Taurine enhances spermatogenic function and antioxidant defense mechanisms in testes and epididymis of L-NAME-induced hypertensive rats

Adedara, Isaac A.; Alake, Sanmi; Adeyemo, Mercy O.; Olajide, Laide Omoyiola; Ajibade, Temitayo Olabisi; Farombi, Ebenezer O.

doi:10.1016/j.biopha.2017.10.095

Cited by 40 publications

(25 citation statements)

References 49 publications

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“…Rats that received L-NAME presented high blood pressure, testicular dysfunction and morphological changes. In L-NAMEtreated rats, the BW, as well as the weight of testes and epididymides, did not differ from those in normal rats, as reported in a previous study (Adedara et al, 2018). It is well accepted that chronic treatment with L-NAME produces systemic vasoconstriction and high blood pressure because of decreased NO bioavailability (Potue et al, 2019).…”

Section: Discussionsupporting

confidence: 75%

“…Long-term treatment with L-NAME, a NOS inhibitor, is widely employed to induce high blood pressure in experimental animals via the reduction of NO production (Saravanakumar & Raja, 2011). Several studies have reported that NO-deficient rats exhibit poor sperm quality, accompanied by increased ROS generation and decreased NO concentration in reproductive organs (Adedara et al, 2018;Akinyemi et al, 2015 (Nakmareong et al, 2011;Trakoontivakorn et al, 2001). Kukongviriyapan et al have shown that the CF extract reduces systemic oxidative stress markers and restores vascular responses to acetylcholine in a rat model of oxidative stress (Kukongviriyapan et al, 2007;Sripanidkulchai et al, 2010).…”

Section: •-mentioning

confidence: 99%

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Cratoxylum formosum dyer extract alleviates testicular damage in hypertensive rats

et al. 2020

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Hypertension is a chronic disorder that contributes to cardiovascular disease (World Health, 2009). Currently, it is the major cause of morbidity and mortality in people worldwide (James et al., 2014). Hypertension associated with sexual dysfunction has been reported in male patients with hypertension (Fogari et al., 2001). Additionally, decreased sexual activity has been observed in male patients with essential hypertension, which has been associated with reduced testosterone levels (Fogari et al., 2002). A previous study has reported that serum total testosterone and epididymal sperm motility are significantly reduced in rats with nitric oxide (NO) depletion (Adedara et al., 2018). It is well known that testosterone is an essential hormone for the initiation and maintenance of spermatogenic processes (Chauhan et al., 2007), synthesised by testicular Leydig cells using cholesterol as its substrate (Li et al., 2011). The biosynthesis of testosterone requires steroidogenic acute regulatory protein (StAR), a mitochondrial cholesterol transporter, that transfers lipids from outside the mitochondrial membrane to the inside (Stocco, 2001). Reportedly,

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Section: Discussionsupporting

confidence: 75%

Section: •-mentioning

confidence: 99%

Cratoxylum formosum dyer extract alleviates testicular damage in hypertensive rats

et al. 2020

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“…The protein content of the experimental samples was measured by the method of Bradford using crystalline serum bovine albumin (BSA) as a standard [49]. To 15 μL of the homogenate or BSA (1 mg/mL), 750 μL of the Bradford reagent was added.…”

Section: Methodsmentioning

confidence: 99%

Antioxidant and nephroprotection activities of Combretum micranthum: A phytochemical, in-vitro and ex-vivo studies

Kpemissi

Eklu-Gadégbéku

Veerapur

et al. 2019

Heliyon

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Management of chronic renal failure is exceedingly expensive. Despite of encouraging experimental outcomes, there is a lack of potent nephroprotective drugable molecules in a clinics or market. To develop a nephroprotective phytomedicine, the present study was designed to do a literature survey on reported phytochemical and biological analysis of Combretum micranthum and to carry out chemoprofiling, in-vitro antioxidant and ex-vivo nephroprotective capacity of the title plant. The phytochemical and biological activity survey of C. micranthum has reveals the presence of many bioactive compounds such as flavonoids, terpenoids, steroids and alkaloids with many biological activities. Phytochemical investigation re-confirmed the presence of these compounds. Hydroalcoholic extract of C. micranthum (CM extract) showed a strong antioxidant activity by scavenging AAPH, DPPH, nitric oxide, hydrogen peroxide and chelating metal ions. CM extract exhibited significant ( P < 0.001) dose dependent inhibition of ferric chloride-ascorbic acid induced lipid peroxidation. Diabetic nephropathy is a serious and common complication leading to end stage renal disease. Therefore, in the present study, glucose-induced toxicity was also studied in human embryonic kidney cells (HEK-293) as an in vitro model for diabetic nephropathy. The results showed that exposure of cells to high glucose (100 mM) for 72 h significantly reduced the cell viability resulting in morphological changes such as cell shrinkage, rounded cell shape and cytoplasmic vacuolation. Treatment with CM extract at 10 and 25 μg/mL resulted in significant improvement in cell viability from 10 to 23% compared to the high glucose control. This study demonstrated the potential antioxidant and nephroprotective properties of C. micranthum , justifying its traditional use in the treatment of various diseases.

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“…However, a previous 28‐day study showed a reduction of the SOD and catalase activities due to the administration of L‐NAME. Also, the above‐mentioned study found that the reduction of the activity was slowed down when taurine or an antihypertensive drug was supplied to hypertension‐induced rats (Adedara et al., 2018). According to Table 3, when captopril was given to rats, a non‐significant increase in both enzymes is reported as well as when L‐NAME alone was supplied.…”

Section: Resultsmentioning

confidence: 99%

Impact of consumption of cooked red and blackChenopodium quinoaWilld. over blood lipids, oxidative stress, and blood glucose levels in hypertension‐induced rats

et al. 2020

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Background and objectives Hypertension is associated with the overproduction of free radicals, generating oxidative stress, which could contribute to the lipid peroxidation, altering the blood lipid levels, and to the development of diseases such as diabetes. The aim of this work was to evaluate the bioactivity of cooked red and black quinoa over blood lipids, oxidative stress, and glucose levels in hypertension‐induced rats by the supply of the drug N (ω)‐nitro‐L‐arginine methyl ester (L‐NAME). Findings The consumption of red quinoa increased significantly (p < .05) the levels of high‐density lipoprotein (HDL). In addition, the quinoa consumption, regardless of the variety, not only increased the activity of antioxidant enzymes (superoxide dismutase and catalase), but also reduced blood glucose levels. The total phenolic compounds and total flavonoid content were higher in red than in black quinoa, while this latter obtained better values for the total antioxidant activity. Conclusions The presence of bioactive compounds in quinoa could be responsible for its capacity to improve the HDL levels, the in vivo antioxidant activity, and the levels of fasting blood glucose in hypertension‐induced rats. Significance and novelty Findings from this study could promote the consumption of quinoa, which seems to be a good source in the development of functional foods, in order to take advantages of its bioactivities.

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Taurine enhances spermatogenic function and antioxidant defense mechanisms in testes and epididymis of L-NAME-induced hypertensive rats

Cited by 40 publications

References 49 publications

Cratoxylum formosum dyer extract alleviates testicular damage in hypertensive rats

Cratoxylum formosum dyer extract alleviates testicular damage in hypertensive rats

Antioxidant and nephroprotection activities of Combretum micranthum: A phytochemical, in-vitro and ex-vivo studies

Impact of consumption of cooked red and blackChenopodium quinoaWilld. over blood lipids, oxidative stress, and blood glucose levels in hypertension‐induced rats

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