Targeting the blood–brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms, and their interplays

Wang, Yanping; Du, Weihong; Hu, Xianliang; Yu, Xin; Guo, Chun; Jin, Xinchun; Wang, Wei

doi:10.1016/j.apsb.2023.08.009

Cited by 14 publications

(5 citation statements)

References 254 publications

(321 reference statements)

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“…Furthermore, species such as Dorea and Eubacterium rectale perform distinct functions, activating immunological responses and generating beneficial SCFAs, respectively. These findings highlight the complex relationship between the gut microbiota and host physiology, with implications for both health and illness [2][3][4][5][6][7][8][9][10].…”

Section: The Gut Microbiota In Potential Treatment Strategiesmentioning

confidence: 85%

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The Role of the Gut Microbiota in Neurodegenerative Diseases

Philip Mani,

Balasubramanian,

Mali

et al. 2024

Microbiology Research

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The human gut has a rich and dynamic microbial population that plays an important role in many physiological activities. This review explores the complex interaction between the gut microbiota and human health, with an emphasis on its effect on neurodegenerative illnesses. The makeup of the gut microbiome and its impact on brain function through the gut–brain axis is highlighted. Dysbiosis, characterized by changes in the gut microbiota’s composition, has been linked to the development of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis. A Bidirectional communication between the stomach and the brain takes place via a variety of channels, including neurotransmitters and metabolites generated by gut bacteria. We investigate the processes through which dysbiosis causes neuroinflammation, oxidative stress, and neuronal damage, which drive disease development. Potential therapeutic approaches that focus on the gut microbiota, such as antibiotics, probiotics, prebiotics, and fecal microbiota transplantation, are reviewed, with promising preclinical and clinical findings. Overall, this study emphasizes the relevance of gut microbiota to neurodegenerative illnesses, as well as the need to understand and target the gut-brain axis for future treatment options.

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Section: The Gut Microbiota In Potential Treatment Strategiesmentioning

confidence: 85%

“…The blood-brain barrier (BBB) is crucial in regulating the flow of nutrients, as well as chemicals, between the blood and the brain. The GF mice exhibited higher blood-brain barrier permeability in comparison to SPF mice [5].…”

Section: Introductionmentioning

confidence: 83%

The Role of the Gut Microbiota in Neurodegenerative Diseases

Philip Mani,

Balasubramanian,

Mali

et al. 2024

Microbiology Research

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“…Probiotics may prevent immune actions like inflammatory responses by inhibiting TLR activation ( Dobielska et al, 2022 ). The reduced inflammatory state could enhance the blood-brain barrier integrity and improve neurological functions ( Wang et al, 2023 ). In addition to probiotic’s antioxidant and anti-inflammatory properties, they may improve cognitive function in depression by reducing hypothalamic-pituitary-adrenal (HPA)-axis dysfunction, and by increasing monoamine levels and neuroplasticity ( Dobielska et al, 2022 ).…”

Section: Mechanisms Underlying Probiotic Effects On the Gut-brain Axismentioning

confidence: 99%

Probiotics as modulators of gut-brain axis for cognitive development

Kumar,

Sivamaruthi,

Dey

et al. 2024

Front. Pharmacol.

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Various microbial communities reside in the gastrointestinal tract of humans and play an important role in immunity, digestion, drug metabolism, intestinal integrity, and protection from pathogens. Recent studies have revealed that the gut microbiota (GM) is involved in communication with the brain, through a bidirectional communication network known as the gut-brain axis. This communication involves humoral, immunological, endocrine, and neural pathways. Gut dysbiosis negatively impacts these communication pathways, leading to neurological complications and cognitive deficits. Both pre-clinical and clinical studies have demonstrated that probiotics can restore healthy GM, reduce intestinal pH, and reduce inflammation and pathogenic microbes in the gut. Additionally, probiotics improve cell-to-cell signaling and increase blood-brain-derived neurotrophic factors. Probiotics emerge as a potential approach for preventing and managing neurological complications and cognitive deficits. Despite these promising findings, the safety concerns and possible risks of probiotic usage must be closely monitored and addressed. This review article provides a brief overview of the role and significance of probiotics in cognitive health.

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“…Moreover, ageing also affects microbiota, particularly gut microbiota, and is associated with microbiome disturbance, named dysbiosis, which is characterized by a shift in microbiota populations and the loss of diversity [8,190]. Indeed, ageing-induced dysbiosis has been associated with the development of several diseases such as lung diseases [191], cardiovascular diseases [192], glaucoma [193] and neurological disorders [194].…”

Section: Dysbiosismentioning

confidence: 99%

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

Zuzarte,

Sousa,

Alves-Silva

et al. 2024

Biomedicines

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Ageing is a natural process characterized by a time-dependent decline of physiological integrity that compromises functionality and inevitably leads to death. This decline is also quite relevant in major human pathologies, being a primary risk factor in neurodegenerative diseases, metabolic disorders, cardiovascular diseases and musculoskeletal disorders. Bearing this in mind, it is not surprising that research aiming at improving human health during this process has burst in the last decades. Importantly, major hallmarks of the ageing process and phenotype have been identified, this knowledge being quite relevant for future studies towards the identification of putative pharmaceutical targets, enabling the development of preventive/therapeutic strategies to improve health and longevity. In this context, aromatic plants have emerged as a source of potential bioactive volatile molecules, mainly monoterpenes, with many studies referring to their anti-ageing potential. Nevertheless, an integrated review on the current knowledge is lacking, with several research approaches studying isolated ageing hallmarks or referring to an overall anti-ageing effect, without depicting possible mechanisms of action. Herein, we aim to provide an updated systematization of the bioactive potential of volatile monoterpenes on recently proposed ageing hallmarks, and highlight the main mechanisms of action already identified, as well as possible chemical entity–activity relations. By gathering and categorizing the available scattered information, we also aim to identify important research gaps that could help pave the way for future research in the field.

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Targeting the blood–brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms, and their interplays

Cited by 14 publications

References 254 publications

The Role of the Gut Microbiota in Neurodegenerative Diseases

The Role of the Gut Microbiota in Neurodegenerative Diseases

Probiotics as modulators of gut-brain axis for cognitive development

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

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