TAT peptide-modified cisplatin-loaded iron oxide nanoparticles for reversing cisplatin-resistant nasopharyngeal carcinoma

Weng, Huanhuan; Bejjanki, Naveen Kumar; Zhang, Juan; Miao, Xiangwan; Zhong, Ying; Li, Hailiang; Xie, Huifen; Wang, Siqi; Li, Quanming; Xie, Mingxing

doi:10.1016/j.bbrc.2019.02.117

Cited by 28 publications

(14 citation statements)

References 27 publications

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“…Free thiols can interact with maleimide residues to form a stable carbon-sulfur bond, as demonstrated by various groups for the covalent attachment of CPPs, such as RF, LMWP, or Tat to liposomes, dendrimers, or protein-based NPs [60][61][62]. Alternatively, the high affinity of noble metals to sulfur, which derives from the soft acid-soft base interaction, can be employed for the direct linkage of sulfhydryl-containing CPPs to the surface of metal NPs, as recently demonstrated for R8 and Tat conjugation to silver, gold, and palladium NPs [63][64][65][66][67].…”

Section: Covalent Attachmentmentioning

confidence: 99%

Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy

Gessner

Neundorf

2020

IJMS

155

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Based on their tunable physicochemical properties and the possibility of producing cell-specific platforms through surface modification with functional biomolecules, nanoparticles (NPs) represent highly promising tools for biomedical applications. To improve their potential under physiological conditions and to enhance their cellular uptake, combinations with cell-penetrating peptides (CPPs) represent a valuable strategy. CPPs are often cationic peptide sequences that are able to translocate across biological membranes and to carry attached cargos inside cells and have thus been recognized as versatile tools for drug delivery. Nevertheless, the conjugation of CPP to NP surfaces is dependent on many properties from both individual components, and further insight into this complex interplay is needed to allow for the fabrication of highly stable but functional vectors. Since CPPs per se are nonselective and enter nearly all cells likewise, additional decoration of NPs with homing devices, such as tumor-homing peptides, enables the design of multifunctional platforms for the targeted delivery of chemotherapeutic drugs. In this review, we have updated the recent advances in the field of CPP-NPs, focusing on synthesis strategies, elucidating the influence of different physicochemical properties, as well as their application in cancer research.

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Section: Covalent Attachmentmentioning

confidence: 99%

Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy

Gessner

Neundorf

2020

IJMS

155

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“…There are reports of a reduced hyperthermia effect when nanoparticles are located in endosomes, and reports of spontaneous endosomal escape [ 113 – 114 ]. For the specific treatment of cisplatin-resistant nasopharyngeal carcinoma, Weng et al [ 115 ] produced SPIONs covered with cisplatin and with TAT peptide (a HIV-derived cell penetrating peptide). Their nanoparticles had an increased endocytosis rate, which, combined with the Fenton reaction of the iron oxide core taking place in the lysosome and the cell cytoplasm, increased the cancer cell response to cisplatin and reversed the resistance of the cells to the drug [ 115 ].…”

Section: Reviewmentioning

confidence: 99%

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

Suciu¹,

Ionescu²,

Ciorîță³

et al. 2020

Beilstein J. Nanotechnol.

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Superparamagnetic iron oxide nanoparticles (SPIONs) have unique properties with regard to biological and medical applications. SPIONs have been used in clinical settings although their safety of use remains unclear due to the great differences in their structure and in intra- and inter-patient absorption and response. This review addresses potential applications of SPIONs in vitro (formulations), ex vivo (in biological cells and tissues) and in vivo (preclinical animal models), as well as potential biomedical applications in the context of drug targeting, disease treatment and therapeutic efficacy, and safety studies.

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“…Furthermore, Liu et al [113] and Weng et al [114] exploited cell-penetrating peptides to deliver Ag-Fe3O4 with DOX and Fe3O4 loaded with Pt, respectively. The proposed NPs were characterized not only by an enhanced internalization but also showed unexpected ability -mediated by ROS produced via the Fenton reaction -to reverse drug-resistance in HNE-1/DDP and CNE-2 cells.…”

Section: Magnetic Nanocarriersmentioning

confidence: 99%

Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer

Benko¹

2020

CDR

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Cancer is one of the biggest healthcare concerns in our century, a disease whose treatment has become even more difficult following reports of drug-resistant tumors. When this happens, chemotherapy treatments fail or decrease in efficiency, leading to catastrophic consequences to the patient. This discovery, along with the fact that drug resistance limits the efficacy of current treatments, has led to a new wave of discovery for new methods of treatment. The use of nanomedicine has been widely studied in current years as a way to effectively fight drug resistance in cancer. Research in the area of cancer nanotechnology over the past decades has led to tremendous advancement in the synthesis of tailored nanoparticles with targeting ligands that can successfully attach to chemotherapy-resistant cancer by preferentially accumulating within the tumor region through means of active and passive targeting. Consequently, these approaches can reduce the off-target accumulation of their payload and lead to reduced cytotoxicity and better targeting. This review explores some categories of nanocarriers that have been used in the treatment of drug-resistant cancers, including polymeric, viral, lipid-based, metal-based, carbon-based, and magnetic nanocarriers, opening the door for an exciting field of discovery that holds tremendous promise in the treatment of these tumors.

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TAT peptide-modified cisplatin-loaded iron oxide nanoparticles for reversing cisplatin-resistant nasopharyngeal carcinoma

Cited by 28 publications

References 27 publications

Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy

Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer

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