Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy

Wang, Qin; Jiang, Hao; Li, Yan; Chen, Wenfei; Li, Hanmei; Peng, Ke; Zhang, Zhirong; Sun, Xun

doi:10.1016/j.biomaterials.2017.01.008

Cited by 184 publications

(110 citation statements)

References 38 publications

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“…Recently, several delivery systems based on PEI development for cancer treatment have been introduced [61]. Nanocarriers have an important role in delivery of drug-gene combinations to cancer cells [62].…”

Section: Applications Of Peimentioning

confidence: 99%

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Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon

Zakeri

Kouhbanani

Beheshtkhoo

et al. 2018

Nano Reviews & Experiments

234

150

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The meaning of gene therapy is the delivery of DNA or RNA to cells for the treatment or prevention of genetic disorders. The success rate of gene therapy depends on the progression and safe gene delivery system. The vectors available for gene therapy are divided into viral and non-viral systems. Viral vectors cause higher transmission efficiency and long gene expression, but they have major problems, such as immunogenicity, carcinogenicity, the inability to transfer large size genes and high costs. Non-viral gene transfer vectors have attracted more attention because they exhibit less toxicity and the ability to transfer large size genes. However, the clinical application of non-viral methods still faces some limitations, including low transmission efficiency and poor gene expression. In recent years, numerous methods and gene-carriers have been developed to improve gene transfer efficiency. The use of Polyethylenimine (PEI) based transfer of collaboration may create a new way of treating diseases and the combination of chemotherapy and gene therapy. The purpose of this paper is to introduce the PEI as an appropriate vector for the effective gene delivery.

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Section: Applications Of Peimentioning

confidence: 99%

“…(Table 1). PEI based co-delivery, may be presented a new method for treating diseases by combination of chemotherapy and gene therapy [61]. …”

Section: Applications Of Peimentioning

confidence: 99%

Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon

Zakeri

Kouhbanani

Beheshtkhoo

et al. 2018

Nano Reviews & Experiments

234

150

View full text Add to dashboard Cite

show abstract

“…In a recent study, Sun and coworkers used polymeric hybrid micelles to simultaneously deliver dexamethasone and siRNA against NF‐κB for arthritis therapy. The co‐delivery hybrid micelles reduced the inflammation effectively by transforming the M1 macrophages to M2 state . In addition to the drug conjugation and drug‐loaded nanocarriers, fullerenes as the third allotrope of carbon have been exploited as innovative therapeutic NMs that can also inhibit inflammation by reducing the level of reactive oxygen species (ROS) and blunting the NF‐κB signaling pathway .…”

Section: Targeting Nms Relieve the Att Of Ramentioning

confidence: 99%

Move to Nano‐Arthrology: Targeted Stimuli‐Responsive Nanomedicines Combat Adaptive Treatment Tolerance (ATT) of Rheumatoid Arthritis

Liu

Guo

Liang

2018

Biotechnology Journal

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Rheumatoid arthritis (RA) is one of the most popular chronic autoimmune diseases characterized with persistent synovial inflammation and bone destruction. Although considerable developments have been gained in clinical treatment of RA, the major drawback to RA therapy stems from the adaptive treatment tolerance (ATT) following the long-term drug use, which causes compromised efficacy, sustained drug dose increase, and severe adverse events. To address these challenges, it is of great significance to put forward innovative therapeutic approaches for RA treatment. Nowadays, developments of nanotechnology-based nanomedicines (NMs) for RA are in progress. Multifunctional NMs with targeted stimuli-responsive features have been one of the central concepts in designing more accessible formulations for efficient RA treatment. These NMs are able to postpone RA progression effectively, because of their delivery and on-demand release of medicaments at targeted sites in response to external or internal stimuli related to the RA pathophysiology without obvious adverse side-effects on the normal tissues. Therefore, NMs have gained interest from pre-clinical research scientists as well as clinical doctors worldwide. Herein, the authors highlight the recent attempts of targeted stimuli-responsive NMs for RA therapy in the last 5 years. The described progresses may pave the way to novel and highly effective RA NMs.

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“…The treatment of autoimmune diseases usually involves different classes of immunosuppressive drugs (Her and Kavanaugh, 2016). Glucocorticoids inhibit the function of immune cells as the activated glucocorticoid receptor directly interferes with the transcription factors NF-kB and AP-1 (van der Laan and Meijer, 2008;Frenkel et al, 2015;Wang et al, 2017). Glucocorticoids are quite effective, but this potency is accompanied by a range of side effects (Ramamoorthy and Cidlowski, 2016).…”

Section: Introductionmentioning

confidence: 99%

Immunosuppressive Activity of Artemisia argyi Extract and Isolated Compounds

et al. 2020

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The need for novel drugs for the treatment of autoimmune diseases is high, since available pharmaceuticals often have substantial side effects and limited efficacy. Natural products are a good starting point in the development of immunosuppressive leads. Since enhanced T cell proliferation is a common feature of autoimmune diseases, we investigated the T cell proliferation inhibitory potential of an extract library of plants used in traditional Chinese medicine. Using a newly established cell-based screening platform, an ethyl acetate extract of Artemisia argyi H.Lév. & Vaniot (Asteraceae, A. argyi) was found to suppress the proliferation of human primary T lymphocytes in vitro in an IL-2-dependent manner. Flow cytometry-and ELISA-based techniques further demonstrated that the A. argyi extract reduced the activation and function of T cells. Transcription factor analysis and flow cytometric calcium influx investigations indicated that the immunomodulatory effect was based on specific modification of T cell signaling in a non-cytotoxic manner which is mediated via the NFAT pathway and a non-sequestrant inhibition of the calcium influx. A series of guaianolide and seco-guaianolide sesquiterpene lactones, as well as a flavonoid, were identified in a previous study as the bioactive compounds in the A. argyi extract. The effects of these bioactive compounds were compared to those of the crude extract. The tested sesquiterpene lactones act via the transcription factor NFAT and NF-kB, thereby exhibiting their immunosuppressive potential, but have an overall effect on T cell biology on a more-downstream level than the crude A. argyi extract.

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Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy

Cited by 184 publications

References 38 publications

Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon

Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon

Move to Nano‐Arthrology: Targeted Stimuli‐Responsive Nanomedicines Combat Adaptive Treatment Tolerance (ATT) of Rheumatoid Arthritis

Immunosuppressive Activity of Artemisia argyi Extract and Isolated Compounds

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