2021
DOI: 10.26434/chemrxiv-2021-k2mp6
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Targeting transthyretin in Alzheimer’s disease: drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer’s disease

Abstract: Transthyretin (TTR) has a well-established role in neuroprotection, evidenced in Alzheimer’s Disease (AD). By targeting TTR we have setup a drug discovery program of small-molecule compounds that act as chaperones, enhancing TTR/ amyloid-β peptide (Aβ) interactions. In a first stage, we carried out two computational drug repurposing approaches. In a second stage, the computationally selected compounds were assessed for their ability to bind and stabilize the TTR tetramer, using thyroxine displacement tests, an… Show more

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