Taurine ameliorate alloxan induced oxidative stress and intrinsic apoptotic pathway in the hepatic tissue of diabetic rats

Rashid, Kahkashan; Das, Joydeep; Sil, Parames C.

doi:10.1016/j.fct.2012.10.007

Cited by 115 publications

(74 citation statements)

References 89 publications

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“…Taurine, a free amino acid, is known to counteract oxidative stress in tissues (liver, kidney and retina) [49,50] . As reported by Rashid et al, taurine may ameliorate oxidative stress in the complications of diabetic-induced liver injury [51] . Increased levels of taurine in CKD patients were reported as a cure for ameliorating oxidative stress [52] .…”

Section: Discussionmentioning

confidence: 68%

Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis

et al. 2014

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Aim: To test the hypothesis that the traditional Chinese medicine Cordyceps sinensis could improve the metabolic function of extrarenal organs to achieve its anti-chronic kidney disease (CKD) effects. Methods: Male SD rats were divided into CKD rats (with 5/6-nephrectomy), CKD rats treated with Cordyceps sinensis (4 mg·kg -1 ·d -1 , po), and sham-operated rats. After an 8-week treatment, metabolites were extracted from the hearts and livers of the rats, and then subjected to 1 H-NMR-based metabolomic analysis. Results: Oxidative stress, energy metabolism, amino acid and protein metabolism and choline metabolism were considered as links between CKD and extrarenal organ dysfunction. Within the experimental period of 8 weeks, the metabolic disorders in the liver were more pronounced than in the heart, suggesting that CKD-related extrarenal organ dysfunctions occurred sequentially rather than simultaneously. Oral administration of Cordyceps sinensis exerted statistically significant rescue effects on the liver and heart by reversely regulating levels of those metabolites that are typically perturbed in CKD. Conclusion: Oral administration of Cordyceps sinensis significantly attenuates the liver and heart injuries in CKD rats. The 1 H NMRbased metabolomic approach has provided a systematic view for understanding of CKD and the drug treatment, which can also be used to elucidate the mechanisms of action of other traditional Chinese medicines.

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Section: Discussionmentioning

confidence: 68%

Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis

et al. 2014

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“…These events lead to hyperglycemia, and persistent 45 hyperglycemia induces excessive production of reactive oxygen species 46 (ROS) in diabetic subject [5]. Evidence suggests that DM-mediated 47 oxidative stress and altered antioxidant defense of male reproductive 48 system results in infertility/subfertility in the diabetic patient [6-10]. 49 Mammalian sperm cells contain a high amount of polyunsaturated 50 fatty acid that undergoes oxidation to affect sperm motility and fertility 51 [11].…”

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confidence: 99%

Curcumin ameliorates testicular damage in diabetic rats by suppressing cellular stress-mediated mitochondria and endoplasmic reticulum-dependent apoptotic death

Rashid

Sil

2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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In the present study, we sought to explore whether curcumin plays any beneficial role against STZ induced testicular abnormalities in diabetic rats, and if so, what possible mechanism it utilizes to provide protection. Exposure to STZ (50mg/kg body weight, i.p., once) reduced testis-to-body weight ratio, enhanced blood glucose level and intracellular ROS, altered testicular markers, diminished serum testosterone and impaired cellular redox balance. Administration of curcumin at a dose of 100mg/kg body weight for 8 weeks effectively normalized all the alterations. Curcumin also showed inhibitory effect on the elevation of pro-inflammatory cytokines and translocation of NFκB into the nucleus and promoted the activation of the transcription factor Nrf-2 to provide protection against oxidants. To protect cells from STZ-induced stress-mediated damage, curcumin acted on the key mediators of the apoptotic cell death such as JNK and p38. In addition, this active molecule upregulated Bcl-2 expression, blocked the expression of pro-apoptotic proteins (Bax, Bad and Bid), decreased intracellular Ca(2+) level, inhibited active caspase cascade and attenuated PARP cleavage. These results suggest that curcumin provides protection against cellular stress-mediated mitochondrial and endoplasmic reticulum-dependent apoptotic death of the testicular cells under diabetic condition and suggests the possibility of using this molecule as a potential therapeutic in the treatment of stress-mediated diabetic testicular dysfunction.

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“…41 Increased blood glucose, decreased plasma insulin, decreased C peptide and associated changes in urine sugar, haemoglobin and glycosylated haemoglobin are all typical features of alloxan-induced diabetes. 42,43 All of these factors were normalised by oral administration of FSP to diabetic rats in the present investigation.…”

Section: Discussionmentioning

confidence: 99%

Effects of freeze-dried Fragaria x ananassa powder on alloxan-induced diabetic complications in Wistar rats

Abdulazeez

2014

Journal of Taibah University Medical Sciences

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Objectives: Strawberries contain antioxidant phytochemicals, which have been shown to beneficial against inflammation, cardiovascular disease, cancer, obesity, neurodegeneration, hyperglycaemia and associated diabetic complications. Freeze-dried strawberry powder (FSP) is effective in controlling metabolic syndrome and cardiovascular risk factors. The present investigation was designed to evaluate the effect of FSP on alloxan-induced diabetes in rats.Methods: Diabetes was induced in male Wistar albino rats by intraperitoneal injection of alloxan monohydrate (150 mg/kg bw), and treatment with FSP (700 mg/day for 45 days) was started 48 h after alloxan injection. Blood glucose, insulin, C-peptide, haemoglobin, renal function markers (urea, uric acid and creatinine) and enzyme markers (aspartate and alanine transaminases and alkaline phosphatase) were assayed with suitable methods.Results: Animals given alloxan had significant body weight loss, poor glucose tolerance and increased blood glucose with concomitant decreases in insulin, C-peptide and haemoglobin values, and significant (p < 0.05) changes in the levels of renal function markers and enzyme activities. Oral administration of FSP for 45 days significantly (p < 0.05) reverted the body weight loss, hyperglycaemia, biochemical parameters, enzyme activities and insulin levels to near normal levels.Conclusions: FSP can revert alloxan-induced diabetes and its complications. The antioxidant properties of the fruit probably play a major role in the observed changes.

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Taurine ameliorate alloxan induced oxidative stress and intrinsic apoptotic pathway in the hepatic tissue of diabetic rats

Cited by 115 publications

References 89 publications

Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis

Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis

Curcumin ameliorates testicular damage in diabetic rats by suppressing cellular stress-mediated mitochondria and endoplasmic reticulum-dependent apoptotic death

Effects of freeze-dried Fragaria x ananassa powder on alloxan-induced diabetic complications in Wistar rats

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