Tart cherry (Prunus cerasus L.) dietary supplement modulates visceral adipose tissue CB1 mRNA levels along with other adipogenesis-related genes in rat models of diet-induced obesity

Cocci, Paolo; Moruzzi, Michele; Martinelli, Ilenia; Maggi, Federica; Bonaventura, Maria Vittoria Micioni Di; Cifani, Carlo; Mosconi, Gilberto; Tayebati, Seyed Khosrow; Damiano, Silvia; Lupidi, Giulio; Amantini, Consuelo; Tomassoni, Daniele; Palermo, Francesco Alessandro

doi:10.1007/s00394-020-02459-y

Cited by 18 publications

(31 citation statements)

References 72 publications

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“…After 5 weeks (12 weeks of age) of HFD, the obese phenotype was established, and DIO ( n = 8) and CHOW ( n = 8) rats were sacrificed. The remaining DIO rodents were fed with HFD for further 12 weeks (24 weeks of age), for a total of 17 weeks of HFD, while the remaining CHOW rats were fed with the standard diet [ 17 , 18 , 41 , 42 , 43 ]. In the groups of DIO animals, after 17 weeks of HFD, rats that were resistant to increase of body weight ( n = 3) were excluded from the experiment because they did not become obese [ 42 , 44 , 45 , 46 , 47 ].…”

Section: Methodsmentioning

confidence: 99%

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Obesity-Related Brain Cholinergic System Impairment in High-Fat-Diet-Fed Rats

et al. 2022

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A link between obesity and cerebral health is receiving growing recognition. Here, we investigate in the frontal cortex and hippocampus the potential involvement of cholinergic markers in brain alterations previously reported in rats with obesity induced by diet (DIO) after long-term exposure (17 weeks) to a high-fat diet (HFD) in comparison with animals fed with a standard diet (CHOW). The obesity developed after 5 weeks of HFD. Bodyweight, systolic blood pressure, glycemia, and insulin levels were increased in DIO rats compared to the CHOW group. Measurements of malondialdehyde (MDA) provided lipid peroxidation in HFD-fed rats. Western blot and immunohistochemical techniques were performed. Our results showed a higher expression of choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) in obese rats but not the VAChT expression in the frontal cortex after 17 weeks of HFD. Furthermore, the acetylcholinesterase (AChE) enzyme was downregulated in HFD both in the frontal cortex and hippocampus. In the brain regions analyzed, it was reported a modulation of certain cholinergic receptors expressed pre- and post-synaptically (alpha7 nicotinic receptor and muscarinic receptor subtype 1). Collectively, these findings point out precise changes of cholinergic markers that can be targeted to prevent cerebral injuries related to obesity.

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Section: Methodsmentioning

confidence: 99%

“…The thiobarbituric-acid-reactive substances (TBARS) quantity, measured as the malondialdehyde (MDA), was evaluated in the serum. The assay kits and all these procedures were reported previously [ 17 , 18 , 41 , 42 , 43 ]. Finally, the brains were removed and divided in two hemispheres.…”

Section: Methodsmentioning

confidence: 99%

Obesity-Related Brain Cholinergic System Impairment in High-Fat-Diet-Fed Rats

et al. 2022

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“…To avoid misinterpretation of the effect of the probiotic, rats that were resistant to increasing body weight [ 106 , 107 , 108 , 109 ] and thus developing the obese phenotype [ 110 , 111 , 112 ] were excluded from the experiment. As described above, the probiotic supplementation started on the first day of access to the CAF diet, and thus the phenotype was not yet clearly expressed.…”

Section: Methodsmentioning

confidence: 99%

Supplementation with Lactiplantibacillus plantarum IMC 510 Modifies Microbiota Composition and Prevents Body Weight Gain Induced by Cafeteria Diet in Rats

Bonaventura

Coman²,

Tomassoni

et al. 2021

IJMS

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Changes in functionality and composition of gut microbiota (GM) have been associated and may contribute to the development and maintenance of obesity and related diseases. The aim of our study was to investigate for the first time the impact of Lactiplantibacillus (L.) plantarum IMC 510 in a rat model of diet-induced obesity, specifically in the cafeteria (CAF) diet. This diet provides a strong motivation to voluntary overeat, due to the palatability and variety of selected energy-dense foods. The oral administration for 84 days of this probiotic strain, added to the CAF diet, decreased food intake and body weight gain. Accordingly, it ameliorated body mass index, liver and white adipose tissue weight, hepatic lipid accumulation, adipocyte size, serum parameters, including glycemia and low-density lipoprotein levels, in CAF fed rats, potentially through leptin control. In this scenario, L. plantarum IMC 510 showed also beneficial effects on GM, limiting the microbial imbalance established by long exposure to CAF diet and preserving the proportion of different bacterial taxa. Further research is necessary to better elucidate the relationship between GM and overweight and then the mechanism of action by which L. plantarum IMC 510 modifies weight. However, these promising results prompt a clear advantage of probiotic supplementation and identify a new potential probiotic as a novel and safe therapeutic approach in obesity prevention and management.

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“…Up-regulation of TRPV2 was also observed in obese and diabetic (db/db) mice ( Sun et al, 2016a , 2017a ). It has also been reported that tart cherry may attenuate adipogenesis by acting directly on the adipose tissue and down-regulating the HFD-induced mRNA expression of TRPV1 and TRPV2 ( Cocci et al, 2021 ). These findings suggested that TRPV2 might be contributed to adipocyte thermogenesis.…”

Section: Trpv2mentioning

confidence: 99%

Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

Sun

Luo

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Obesity prevalence became a severe global health problem and it is caused by an imbalance between energy intake and expenditure. Brown adipose tissue (BAT) is a major site of mammalian non-shivering thermogenesis or energy dissipation. Thus, modulation of BAT thermogenesis might be a promising application for body weight control and obesity prevention. TRP channels are non-selective calcium-permeable cation channels mainly located on the plasma membrane. As a research focus, TRP channels have been reported to be involved in the thermogenesis of adipose tissue, energy metabolism and body weight regulation. In this review, we will summarize and update the recent progress of the pathological/physiological involvement of TRP channels in adipocyte thermogenesis. Moreover, we will discuss the potential of TRP channels as future therapeutic targets for preventing and combating human obesity and related-metabolic disorders.

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Tart cherry (Prunus cerasus L.) dietary supplement modulates visceral adipose tissue CB1 mRNA levels along with other adipogenesis-related genes in rat models of diet-induced obesity

Cited by 18 publications

References 72 publications

Obesity-Related Brain Cholinergic System Impairment in High-Fat-Diet-Fed Rats

Obesity-Related Brain Cholinergic System Impairment in High-Fat-Diet-Fed Rats

Supplementation with Lactiplantibacillus plantarum IMC 510 Modifies Microbiota Composition and Prevents Body Weight Gain Induced by Cafeteria Diet in Rats

Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

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