Taurine reduces caspase-8 and caspase-9 expression induced by ischemia in the mouse hypothalamic nuclei

Taranukhin, A. G.; Taranukhina, Elena Y.; Saransaari, Pirjo; Djatchkova, Irina M.; Pelto‐Huikko, Markku; Oja, Simo S.

doi:10.1007/s00726-006-0405-z

Cited by 53 publications

(26 citation statements)

References 54 publications

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“…The mechanisms involved on its actions range from increasing insulin secretion (Ribeiro et al 2009) and action ), in diabetes; reduction of hepatic cholesterol production, in hypercholesterolemia (Murakami et al 2010); and reduction of caspase-8 and -9, in ischemic neuronal apoptosis (Taranukhin et al 2008). Some of these mechanisms depend, at least in part, on the antioxidant actions of taurine (Penttila 1990;Xiao et al 2008).…”

Section: Introductionmentioning

confidence: 96%

Taurine enhances the anorexigenic effects of insulin in the hypothalamus of rats

et al. 2011

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Taurine is known to modulate a number of metabolic parameters such as insulin secretion and action and blood cholesterol levels. Recent data have suggested that taurine can also reduce body adiposity in C. elegans and in rodents. Since body adiposity is mostly regulated by insulin-responsive hypothalamic neurons involved in the control of feeding and thermogenesis, we hypothesized that some of the activity of taurine in the control of body fat would be exerted through a direct action in the hypothalamus. Here, we show that the intracerebroventricular injection of an acute dose of taurine reduces food intake and locomotor activity, and activates signal transduction through the Akt/FOXO1, JAK2/STAT3 and mTOR/AMPK/ACC signaling pathways. These effects are accompanied by the modulation of expression of NPY. In addition, taurine can enhance the anorexigenic action of insulin. Thus, the aminoacid, taurine, exerts a potent anorexigenic action in the hypothalamus and enhances the effect of insulin on the control of food intake.

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Section: Introductionmentioning

confidence: 96%

Taurine enhances the anorexigenic effects of insulin in the hypothalamus of rats

et al. 2011

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“…Taurine inhibits ischemia-induced apoptosis in rat neonatal cardiomyocytes by prevention of apoptosome assembly, cleavage and activation of caspase-3/-9 [20,21]. In mouse hypothalamic nuclei taurine reduced ischemia-induced caspase-8 and caspase-9 expression thus attenuating apoptosis [22]. It has been reported that in rat testes, pre-treatment with taurine, suppressed arsenic-induced activation of caspase-3 thus suppressing apoptosis [23].…”

Section: Cell-protective Roles Of Taurinementioning

confidence: 99%

“…This effect is manifested by attenuation of platinum (cisplatin) accumulation [24], suppression of the activation of caspase-3 [36], reduction in caspase-8 and caspase-9 expression [22], prevention of caspase-3/-9 cleavage and assembly of the apoptosome [20,21], as well as inhibition of DNA fragmentation and apoptotic cell shrinkage [25]. We find that neither taurine enrichment nor taurine depletion have any effect on the cisplatininduced caspase-3 activity, i.e., cellular taurine does not rescue EATC from cisplatin-induced apoptosis.…”

Section: Taurine and Taut In Cisplatin Resistancementioning

confidence: 99%

Pinpointing Differences in Cisplatin-induced Apoptosis in Adherent and Non-adherent Cancer Cells

Tastesen

Holm

Møller³

et al. 2010

Cell Physiol Biochem

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Platinum compounds are used in the treatment of cancer. We demonstrate that cisplatin-induced (10 µM) apoptosis (caspase-3 activity) is pronounced within 18 hours in non-adherent Ehrlich ascites tumour cells (EATC), whereas there is no increase in caspase-3 activity in the adherent Ehrlich LettrÉ ascites tumour cells (ELA). Loss of KCl and cell shrinkage are hallmarks in apoptosis and has been shown in EATC. However, we find no reduction in cell volume and only a minor loss of K⁺ which is accompanied by net uptake of Na⁺ following 18 hours cisplatin exposure in ELA. Glutathione and taurine have previously been demonstrated to protect cells from apoptosis. We find, however, that increase or decrease in the cellular content of glutathione and taurine has no effect on cisplatin-induced cell death in EATC and ELA. Nevertheless, knock-down of the taurine transporter TauT leads to a significant increase in apoptosis in ELA following cisplatin exposure. We find that cytosolic accumulation of cisplatin is similar in EATC and ELA. However, the nuclear accumulation and DNA-binding of cisplatin is significant lower in ELA compared to EATC. We suggest three putative reasons for the observed cisplatin insensitivity in the adherent tumor cells (ELA) compared to the non-adherent tumor cells (EATC): less nuclear cisplatin accumulation, increased TauT activity, and decreased anion and water loss.

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“…In the ischemic hypothalamic nucleus of mice, taurine also attenuated the expression of caspase-8 and caspase-9 (Taranukhin et al 2008 ;Leon et al 2009 ) .…”

Section: Discussionmentioning

confidence: 89%

Taurine Exerts Robust Protection Against Hypoxia and Oxygen/Glucose Deprivation in Human Neuroblastoma Cell Culture

Chen

Pan

Gharibani

et al. 2013

Advances in Experimental Medicine and Biology

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Stroke is one of the leading causes of mortality and disability worldwide. There is no effective treatment for stroke despite extensive research. Taurine is a free amino acid which is present at high concentrations in a range of organs including the brain, heart, and retina in mammalian systems. It had been shown that taurine can significantly increase cell survival under stroke conditions using both in vivo and in vitro models. Recently, we have found that several agents including granulocyte colony-stimulating factor (G-CSF), a stem cell enhancer and facilitator;S-methyl-N-diethylthiolcarbamate sulfoxide (DETC-MeSO), an NMDA receptor partial antagonist; sulindac, a potent antioxidant; and taurine, a neuroprotectant and calcium regulator, are effective in protecting against stroke-induced neuronal injury when used alone or in combination in both animal and tissue/cell culture models. In this chapter, we demonstrate that taurine can protect human neuroblastoma cells measured by ATP assay under conditions of hypoxia or oxygen/glucose deprivation (OGD). In addition, we found that taurine exerts its protective function by suppressing the OGD-induced upregulation of endoplasmic reticulum (ER) stress markers and proapoptotic proteins. A model depicting the mode of action of taurine in protecting neuroblastoma cells under OGD conditions is presented.

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Taurine reduces caspase-8 and caspase-9 expression induced by ischemia in the mouse hypothalamic nuclei

Cited by 53 publications

References 54 publications

Taurine enhances the anorexigenic effects of insulin in the hypothalamus of rats

Taurine enhances the anorexigenic effects of insulin in the hypothalamus of rats

Pinpointing Differences in Cisplatin-induced Apoptosis in Adherent and Non-adherent Cancer Cells

Taurine Exerts Robust Protection Against Hypoxia and Oxygen/Glucose Deprivation in Human Neuroblastoma Cell Culture

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