Targeting the cutaneous microbiota in atopic dermatitis: ‘A new hope’ or ‘attack of the CoNS’?

Chu, Chia-Yu

doi:10.1002/ctm2.865

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…The above findings indicate the complexity of the interactions between commensal CoNS and deleterious S. aureus and suggest that using Staphylococcus epidermidis as the treatment for dysbiosis in AD may further damage the skin and cause inflammation. Thus, a small molecule with a narrow‐spectrum effect, especially on Staphylococcus aureus , might be an attractive alternative for the treatment of AD [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Skin Commensal Bacteria Modulates the Immune Balance of Mice to Alleviate Atopic Dermatitis-Induced Damage

Yu¹,

Chen

Huang³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective Although studies indicate that Staphylococcus epidermidis ( S. epidermidis ) can regulate inflammation and anti-inflammatory cytokines, there is limited evidence supporting their effects on atopic dermatitis (AD). Here, we aimed to investigate the effects and potential mechanism of skin commensal bacteria on the immunity of mice with AD. Methods Twenty-four female BALB/C mice were selected and divided randomly into 4 groups: normal group, atopic dermatitis model group (AD), atopic dermatitis/substrate group (AD/substrates), and atopic dermatitis/substrates/epidermidis group (AD/ S. epidermidis ). All the mice were given different ways. After 14 days, their skin conditions were scored, and the serum, ear tissue, and inguinal lymph node tissue were collected and analyzed. Furthermore, the flow cytometry was used to analyze the number of CD4°+°CD25°+°Foxp3°+°Treg in the mouse lymph node tissue. Results Compared with the AD/substrate group, the mice ear thickness and dermatitis score were significantly reduced in the AD/ S. epidermidis group; skin epidermis, acanthosis, the degree of keratinization, inflammatory cell infiltration in the dermis, and the number of mast cells were declined. The serum levels of IgE, IgG1, IgG2a, and TNF- α , IFN- γ , IL-4, and Eotaxin were significantly declined in the AD/ S. epidermidis compared with the AD/substrate group. The proportion of CD4°+°CD25°+°Foxp3°+°Treg cells in the lymph node tissue was significantly increased in the AD/ S. epidermidis group compared with the AD/substrate group. Conclusion Staphylococcus epidermidis can regulate mice's immune balance to alleviate AD-induced skin damage.

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Section: Discussionmentioning

confidence: 99%

“…us, a small molecule with a narrow-spectrum e ect, especially on Staphylococcus aureus, might be an attractive alternative for the treatment of AD [30]. Mast cells are hematopoietic cells originating from bone marrow progenitor cells [31].…”

Section: Discussionmentioning

confidence: 99%

Skin Commensal Bacteria Modulates the Immune Balance of Mice to Alleviate Atopic Dermatitis-Induced Damage

Yu¹,

Chen

Huang³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Recently, ATx201 (Niclosamide), a small molecule, was introduced as a promising AD therapy ( 118 ). The therapeutic potential was attributed to ATx201’s narrow spectrum activity against S. aureus without causing damage to the commensal microbiome ( 119 ). Interestingly, inhibition of S. aureus growth by live bacteriotherapy in AD has also shown promising results ( 120 , 121 ).…”

Section: Perspectives and Challengesmentioning

confidence: 99%

Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis

et al. 2023

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Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly affects the patient’s quality of life. A disrupted skin barrier, type 2 cytokine-dominated inflammation, and microbial dysbiosis with increased Staphylococcus aureus colonization are critical components of AD pathogenesis. Patients with AD exhibit decreased expression of antimicrobial peptides (AMPs) which is linked to increased colonization by Staphylococcus aureus. The skin microbiome itself is a source of several AMPs. These host- and microbiome-derived AMPs define the microbial landscape of the skin based on their differential antimicrobial activity against a range of skin microbes or their quorum sensing inhibitory properties. These are particularly important in preventing and limiting dysbiotic colonization with Staphylococcus aureus. In addition, AMPs are critical for immune homeostasis. In this article, we share our perspectives about the implications of microbial derived AMPs in AD patients and their potential effects on overlapping factors involved in AD. We argue and discuss the potential of bacterial AMPs as therapeutics in AD.

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