Targeting of the tumor microenvironment by curcumin

Fu, Xiao; He, Yingni; Huang, Zezhi; Najafi, Masoud

doi:10.1002/biof.1776

Cited by 48 publications

(20 citation statements)

References 154 publications

(158 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The TME is formed by these components and their complex interaction with one another. The various cellular compartments that make up the TME are able to critically regulate tumorigenesis, which is essential not only to tumor initiation, malignant progression, and metastasis but also to response to therapy [ 34 , 35 ]. In the TME, the majority of host cells that are drawn to and activated are immune cells.…”

Section: Discussionmentioning

confidence: 99%

KDELR3 Is a Prognostic Biomarker Related to the Immune Infiltration and Chemoresistance of Anticancer Drugs in Uveal Melanoma

Zhang

Guan

et al. 2022

Disease Markers

View full text Add to dashboard Cite

Uveal melanoma (UM) is an intraocular malignancy in adults in which approximately 50% of patients develop metastatic diseases and have a poor clinical outcome. Immunotherapies are quickly becoming a need, and recent research has produced some amazing achievements in this area. In the current investigation, an attempt was made to evaluate the prognostic usefulness of KDELR3 in UM, particularly its connection with tumor-infiltrating lymphocytes (TILs). The expression patterns of mRNAs and related clinical data of 80 UM patients were obtained from The Cancer Genome Atlas (TCGA). By using RT-PCR, we were able to investigate whether or not UM cells and D78 cells expressed KDELR3. The Kaplan-Meier approach, as well as univariate and multivariate tests, was utilized in order to investigate the potential predictive significance of KDELR3 expression. The associations between KDELR3 and TILs and immunological checkpoints were analyzed in order to evaluate the effect that KDELR3 may have on UM immunotherapy. On the basis of the differential expression of KDELR3, a distribution of the half-maximal inhibitory concentration (IC50) of various targeted medicines was observed. In this study, we found that the expression of KDELR3 was distinctly increased in most types of tumors. In addition, KDELR3 was highly expressed in UM cells. Moreover, patients with high KDELR3 expression exhibited a shorter overall survival and disease-free survival than those with low KDELR3 expression. Multivariate analyses confirmed that KDELR3 expression was an independent prognostic factor for overall survival and disease-free survival in patients with UM. Furthermore, KDELR3 expression was demonstrated to be positively correlated with macrophage M1, T cell CD8, T cell follicular helper, dendritic cell resting, and T cell CD4 memory activated. Meanwhile, the expression of KDELR3 was related to several immune checkpoints. The IC50 of AP-24534, BHG712, bleomycin, camptothecin, cisplatin, cytarabine, GSK1070916, and tipifarnib was higher in the KDELR3 high-expression group. In conclusion, KDELR3 may be applied as a potential diagnostic and prognostic biomarker for UM patients.

show abstract

Section: Discussionmentioning

confidence: 99%

KDELR3 Is a Prognostic Biomarker Related to the Immune Infiltration and Chemoresistance of Anticancer Drugs in Uveal Melanoma

Zhang

Guan

et al. 2022

Disease Markers

View full text Add to dashboard Cite

show abstract

“…On the one hand, antitumor cells such as NK cells and cytotoxic T lymphocytes (CTLs, mainly CD8+ T cells) can identify and eliminate cancer cells. They play a role in cancer immune monitoring ( 21 – 23 ). On the other hand, immunosuppressive cells such as regulatory T cells (Tregs), TAMs, and myeloid-derived suppressor cells (MDSCs) protect cancer cells by evading immune surveillance.…”

Section: Timementioning

confidence: 99%

“…On the other hand, immunosuppressive cells such as regulatory T cells (Tregs), TAMs, and myeloid-derived suppressor cells (MDSCs) protect cancer cells by evading immune surveillance. Subsequently, cancer cells can continue to invade, metastasize and induce angiogenesis ( 21 – 23 ). At the same time, cancer cells can induce, expand and recruit a large number of tumor-promoting myeloid cells to establish a tumor immunosuppressive microenvironment by driving immunosuppression, regulating the generation of immune cell subtypes ( 21 , 22 ).…”

Section: Timementioning

confidence: 99%

Regulation of dietary polyphenols on cancer cell pyroptosis and the tumor immune microenvironment

et al. 2022

View full text Add to dashboard Cite

Cancer is a major public health problem that threatens human life worldwide. In recent years, immunotherapy has made great progress in both clinical and laboratory research. But the high heterogeneity and dynamics of tumors makes immunotherapy not suitable for all cancers. Dietary polyphenols have attracted researchers' attention due to their ability to induce cancer cell pyroptosis and to regulate the tumor immune microenvironment (TIME). This review expounds the regulation of dietary polyphenols and their new forms on cancer cell pyroptosis and the TIME. These dietary polyphenols include curcumin (CUR), resveratrol (RES), epigallocatechin gallate (EGCG), apigenin, triptolide (TPL), kaempferol, genistein and moscatilin. New forms of dietary polyphenols refer to their synthetic analogs and nano-delivery, liposomes. Studies in the past decade are included. The result shows that dietary polyphenols induce pyroptosis in breast cancer cells, liver cancer cells, oral squamous cells, carcinoma cells, and other cancer cells through different pathways. Moreover, dietary polyphenols exhibit great potential in the TIME regulation by modulating the programmed cell death protein 1(PD-1)/programmed death-ligand 1 (PD-L1) axis, enhancing antitumor immune cells, weakening the function and activity of immunosuppressive cells, and targeting tumor-associated macrophages (TAMs) to reduce their tumor infiltration and promote their polarization toward the M1 type. Dietary polyphenols are also used with radiotherapy and chemotherapy to improve antitumor immunity and shape a beneficial TIME. In conclusion, dietary polyphenols induce cancer cell pyroptosis and regulate the TIME, providing new ideas for safer cancer cures.

show abstract

“…Curcumin and resveratrol are plant-derived polyphenolic compounds reported to exhibit therapeutic properties, including anti-inflammatory, antioxidant, and anticancer activities. , Curcumin has been shown to inhibit cancer cell proliferation and induced apoptosis in numerous cancer cell types. − Similar to curcumin, resveratrol also inhibits carcinogenesis. , Importantly, both curcumin and resveratrol target cancer cells , and particularly impact cancer cells’ mitochondria. , Previous studies reported that curcumin and resveratrol decrease the mitochondrial membrane potential, , impair the activity of some mitochondrial respiratory enzymes, , and trigger mitochondrial outer membrane permeabilization (MOMP). , Interestingly, curcumin and resveratrol have displayed synergistic effects when administered in tandem. , Both curcumin and resveratrol, however, are hydrophobic, thus exhibiting low solubility in aqueous solutions and poor bioavailability which hinder their therapeutic applicability. Efforts toward increasing the therapeutic efficacy of curcumin and resveratrol have been accomplished by different methods, particularly their inclusion in varied delivery systems. , …”

Section: Introductionmentioning

confidence: 99%

“…6,7 Importantly, both curcumin and resveratrol target cancer cells 8,9 and particularly impact cancer cells' mitochondria. 10,11 Previous studies reported that curcumin and resveratrol decrease the mitochondrial membrane potential, 12,13 impair the activity of some mitochondrial respiratory enzymes, 14,15 and trigger mitochondrial outer membrane permeabilization (MOMP). 16,17 Interestingly, curcumin and resveratrol have displayed synergistic effects when administered in tandem.…”

Section: Introductionmentioning

confidence: 99%

Synergistic Activity of Anticancer Polyphenols Embedded in Amphiphilic Dendrimer Nanoparticles

Ben-Zichri

Meltzer

Lacham-Hartman

et al. 2022

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

Dendritic polymer nanoparticles (NPs) are promising vehicles for drug delivery. Most dendrimer polymer NPs, however, exhibit positive surface charge which make them, in many instances, cytotoxic. We constructed noncationic, amphiphilic dendrimer NPs embedding curcumin and resveratrol, natural polyphenols exhibiting anticancer properties. The curcumin/resveratrol/dendrimer NPs both effectively shielded the embedded polyphenols and facilitated their slow release and, notably, targeted cancer cells. The experimental data trace the cancer cell toxicity of the curcumin/resveratrol/dendrimer NPs to impairment of mitochondrial functions, specifically giving rise to enhanced intracellular calcium release, inhibition of cytochrome c oxidase enzyme activity, decreased mitochondrial membrane potential, and mitochondrial membrane perturbation. Importantly, synergism between the dendrimer-NP-embedded curcumin and resveratrol was observed, as more pronounced cancer cell death and mitochondrial disruption were induced by the curcumin/resveratrol/dendrimer NPs as compared to either the freely dissolved polyphenols or amphiphilic dendrimer NPs incorporating curcumin or resveratrol separately. This work suggests that amphiphilic dendrimer NPs encapsulating curcumin and resveratrol may constitute a promising anticancer therapeutic platform.

show abstract

Targeting of the tumor microenvironment by curcumin

Cited by 48 publications

References 154 publications

KDELR3 Is a Prognostic Biomarker Related to the Immune Infiltration and Chemoresistance of Anticancer Drugs in Uveal Melanoma

KDELR3 Is a Prognostic Biomarker Related to the Immune Infiltration and Chemoresistance of Anticancer Drugs in Uveal Melanoma

Regulation of dietary polyphenols on cancer cell pyroptosis and the tumor immune microenvironment

Synergistic Activity of Anticancer Polyphenols Embedded in Amphiphilic Dendrimer Nanoparticles

Contact Info

Product

Resources

About