Targeting of stress response pathways in the prevention and treatment of cancer

Zelenka, Jaroslav; Koncošová, Martina; Ruml, Tomáš

doi:10.1016/j.biotechadv.2018.01.007

Cited by 44 publications

(42 citation statements)

References 284 publications

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“…The metabolic stress response network includes a number of regulatory enzymes and transcription factors (e.g. AMPK, HIFα, PGC1α), providing a wide variety of options for pharmaceutical targeting . For example, in the case of MYC‐induced metabolic stress, inhibitors of glutaminase and lactate dehydrogenase have been shown to suppress tumor growth by blocking the flux of the nutrients required for cancer cell proliferation in response to upregulated MYC activity .…”

Section: Metabolic Stressmentioning

confidence: 99%

“…Uncovering the molecular mechanisms by which plants and microorganisms respond to stresses will help us to better understand biological evolution . Insights from these studies could impact a wide variety of fields, ranging from the identification of phenotypic traits to improve crop tolerance to extreme conditions, to the design of more effective therapeutic strategies for cancer …”

Section: Introductionmentioning

confidence: 99%

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Therapeutic targeting of cellular stress responses in cancer

Chen

Xie

2018

Thoracic Cancer

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Similar to bacteria, yeast, and other organisms that have evolved pathways to respond to environmental stresses, cancer cells develop mechanisms that increase genetic diversity to facilitate adaptation to a variety of stressful conditions, including hypoxia, nutrient deprivation, exposure to DNA‐damaging agents, and immune responses. To survive, cancer cells trigger mechanisms that drive genomic instability and mutation, alter gene expression programs, and reprogram the metabolic pathways to evade growth inhibition signaling and immune surveillance. A deeper understanding of the molecular mechanisms that underlie the pathways used by cancer cells to overcome stresses will allow us to develop more efficacious strategies for cancer therapy. Herein, we overview several key stresses imposed on cancer cells, including oxidative, metabolic, mechanical, and genotoxic, and discuss the mechanisms that drive cancer cell responses. The therapeutic implications of these responses are also considered, as these factors pave the way for the targeting of stress adaption pathways in order to slow cancer progression and block resistance to therapy.

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Section: Metabolic Stressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic targeting of cellular stress responses in cancer

Chen

Xie

2018

Thoracic Cancer

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“…Autophagy is a highly conserved ‘self-devouring’ process that ensures the orderly degradation of the cytoplasmic contents and the recycling of the macromolecular constituents to maintain cellular homeostasis ( 11 ). Considering the fundamental roles of autophagy in regulating cellular biological processes, it is no surprise that it plays essential roles in a wide spectrum of physiological conditions and diseases, particularly cancer ( 12 – 15 ). Moreover, exploring the potential mechanisms of action of autophagy would not only expose the mysterious veil of tumorigenesis, but may also aid in the identification of novel therapeutic targets for autophagy in cancer ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of the clinical significance and prospective molecular mechanisms of differentially expressed autophagy-related genes in thyroid cancer

Lin

Wen

et al. 2018

Int J Oncol

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Thyroid cancer (TC) is the most common endocrine malignancy, accounting for approximately 90% of all malignancies of the endocrine system. Despite the fact that patients with TC tend to have good prognoses, the high incidence rate and lymph node metastases remain unresolved issues. Autophagy is an indispensable process that maintains intracellular homeostasis; however, the role of autophagy in several steps of the initiation and progression of TC has not yet been elucidated. In this study, we first identified several autophagy-related genes (ARGs) that were provoked in the onset of TC. Subsequently, a bioinformatics analysis hinted that these genes were markedly disturbed in several proliferative signaling pathways. Moreover, we demonstrated that the differentially expressed ARGs were closely related to several aggressive clinical manifestations, including an advanced tumor stage and lymph node metastasis. Our study further selected prognostic ARGs and developed a prognostic signature based on three key genes (ATG9B, BID and B1DNAJB1), which displayed a moderate ability to predict the prognosis of TC. On the whole, the findings of this study demonstrate that ARGs disrupt proliferation-related pathways and consequently lead to aggressive clinical manifestations. These findings provide insight into the potential molecular mechanisms of action of ARGs and their clinical significance, and also provide classification information of potential therapeutic significance.

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“…This would then provide the protection against biological stresses affecting normal homeostasis of tissues and cells and that can intervene in tumorigenesis, whether genetic or epigenetic. To paraphrase the summary statements in the review article on stress response by Zelenka et al [84] they indicate the following. Upregulation of the cellular stress response pathways are governed by exercise, natural compounds, or drugs that protect the body against carcinogenesis.…”

Section: Hormetic Effects May Govern the Efficacy Of Phytochemicals Amentioning

confidence: 99%

Perspective on dietary isothiocyanates in the prevention, development and treatment of cancer

Yeger¹,

Mokhtari²

2020

JCMT

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Epidemiological evidence has highlighted the association of specific diets and a lower incidence of cancer. Foremost, the Mediterranean diet provides high levels of polyphenolics and a high consumption of healthier fats, e.g., as from olive oil. In the Mediterranean region the consumption of vegetables is elevated providing a class of compounds, the isothiocyanates (ITCs) as found in the cabbage family. The ITCs have raised great interest for their health benefits over the past few decades. Some of the key ITC compounds, sulforaphane, phenethylisothiocyanate and benzyl isothiocyanate, have been studied in vitro and in vivo and the data support their promise for cancer chemoprevention, as anti-tumor agents, and for chemoprotection of normal tissues and organs. Along with other polyphenolic compounds in the diet, in general, they also possess key anti-inflammatory properties thus satisfying the criteria for compounds that could intervene in cancer initiation and progression. In this review we provide a larger overview of the advantages of including ITCs in the diet as food or as supplements and speculate on what could constitute a valuable therapeutic strategy for improving and sustaining good health and countering cancer disease in humans.

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Targeting of stress response pathways in the prevention and treatment of cancer

Cited by 44 publications

References 284 publications

Therapeutic targeting of cellular stress responses in cancer

Therapeutic targeting of cellular stress responses in cancer

Comprehensive analysis of the clinical significance and prospective molecular mechanisms of differentially expressed autophagy-related genes in thyroid cancer

Perspective on dietary isothiocyanates in the prevention, development and treatment of cancer

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