2022
DOI: 10.3390/biom12020206
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Targeting Platelet Activation in Abdominal Aortic Aneurysm: Current Knowledge and Perspectives

Abstract: Abdominal aortic aneurysm (AAA) is a potentially fatal vascular disease that involves complex multifactorial hemodynamic, thrombotic, inflammatory, and aortic wall remodeling processes. However, its mechanisms are incompletely understood. It has become increasingly clear that platelets are involved in pathological processes of vascular diseases beyond their role in hemostasis and thrombosis. Platelet activation with membrane receptors and secreted mediators promotes thrombus formation and the accumulation of i… Show more

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Cited by 21 publications
(18 citation statements)
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References 105 publications
(117 reference statements)
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“…Lastly, from a purely speculative viewpoint, we could hypothesize that the increased incidence of refractory TIIEL in patients with CAD, as shown by the univariate analysis and the ANOVA test results ( Table 1 and Figure 1 ), could be related to an active thrombus remodeling after EVAR due to a more aggressive systemic atherosclerosis [ 27 ], involving plasmatic mediators [ 28 ]. Undoubtedly, this is only a research hypothesis that needs to be proved in further dedicated studies.…”
Section: Discussionmentioning
confidence: 99%
“…Lastly, from a purely speculative viewpoint, we could hypothesize that the increased incidence of refractory TIIEL in patients with CAD, as shown by the univariate analysis and the ANOVA test results ( Table 1 and Figure 1 ), could be related to an active thrombus remodeling after EVAR due to a more aggressive systemic atherosclerosis [ 27 ], involving plasmatic mediators [ 28 ]. Undoubtedly, this is only a research hypothesis that needs to be proved in further dedicated studies.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, two novel CCT diseases showed a significant association to PTS, and four novel CCT diseases showed a significant association to Notoginseng. These included Aortic Aneurysm (a dilation Herb-paths in the aorta which can be caused/aggravated by platelet aggregation 40 ); which might benefit from the anti-platelet treatment provided by Notoginseng/PTS 12,27 .…”
Section: Discussionmentioning
confidence: 99%
“…In recent years, many studies have tried establishing the role of activated platelets in the development and progression of AAA. Aside from their crucial role in thrombosis and hemostasis, a non-occlusive intraluminal thrombus (ILT) formation is known to contribute to the pro-inflammatory and prothrombotic backdrop of AAA (88)(89)(90). It was initially hypothesized that ILT could act as a protective mechanism to reduce mechanical stress induced on the vascular wall (91).…”
Section: Intraluminal Thrombus and Mechanosensing In Aaamentioning
confidence: 99%