate current findings regarding the roles of DUXAP10 in cancers and evaluate the potential of DUXAP10 as a novel biomarker for cancer diagnosis, treatment, and prognostic assessment.

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“…Long non-coding RNA (lncRNA) are RNA molecules that comprise >200 nucleotides that lack or have limited coding ability [ 4 , 5 ]. Accumulating research shows that lncRNAs are important regulatory factors for multiple biological functions and perform a fundamental function in tumor proliferation, invasion, metastasis, and metabolic process [ [6] , [7] , [8] ].…”

Section: Introductionmentioning

confidence: 99%

METTL3/YTHDC1-mediated upregulation of LINC00294 promotes hepatocellular carcinoma progression

Zhang,

Yang,

Huang

et al. 2023

Heliyon

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Targeting long non coding RNA by natural products: Implications for cancer therapy

Cited by 7 publications

References 277 publications

Targeting lncRNAs of colorectal cancers with natural products

Targeting lncRNAs of colorectal cancers with natural products

The LncRNA DUXAP10 Could Function as a Promising Oncogene in Human Cancer

METTL3/YTHDC1-mediated upregulation of LINC00294 promotes hepatocellular carcinoma progression

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