Taurine chloramine inhibits PMA-stimulated superoxide production in human neutrophils perhaps by inhibiting phosphorylation and translocation of p47phox

Taurine chloramine inhibits functional responses of human eosinophils in vitro

“…Eosinophils display a higher superoxide production upon stimulation as compared with neutrophils [38], and the components of the NADPH oxidase are expressed more abundantly in eosinophils than in neutrophils [4]. TauCl has been recently shown to inhibit phorbol‐stimulated superoxide production in human neutrophils by inhibiting the phosphorylation and translocation of p47 phox [39]. In the present study we show that TauCl elicited a marked inhibition of p47 phox translocation in human eosinophils while taurine was without effect.…”

Taurine chloramine induces heme oxygenase-1 expression via Nrf2 activation in murine macrophages

“…TauCl inhibited the overproduction of O 2 − and NO in the PMA or LPSstimulated phagocytes [26,36]. Thus, induction of HO-1 expression afforded protection of activated phagocytes against cytotoxicity caused by O 2 − , NO and highly reactive ONOO − [37].…”

Taurine Chloramine Activates Nrf2, Increases HO-1 Expression and Protects Cells from Death Caused by Hydrogen Peroxide

“…To distinguish the proportion of cells undergoing necrotic and apoptotic deaths, propidium iodide (PI) and annexin V staining assays were employed [9, 21]. Cells stained with PI and annexin V, were analyzed on FACScan cytometer (BD Bioscience, San Jose, CA) using CellQuest software (BD Bioscience).…”