2009
DOI: 10.1517/14728220903025762
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Targeting the Nrf2 pathway against cardiovascular disease

Abstract: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that controls the basal and inducible expression of a battery of antioxidant genes and other cytoprotective Phase II detoxifying enzymes. Nrf2 is ubiquitously expressed in the cardiovascular system. While several Nrf2 downstream genes have been implicated in protection against the pathogenesis of cardiovascular diseases, the precise role of Nrf2 in the cardiovascular system remains to be elucidated. Nevertheless, mounting evidence has revealed… Show more

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Cited by 161 publications
(128 citation statements)
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“…Nuclear factor erythroid-2 related factor 2 (Nrf2) is a member of the Cap 'n' Collar (CNC) family of basic leucine zipper (bZip) transcription factor (24)(25)(26)(27). There are also two additional Nrf proteins: Nrf1 and Nrf3.…”
Section: Nrf2 In the Upsmentioning
confidence: 99%
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“…Nuclear factor erythroid-2 related factor 2 (Nrf2) is a member of the Cap 'n' Collar (CNC) family of basic leucine zipper (bZip) transcription factor (24)(25)(26)(27). There are also two additional Nrf proteins: Nrf1 and Nrf3.…”
Section: Nrf2 In the Upsmentioning
confidence: 99%
“…Nrf2 forms a heterodimer with its obligator partner Maf, thereby binding to a cis-acting enhancer sequence known as the antioxidant response element (ARE) with a core nucleotide sequence of 5-RTGACNNNGC-3 to control the basal and inducible expression of more than 200 genes that can be grouped into several categories including antioxidant genes, phase II detoxifying enzymes, transcriptional factors, transporters, scavenger receptors, and chaperone proteins (24)(25)(26)(27). Thus the functions of Nrf2 spread rather broadly from antioxidant defense to cell cycle regulation and PQC.…”
Section: Nrf2 In the Upsmentioning
confidence: 99%
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