Taurine Prevents Hypertension and Increases Exercise Capacity in Rats With Fructose-Induced Hypertension

Rahman, Mizanur; Park, Hyemin; Kim, Shang-Jin; Go, Hyeon-Kyu; Kim, Gi-Beum; Hong, Chul−Un; Lee, Young-Up; Kim, Sung-Zoo; Kim, Jin-Shang; Kang, Hyung-Sub

doi:10.1038/ajh.2011.4

Cited by 26 publications

(15 citation statements)

References 35 publications

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“…One of the most studied interventions is that of the amino acid taurine with a number of studies reporting beneficial effects of taurine supplementation in the setting of fructose-induced metabolic disorders [84–87]. Taurine has been shown to prevent hypertension and increase exercise capacity in rats with fructose-induced hypertension, possibly via antioxidation and maintenance of nitric oxide concentrations [88, 89]. Using a model of 25% fructose intake, it has been shown that taurine and L-arginine have synergistic effects on attenuating insulin resistance hypertension [90].…”

Section: Countering the Adverse Metabolic Effects Of Fructosementioning

confidence: 99%

Early Life Exposure to Fructose and Offspring Phenotype: Implications for Long Term Metabolic Homeostasis

Sloboda

Patel

et al. 2014

Journal of Obesity

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The consumption of artificially sweetened processed foods, particularly high in fructose or high fructose corn syrup, has increased significantly in the past few decades. As such, interest into the long term outcomes of consuming high levels of fructose has increased significantly, particularly when the exposure is early in life. Epidemiological and experimental evidence has linked fructose consumption to the metabolic syndrome and associated comorbidities—implicating fructose as a potential factor in the obesity epidemic. Yet, despite the widespread consumption of fructose-containing foods and beverages and the rising incidence of maternal obesity, little attention has been paid to the possible adverse effects of maternal fructose consumption on the developing fetus and long term effects on offspring. In this paper we review studies investigating the effects of fructose intake on metabolic outcomes in both mother and offspring using human and experimental studies.

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Section: Countering the Adverse Metabolic Effects Of Fructosementioning

confidence: 99%

Early Life Exposure to Fructose and Offspring Phenotype: Implications for Long Term Metabolic Homeostasis

Sloboda

Patel

et al. 2014

Journal of Obesity

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“…Furthermore, Rahman et al (40) showed that skeletal muscle NO is significantly reduced in rats that consumed food containing 43.6% fructose for 4 wk and that swimming exercise failed to normalize NO levels. It is therefore possible that the observed attenuation of the epigenetic modifications by exercise in fructose-fed rats might have arisen from the effects of fructose on eNOS.…”

Section: E281mentioning

confidence: 99%

Suppression of the GLUT4 adaptive response to exercise in fructose-fed rats

Goyaram

Kohn

Ojuka

2014

American Journal of Physiology-Endocrinology and Metabolism

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Goyaram V, Kohn TA, Ojuka EO. Suppression of the GLUT4 adaptive response to exercise in fructose-fed rats. Am J Physiol Endocrinol Metab 306: E275-E283, 2014. First published December 19, 2013 doi:10.1152/ajpendo.00342.2013.-Exercise-induced increase in skeletal muscle GLUT4 expression is associated with hyperacetylation of histone H3 within a 350-bp DNA region surrounding the myocyte enhancer factor 2 (MEF2) element on the Glut4 promoter and increased binding of MEF2A. Previous studies have hypothesized that the increase in MEF2A binding is a result of improved accessibility of this DNA segment. Here, we investigated the impact of fructose consumption on exercise-induced GLUT4 adaptive response and directly measured the accessibility of the above segment to nucleases. Male Wistar rats (n ϭ 30) were fed standard chow or chow ϩ 10% fructose or maltodextrin drinks ad libitum for 13 days. In the last 6 days five animals per group performed 3 ϫ 17-min bouts of intermittent swimming daily and five remained untrained. Triceps muscles were harvested and used to measure 1) GLUT4, pAMPK, and HDAC5 contents by Western blot, 2) accessibility of the DNA segment from intact nuclei using nuclease accessibility assays, 3) acetylation level of histone H3 and bound MEF2A by ChIP assays, and 4) glycogen content. Swim training increased GLUT4 content by ϳ66% (P Ͻ 0.05) but fructose and maltodextrin feeding suppressed the adaptation. Accessibility of the DNA region to MNase and DNase I was significantly increased by swimming (ϳ2.75-and 5.75-fold, respectively) but was also suppressed in trained rats that consumed fructose or maltodextrin. Histone H3 acetylation and MEF2A binding paralleled the accessibility pattern. These findings indicate that both fructose and maltodextrin modulate the GLUT4 adaptive response to exercise by mechanisms involving chromatin remodeling at the Glut4 promoter.

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“…16 Recent animal and human studies have shown that taurine supplementation lowers BP and improves vascular function, possibly through suppression of renin-angiotensin-aldosterone system activity, 17,18 augmentation of kallikrein activity in the blood and peripheral tissues, 19 suppression of the renal sympathetic nervous system, 9,20 diuretic and natriuretic activities, and vasorelaxant activity. 21 H 2 S can regulate vascular tone through several mechanisms, such as acting on ATP-sensitive potassium channels. [22][23][24] A recent study has found that H 2 S also affects transient receptor potential channels (TRPCs) in mesenchymal stem cells and regulates calcium homeostasis.…”

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confidence: 99%

Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension

et al. 2016

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P rehypertension is highly prevalent worldwide.1 It is estimated that ≈30% to 50% of the population have this condition. It frequently complicates other cardiometabolic risk factors and is closely associated with coronary heart disease, stroke, and renal dysfunction.2 Early intervention in prehypertension substantially prevents the incidence of hypertension and related damage to target organs. Currently, several strategies are used to treat prehypertension, including the incorporation of therapeutic lifestyle changes, such as healthy dietary intake and regular physical activity, as well as the use of antihypertensive drugs, such as an angiotensin II receptor blocker. Although these treatments improve prehypertension, poor compliance and limitations associated with antihypertensive medications prevent their application in the general population. Thus, there is an urgent need to identify reliable and accurate measures to prevent the development of prehypertension.Taurine (2-aminoethanesulfonic acid) is the most abundant, semiessential, sulfur-containing amino acid. It can be synthesized in vivo by cysteine in the presence of cysteine dioxygenase, 3 but taurine is mainly acquired from dietary sources, such as eggs, meat, and seafood. Hydrogen sulfide (H 2 S) is synthesized from 2 sulfur-containing amino acids, l-cysteine and l-methionine, by the 3 enzymes, cystathionine-γ-lyase (CSE), cystathionine-β-synthetase (CBS), and 3-mercaptopyruvate sulfurtransferase. 4 Taurine has several potentially beneficial cardiovascular effects that involve regulation of the nitric oxide system and endothelial function, 5,6 the renin-angiotensin-aldosteroneAbstract-Taurine, the most abundant, semiessential, sulfur-containing amino acid, is well known to lower blood pressure (BP) in hypertensive animal models. However, no rigorous clinical trial has validated whether this beneficial effect of taurine occurs in human hypertension or prehypertension, a key stage in the development of hypertension. In this randomized, double-blind, placebo-controlled study, we assessed the effects of taurine intervention on BP and vascular function in prehypertension. We randomly assigned 120 eligible prehypertensive individuals to receive either taurine supplementation (1.6 g per day) or a placebo for 12 weeks. Taurine supplementation significantly decreased the clinic and 24-hour ambulatory BPs, especially in those with high-normal BP. Mean clinic systolic BP reduction for taurine/placebo was 7.2/2.6 mm Hg, and diastolic BP was 4.7/1.3 mm Hg. Mean ambulatory systolic BP reduction for taurine/placebo was 3.8/0.3 mm Hg, and diastolic BP was 3.5/0.6 mm Hg. In addition, taurine supplementation significantly improved endothelium-dependent and endothelium-independent vasodilation and increased plasma H 2 S and taurine concentrations. Furthermore, changes in BP were negatively correlated with both the plasma H 2 S and taurine levels in taurine-treated prehypertensive individuals. To further elucidate the hypotensive mechanism, experimental studies were perfor...

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Taurine Prevents Hypertension and Increases Exercise Capacity in Rats With Fructose-Induced Hypertension

Abstract: Taurine supplementation in combination with exercise prevents hypertension and increases exercise capacity by possibly antioxidation and maintaining NO concentrations.

Cited by 26 publications

References 35 publications

Early Life Exposure to Fructose and Offspring Phenotype: Implications for Long Term Metabolic Homeostasis

Early Life Exposure to Fructose and Offspring Phenotype: Implications for Long Term Metabolic Homeostasis

Suppression of the GLUT4 adaptive response to exercise in fructose-fed rats

Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension

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