Implementation of the Mayor's Policy instructions on the Prohibition of the Use of Plastic Bags in modern liters such as minimarket hypermart and shops and other entrepreneurs in Jayapura City. Prohibiting the use of plastic bags is beneficial for developed and developing regions such as Jayapura City, because with the increase in population has an impact on increasing community needs, it can result in increased volume of plastic waste, which will adversely affect the community environment. The problem of this research was how the implementation of the Jayapura Mayor's policy on the prohibition of the use of plastic bags and what factors influenced the implementation of the policy in pandemic situation. While the purpose of this study was to find out and analyzed the implementation of policies as well as the factors that influenced policy implementation. The method used in this study was a qualitative research method where primary and secondary data were analyzed using the theory of Marille S. Grindle, the research result was the implementation of the Jayapura Mayor's policy instructions on the prohibition of using plastic bags that had been carried out by modern literary owners and entrepreneurs as well as society by not providing plastic bags anymore. Because all respondents said that plastic bags are materials that are difficult to decompose and damage the environment, this instruction became one of the things that is important for the life of the community and made a large contribution to entrepreneurs. While this situation, pandemic covid-19 make any degradation of uses plastic. The factors that influence the implementation of policies are adaptation to policies, initially the market compren because they have ordered plastic bags in large quantities and the government provides tolerance to spend the plastic bags with the condition not to order them again, until finally until now modern liters in the city of jayapura have implemented the mayor of jayapura's instructions on the ban on the use of plastic bags optimally.