Targeting selenium nanoparticles combined with baicalin to treat HBV-infected liver cancer

Fang, Xueyang; Xian-lin, WU; Li, Chang'e; Zhou, Binwei; Chen, Xiaoyin; Chen, Tianfeng; Yang, Fang

doi:10.1039/c6ra28229f

Cited by 31 publications

(27 citation statements)

References 40 publications

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“…Baicalin (7-D-glucuronic acid-5,6-dihydroxyflavone, purity > 95%) was purchased from Aladdin Company, Shanghai, China, and dissolved in polyethylene glycol (PEG, provided by Department of Chemistry, Jinan University, Guangzhou, China). As a kind of nontoxic solvent, PEG increased the solubility of baicalin [ 12 ], which also improved the bioavailability. Ribavirin (H51023508) was produced by Sichuan Baili Pharmaceutical Company, Sichuan, China.…”

Section: Methodsmentioning

confidence: 99%

Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis

Peng

Zheng

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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The objective of this study is to investigate the effects of baicalin on controlling the pulmonary infection and improving the prognosis in influenza A virus (IAV) infection. PCR and western blot were used to measure the changes of some key factors in RLRs signaling pathway. MSD electrochemiluminescence was used to measure the expression of pulmonary inflammatory cytokines including IFN-γ, TNF-α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p70, and KC/GRO. Flow cytometry was used to detect the proportion of Th1, Th2, Th17, and Treg. The results showed that IAV infection led to low body weight and high viral load and high expression of RIG-I, IRF3, IRF7, and NF-κB mRNA, as well as RIG-I and NF-κB p65 protein. However, baicalin reduced the rate of body weight loss, inhibited virus replication, and downregulated the key factors of the RLRs signaling pathway. Besides, baicalin reduced the high expression inflammatory cytokines in lung and decreased the ratios of Th1/Th2 and Th17/Treg to arouse a brief but not overviolent inflammatory response. Therefore, baicalin activated a balanced host inflammatory response to limit immunopathologic injury, which was helpful to the improvement of clinical and survival outcomes.

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Section: Methodsmentioning

confidence: 99%

Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis

Peng

Zheng

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Therefore, DDS conjugated with targeting ligands have been widely adopted in previous articles to increasing the tumor-homing capability while at the same time reducing the unwanted side effects of the modified DDS. [12,13] In the last decade, monoclonal antibodies capable of targeting corresponding receptors on cancer cell surface and exert corresponding functions are considered as promising chemotherapy candidates for effective cancer therapy. [14,15] Trastuzumab (Tra) is a commonly adopted monoclonal antibody that has high affinity to human epidermal growth factor receptor 2 (HER2) and inhibits its following signaling within cancer cells via specific binding.…”

Section: Introductionmentioning

confidence: 99%

Trastuzumab modified silica nanoparticles loaded with doxorubicin for targeted and synergic therapy of breast cancer

Meng

Ren

Meng

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Untargeted delivery as well as low efficacy are two main obstacles for effective breast cancer therapy. Here in this study, we surface modified silica nanoparticles (SLN) with Trastuzumab (Tra) to construct a tumor-targeting carrier (Tra-SLN) for specific drug delivery to human epidermal growth factor receptor 2 (HER2) overexpressing breast cancer cells. In addition, Tra-SLN could also loaded with broad-spectrum anticancer drug doxorubicin (DOX) to finally construct a drug delivery system (DDS) capable of co-delivering Tra and DOX (Tra-SLN/DOX). Our results demonstrated that the as-prepared Tra-SLN/DOX was nanoscale particles with spheroid appearance which showed preferable stability in physiological environments. In addition, the Tra-SLN/DOX could specifically target to HER2 overexpressed MCF-7 cells. Both in vitro and in vivo experiments revealed that the Tra-SLN/DOX exerted enhanced anticancer efficacy when compared with Tra or DOX alone. It was suggested that Tra-SLN/DOX might be a promising platform for enhanced therapy of breast cancer.

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“…The cells were cultured as described previously. 26 Cytotoxicity assay was also performed as previously reported. 26 The fluorescence images stained with calcein AM (green) and PI (red) and thermal images of MCF-7 cells with different treatments were taken by fluorescence microscopy (ZEISS Observer, Z1) and thermal imager, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…23 Selenium nanoparticles (SeNPs) have been studied and proposed as excellent nanomedicines for anti-tumor drugs and drug carrier because of their high anti-tumor activity, superior anti-oxidation, low toxicity to normal cells, and good biocompatibility and degradability. Chen's group [24][25][26][27] reported that SeNPs induced apoptosis in tumor cells by causing intracellular oxidative stress, mitochondrial dysfunction and simultaneous inhibition of cancer growth, migration and invasion. Kim's group 28 reported that silicacapped gold nanorods covered with Se coating (Se@Au@mSiO 2 /DOX) suppressed tumor cell growth by cell cycle arrest and induced apoptosis via suppression of the Src/FKA/AKT signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

<p>Multifunctional Nanotheranostic Gold Nanocage/Selenium Core-Shell for PAI-Guided Chemo-Photothermal Synergistic Therapy in vivo</p>

Fang¹,

Lui²,

Li³

et al. 2020

IJN

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Introduction Cancer theragnosis involving cancer diagnosis and targeted therapy simultaneously in one integrated system would be a promising solution of cancer treatment. Herein, a convenient and practical cancer theragnosis agent was constructed by combining gold nanocages (AuNCs) covered with selenium and a chitosan (CS) shell (AuNCs/Se) to incorporate the anti-cancer drug doxorubicin (DOX) as a multifunctional targeting nanocomposite (AuNCs/DOX@Se-iRGD) for photoacoustic imaging (PAI)-guided chemo-photothermal synergistic therapy that contributes to enhanced anti-cancer efficacy. The novel design of AuNCs/DOX@Se-iRGD gives the nanocomposite two outstanding properties: (1) AuNCs, with excellent LSPR property in the NIR region, act as a contrast agent for enhanced PAI and photothermal therapy (PTT); (2) Se acts as an anti-cancer nanoagent and drug delivery cargo. Methods The photothermal performance of these nanocomposites was evaluated in different concentrations with laser powder densities. These nanocomposites were also incubated in pH 5.3, 6.5, 7.4 PBS and NIR laser to study their drug release ability. The cellular uptake was studied by measuring the Se and Au concentrations inside the cells using inductively coupled plasma-mass spectrometry (ICP-MS). Besides, in vitro and in vivo anti-tumor activity were carried out by cytotoxicity assay MTT and tumor model nude mice, respectively. As for imaging, the PA value and images of these nanocomposites accumulated in the tumor site were sequentially collected at specific time points for 48 h. Results and Discussion The prepared AuNCs/DOX@Se-iRGD showed excellent biocompatibility and physiological stability in different media. In vivo results indicated that the targeting nanocomposite presented the strongest contrast-enhanced PAI signals, which could provide contour and location information of tumor, 24 h after intravenous injection. Likewise, the combined treatment of chemo- and photothermal synergistic therapy significantly inhibited tumor growth when compared with the two treatments carried out separately and showed negligible acute toxicity to the major organs. Conclusion This study demonstrates that AuNCs/DOX@Se-iRGD has great prospect to become a multifunctional anti-tumor nanosystem for PAI-guided chemo- and photothermal synergistic therapy.

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Targeting selenium nanoparticles combined with baicalin to treat HBV-infected liver cancer

Abstract: Herein, we demonstrate baicalin-loaded selenium nanoparticles with a liver-targeting folic acid moiety to treat HBV-infected liver cancer.

Cited by 31 publications

References 40 publications

Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis

Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis

Trastuzumab modified silica nanoparticles loaded with doxorubicin for targeted and synergic therapy of breast cancer

<p>Multifunctional Nanotheranostic Gold Nanocage/Selenium Core-Shell for PAI-Guided Chemo-Photothermal Synergistic Therapy in vivo</p>

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