Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management

Janković, Aleksandra; Korać, Aleksandra; Buzadžić, Biljana; Stančić, Ana; Otašević, Vesna; Ferdinándy, Péter; Daiber, Andreas; Korać, Bato

doi:10.1111/bph.13498

Cited by 49 publications

(75 citation statements)

References 254 publications

(289 reference statements)

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“…activity of soluble guanylyl cyclase [sGC]) (Stasch et al , ). It is also now recognized that perivascular adipose tissue (PVAT) contributes to vascular homeostasis by producing vasoactive compounds such as adipokines, reactive oxygen species (ROS) and • NO (Brown et al , ; Jankovic et al , ). It is beyond the scope of this review to address all of these tissues and processes involved in detail and we will mainly focus our discussion on pathways related to endothelial function in health and disease.…”

Section: Physiological Role Of Endothelial (Vascular) Functionmentioning

confidence: 99%

Targeting vascular (endothelial) dysfunction

Daiber

Steven

Weber

et al. 2016

British J Pharmacology

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Section: Physiological Role Of Endothelial (Vascular) Functionmentioning

confidence: 99%

Targeting vascular (endothelial) dysfunction

Daiber

Steven

Weber

et al. 2016

British J Pharmacology

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415

374

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“…Nowadays, it is widely accepted that radical‐triggered oxidation is one of the major regulatory mechanisms involved in a range of biological processes including redox signalling, proliferation, differentiation, apoptosis, inflammation, obesity and immune responses (Sarsour et al ., ; Negre‐Salvayre et al ., ; Forman et al ., ; Daiber et al ., ; Jankovic et al ., ). Formation of ROS is a necessary outcome of aerobic life and its complex antioxidative defence system.…”

Section: Recognition Of the Dualistic Role Of Ros And Rns Sets New Chmentioning

confidence: 99%

Biomarkers of oxidative and nitro‐oxidative stress: conventional and novel approaches

Gašparović

Žarković

et al. 2017

British J Pharmacology

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The concept of oxidative stress (OS) that connects altered redox biology with various diseases was introduced 30 years ago and has generated intensive research over the past two decades. Whereas it is now commonly accepted that macromolecule oxidation in response to ROS is associated with a variety of pathologies, the emergence of NO as a key regulator of redox signalling has led to the discovery of the pathophysiological significance of reactive nitrogen species (RNS). RNS can elicit various modifications of macromolecules and lead to nitrative or nitro-OS. In order to investigate oxidative and nitro-OS in human and in live animal models, circulating biomarker assays have been developed. This article provides an overview of key biomarkers used to assess lipid peroxidation and NO/NO 2 signalling, thereby stressing the necessity to analyse several OS biomarkers in relation to the overall (aerobic) metabolism and health condition of patients. In addition, the potential interest of heart rate variability as the non-invasive integrative biomarker of OS is discussed. LINKED ARTICLESThis article is part of a themed section on Redox Biology and Oxidative Stress in Health and Disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.12/issuetoc Abbreviations 4-HNE, trans-4-hydroxy-2-nonenal; ACR, acrolein; ALE, advanced lipoxidation end-products; DNP, 2,4-dinitrophenylhydrazine; FRR, free radical reaction; HRV, heart rate variability; LO, lipid alkoxyl radical; LOO, lipid peroxyl radical; LOOH, lipid hydroperoxide; LPO, lipid peroxidation; MDA, malondialdehyde; NO + , nitrosonium ion; Nrf2, Nuclear factor (erythroid-derived 2)-like 2; OMP, oxidatively modified protein; OS, oxidative stress; PUFA, polyunsaturated fatty acids; RNS, reactive nitrogen species; TBARS, thiobarbituric acid reactive substances; UPR, unfolded protein response IntroductionOxidative stress (OS), which was first introduced as a concept in redox biology and medicine in 1985 by Helmut Sies and Enrique Cadenas (Cadenas and Sies, 1985;Sies and Cadenas, 1985), has gained increasing interest over the years to become a major field of investigation in chemistry, life sciences and medicine.This concept connects oxidative chemistry with biological stress responses. However, it has the disadvantage of concealing redox chemistry, which plays a key role in cell homeostasis and signalling and in physiology, which is, for a large part, dependent on both oxidation and reduction reactions (Frein et al., 2005). This complex field of biochemistry, which plays a key role in the regulation of a variety of enzymes involved in essential signalling pathways, is now referred to as 'redox signalling' (Ullrich and Kissner, 2006) (Figure 1 et al., 2015). This reaction gives rise to peroxynitrite (ONOO À ), which is a highly reactive nitrogen species (RNS), producing nitration and nitrosation of substrates, often proteins that play important pathophysiological roles (Ullrich and Kissner, 2006;Schulz et al., 2008;Bottari, 20...

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“…S‐nitrosylation and S‐glutathionylation are reversible processes, the equilibrium of which can be shifted by activities of reductases, that is, thioredoxin and S‐nitrosoglutathione reductase . Tyrosine nitration, which is mainly mediated by ONOO − , is mostly irreversible modification that are generally responsible for cytotoxic effects of ˙NO because it potentially causes alteration, loss, or gain of important protein functions …”

Section: Reactive Nitrogen Speciesmentioning

confidence: 99%

Reactive oxygen, nitrogen, and sulfur species in human male fertility. A crossroad of cellular signaling and pathology

et al. 2019

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Infertility is a significant global health problem that currently affects one of six couples in reproductive age. The quality of male reproductive cells dramatically decreased over the last years and almost every aspect of modern life additionally worsen sperm functional parameters that consequently markedly increase male infertility. This clearly points out the importance of finding a new approach to treat male infertility. Redox signaling mediated by reactive oxygen, nitrogen and sulfur species (ROS, RNS, and RSS respectively), has appeared important for sperm reproductive function. Present review summarizes the current knowledge of ROS, RNS, and RSS in male reproductive biology and identifies potential targets for development of novel pharmacological and therapeutic approaches for male infertility by targeted therapeutic modulation of redox signaling.

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Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management

Abstract: This article is part of a themed section on Redox Biology and Oxidative Stress in Health and Disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.12/issuetoc.

Cited by 49 publications

References 254 publications

Targeting vascular (endothelial) dysfunction

Targeting vascular (endothelial) dysfunction

Biomarkers of oxidative and nitro‐oxidative stress: conventional and novel approaches

Reactive oxygen, nitrogen, and sulfur species in human male fertility. A crossroad of cellular signaling and pathology

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