Targeting Stress Responses for Regenerative Medicine

Milisav, Irina; Ribarič, Samo; Šuput, Dušan

doi:10.1007/978-1-4939-2522-3_17

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…During such conditions the cell either tries to retain its normal cellular homeostasis or tries to adapt to the conditions set by the stress on the cell. The cellular response may include (i) initiation of the repair mechanism using available resources, (ii) induction of temporary adaptive efforts with respect to the stressful conditions, (iii) may induce autophagy or (iv) initiation of process of cellular death [12]. Cellular repair mechanism involves change in gene expression, modulate the transcription under stressed conditions, controlled repair of quality protein, repair the damage caused by the stress or modify the response accordingly [12].…”

Section: Overview Of Cellular Stress and Cellular Responsementioning

confidence: 99%

Review-Influence of Nanomaterials on Cellular Stress, and Cellular Behavior

Lahir¹

2018

(ACT)

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The cellular responses to stress are a complex phenomenon. These have faced varied impacts of the advancements in biomolecular, cellular and biomedical fields that have taken place from time to time. Nanotechnology and nanomaterials have played their major roles in these advanced achievements. The interactions between cells and the various nanomaterials are obvious due to fabricated and/or engineered nanomaterials that are designed with special features to attain specific set targets. These nanomaterials are utilized in varied modes such as drug carriers, remedial agents of environmental aspects, biotechnological and biomedical processes, implants, biosensors etc. The implications of these wonder materials in any biosystems, industrial processes and products etc ensure their interactions with cells. Nanomaterials are also capable to induce cellular stress in biosystem as they are the components of the products used in daily life. There are numerous biomolecules and the cellular processes that are involved in intra and intercellular communications. The cellular communication is the prime functional aspect for cell survival. The interaction between the cells and the nanomaterials are likely to influence this cellular communications and other cellular processes. These features in all probabilities affect cellular responses. Cellular responses are protective and/ or rendering the affected cells prone to necrosis or cellular death. Various nanomaterials with different reactive affinities are bound to influence the cellular responses with respect to the stress. This reflects on the needs to evaluate and understand the mechanism involved during the process of cellular stress and the related behavior.

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Section: Overview Of Cellular Stress and Cellular Responsementioning

confidence: 99%

Review-Influence of Nanomaterials on Cellular Stress, and Cellular Behavior

Lahir¹

2018

(ACT)

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“…Integrins often mediate cell survival through activation of ERK1/2, Integrin-linked kinase (ILK) signaling [137], partially through NF-kB which in turn regulates secretion growth factors such as VEGF, FGF and BDNF [158]. Among other molecules variously participating in stem cell death regulation there are pro-apoptotic Rho/ROCK (Rho-associated kinase) [72, 159], mTORC1 and SIRT1 which are involved in stress adaptation and protection of cells, as has been demonstrated in animal models and in clinical trials [160], cytokines macrophage migration inhibitory factor (MIF) and GDF-15 [161]. Recent investigations have shown that MSCs produce a set of growth factors and promote cardioprotection via mechanisms involving AKT, PI3K, estrogen receptor-α and STAT3 pathways [53, 162–165].…”

Section: Transplantable Cell Death/survival Signalingmentioning

confidence: 99%

Stem cell death and survival in heart regeneration and repair

Abdelwahid¹,

et al. 2015

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Cardiovascular diseases are major causes of mortality and morbidity. Cardiomyocyte apoptosis disrupts cardiac function and leads to cardiac decompensation and terminal heart failure. Delineating the regulatory signaling pathways that orchestrate cell survival in the heart has significant therapeutic implications. Cardiac tissue has limited capacity to regenerate and repair. Stem cell therapy is a successful approach for repairing and regenerating ischemic cardiac tissue; however, transplanted cells display very high death percentage, a problem that affects success of tissue regeneration. Stem cells display multipotency or pluripotency and undergo self-renewal, however these events are negatively influenced by upregulation of cell death machinery that induces the significant decrease in survival and differentiation signals upon cardiovascular injury. While efforts to identify cell types and molecular pathways that promote cardiac tissue regeneration have been productive, studies that focus on blocking the extensive cell death after transplantation are limited. The control of cell death includes multiple networks rather than one crucial pathway, which underlies the challenge of identifying the interaction between various cellular and biochemical components. This review is aimed at exploiting the molecular mechanisms by which stem cells resist death signals to develop into mature and healthy cardiac cells. Specifically, we focus on a number of factors that control death and survival of stem cells upon transplantation and ultimately affect cardiac regeneration. We also discuss potential survival enhancing strategies and how they could be meaningful in the design of targeted therapies that improve cardiac function.

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New inter-correlated genes targeted by diatom-derived polyunsaturated aldehydes in the sea urchin Paracentrotus lividus

Ruocco

Fedele

Costantini

et al. 2017

Ecotoxicology and Environmental Safety

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The marine environment is continually subjected to the action of stressors (including natural toxins), which represent a constant danger for benthic communities. In the present work using network analysis we identified ten genes on the basis of associated functions (FOXA, FoxG, GFI-1, nodal, JNK, OneCut/Hnf6, TAK1, tcf4, TCF7, VEGF) in the sea urchin Paracentrotus lividus, having key roles in different processes, such as embryonic development and asymmetry, cell fate specification, cell differentiation and morphogenesis, and skeletogenesis. These genes are correlated with three HUB genes, Foxo, Jun and HIF1A. Real Time qPCR revealed that during sea urchin embryonic development the expression levels of these genes were modulated by three diatom-derived polyunsaturated aldehydes (PUAs), decadienal, heptadienal and octadienal. Our findings show how changes in gene expression levels may be used as an early indicator of stressful conditions in the marine environment. The identification of key genes and the molecular pathways in which they are involved represents a fundamental tool in understanding how marine organisms try to afford protection against toxicants, to avoid deleterious consequences and irreversible damages. The genes identified in this work as targets for PUAs can be considered as possible biomarkers to detect exposure to different environmental pollutants.

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Targeting Stress Responses for Regenerative Medicine

Cited by 3 publications

References 33 publications

Review-Influence of Nanomaterials on Cellular Stress, and Cellular Behavior

Review-Influence of Nanomaterials on Cellular Stress, and Cellular Behavior

Stem cell death and survival in heart regeneration and repair

New inter-correlated genes targeted by diatom-derived polyunsaturated aldehydes in the sea urchin Paracentrotus lividus

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