Taurine restores ethanol-induced depletion of antioxidants and attenuates oxidative stress in rat tissues

Abstract

Ethanol by its property of generating free radicals during the course of its metabolism causes damage to cell structure and function. The study investigates the protective effects of the antioxidant aminoacid taurine on ethanol-induced lipid peroxidation and antioxidant status. Male Wistar rats of body weight 170-190 g were divided into 4 groups and maintained for 28 days as follows: a control group and taurine-supplemented control group, taurine supplemented and unsupplemented ethanol-fed group. Ethanol was administered to rats at a dosage of 3 g/kg body weight twice daily and taurine was provided in the diet (10 g/kg diet). Lipid peroxidation products and antioxidant potential were quantitated in plasma and in following tissues liver, brain, kidney and heart. Increased levels of thiobarbituric acid substances (TBARS) and lipid hydroperoxides (LHP) in plasma and tissues, decreased activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were observed in hemolysate and tissues of ethanol-fed rats. The contents of reduced glutathione (GSH), alpha-tocopherol and ascorbic acid in plasma and tissues were significantly reduced in these animals as compared to control animals. Simultaneous administration of taurine along with ethanol attenuated the lipid peroxidation process and restored the levels of enzymatic and non-enzymatic antioxidants. We propose that taurine may have a bioprotective effect on ethanol-induced oxidative stress.

Effects of Benzo(a)pyrene and Ethanol on Morphology and Antioxidant Status and Transaminases in Rat Liver

“…On the other hand, in the present study GSH level of the third group is decreased and it is concordant with the literature [5][6]28]. This result might be related to either the increase in GSH oxidation, which is a direct result of increase in free radical generation or acetaldehyde promotes peroxidation reaction binding to cysteine and/or glutathione, which causes depletion of GSH [5,28]. Moreover, this result might be affected by interaction between EtOH and [B(a)P].…”

“…GSH is a non-enzymatic antioxidant which involves in the protection of normal cell structure and functions by maintenance of the redox homeostasis and participating into many detoxification processes which are catalyzed by GST and the catalytic conversion of organohydroperoxides to alcohols by GPx [5,27]. Therefore, in living organism GHS level has a critical role against the effects of oxidant substances.…”

“…it passes from the cell membrane of all body tissues and affects most vital functions of virtually all organs including liver, kidney, brain, heart and pancreas. Therefore, ethanol ingestion leads to a wide variety of pathological disturbances affecting the organs [4][5][6][7]. Moreover, its effects on the living organism are summarized in a few ways: 1.It disrupts the balance between oxidant and antioxidant enzymes which is present in living organism, 2.it induces free radical generation, 3.It has profound adverse effects on nutritional status, food consuming, digestion and absorption [4,8].…”

The Effects of Taurine on Permethrininduced Cytogenetic and Oxidative Damage in Cultured Human Lymphocytes

“…However, concentrations this high may lead to saturation. Another evidence in favour of the antioxidative action of TA is that the activities of SOD, CAT, and glutathione peroxidase (GSH-Px) normalise in TA-supplemented cultures, and this normalisation reduces LPO levels (69). The second hypothesis is that TA has a cytoprotective role.…”

Ethanol Interference on Adenosine System

“…Other neurotransmitters still present a few studies involving ethanol and the adenosine system, such as glycine, where ethanol inhibits their specific receptors probably via PKC (Tao & Ye, 2002), and taurine, which normalizes the activity of ATPases in tissues pretreated with ethanol (Pushpakiran et al, 2005), showing some indirect relationship with the system in focus.…”