Taurine Supplementation of a Premature Formula Improves Fat Absorption in Preterm Infants

Galeano, Narmer F.; Darling, Pauline B.; Lepage, Guy; Leroy, Claudie; Collet, Sylvie; Giguère, Robert; Roy, Claude

doi:10.1203/00006450-198707000-00016

Cited by 30 publications

(12 citation statements)

References 33 publications

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“…As fat soluble vitamins also enter these micelles, adding taurine to the diet theoretically could represent an advantage in improving the absorption of fat and liposoluble vitamins. It has been demonstrated that taurine supplement improves fat absorption in cystic fibrosis (20), but several studies conducted adding taurine to formulas showed conflicting results (21)(22)(23)(24). This could be explained considering the differences in taurine concentration and fatty acid composition of the formulas used.…”

Section: Discussionmentioning

confidence: 99%

Influence of dietary taurine on vitamin D absorption

et al. 1993

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To evaluate the influence of dietary taurine supplementation on vitamin D absorption, we studied three groups of infants: 21 (11 preterm) were fed a taurine-free formula, 21 (10 preterm) were fed a taurine-supplemented formula (50 mg/100 g of powder) and 20 (9 preterm) were fed human, not heat-treated milk. Taurine, total bile acids, glyco-(GBA) and tauro-(TBA) conjugated bile acids, 25-hydroxyvitamin D3 (25OHD3) and 1,25-dihydroxyvitamin D3 (1,25OH2D3) were determined in all infants at birth in blood cord and at one and three months of life. In preterm infants fed a taurine-free formula, we found lower plasma taurine levels than in infants of other groups at one and three months of life. In these infants, GBA predominated, with a G/T ratio of 1.1 and 1.4 at one and three months of life, whereas in all other infants TBA predominated with a G/T ratio always < 1. Also, 25OHD3 and 1,25OH2D3 levels were significantly lower in preterm infants fed a taurine-free formula than in infants fed a taurine-enriched formula or human milk. Term infants fed a taurine-free formula did not show differences in the parameters studied in comparison to infants of other groups. Low taurine dietary intake appears to compromise vitamin D absorption in preterm infants, and therefore taurine supplementation of preterm infant formulas should be encouraged.

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Section: Discussionmentioning

confidence: 99%

Influence of dietary taurine on vitamin D absorption

et al. 1993

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“…The fact that it is present in high concentrations in the developing brain of most species, including the human, and the finding that electroretinographic ab normalities of children maintained for prolonged periods of taurine-free parenteral nutrition can be reversed with taurine supplementation [54] suggest that taurine may be necessary for optimal central nervous system development. Lack of taurine has been suggested as a possible cause for the decreased bile salt pool size of premature infants; however, it is not clear that taurine supplementation, although pos sibly expanding bile salt pool size, improves intes tinal fat absorption [55,56].…”

Section: Smentioning

confidence: 99%

Advances in Infant Nutrition over the Past Quarter Century

Heird

1989

Journal of the American College of Nutrition

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“…Infants fed taurine supplemented formulas also have a bile salt conjugation pattern more like that of breast fed infants as well as a larger bile salt pool, but reported effects on fat absorption have been mixed. [13][14][15] Owing to the relative lack of evidence that taurine supplementation of infant formulas has beneficial clinical effects, recent recommendations for the nutrient contents of term infant formulas do not include a minimum content of taurine. 16 However, as formulas have contained taurine for almost two decades and these seem to be well tolerated, a maximum amount (12 mg/100 kcal) is specified.…”

Section: T Aurinementioning

confidence: 99%

Medication errors in the neonatal intensive care unit: special patients, unique issues

Gray

Goldmann²

2004

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Medication errors are quite common in the neonatal intensive care unit M edical errors are a common occurrence in the neonatal intensive care unit (NICU). Although this high risk, fragile patient population is prone to a wide array of errors, medication errors are particularly common. Medication errors were the most common error type submitted to the Vermont Oxford Network's NICQ.org voluntary reporting system. 1 Kaushal and colleagues 2 identified errors in 5.5% of NICU medication orders. Of note, potential adverse drug events (errors that had the potential to harm the patient but were intercepted, or potentially harmful errors that reached the patient but fortuitously did not result in injury) occurred eight times more often in NICU patients than in adults in hospital. Neonates, especially very low birthweight babies, are particularly vulnerable to adverse sequelae of medication errors as they have a limited ability to ''buffer'' such mistakes. Nursing practice has long recognised the need for extreme vigilance and a structured approach to preventing medication errors. The five ''Rights'' provide a framework for improving medication safety in nursing. These basic principles of standard operating procedure try to address all of the steps in the medication process: ordering, dispensing, administering, and monitoring drugs. Nurses attempt to ensure that the Right drug is given in the Right dose at the Right interval via the Right route to the Right patient. Although nurses focus on providing error-free care, research into human factors teaches us that dedication, training, and vigilance are not enough to prevent errors in complex systems. 3 4 Error prevention must be a multidisciplinary process, involving doctors, pharmacists, and nurses working as a team. The team must be backed up by robust healthcare delivery systems operating in a ''culture of safety'', providing staff with a working environment that provides safeguards against human fallibility. Nowhere in the hospital is the challenge greater than in the NICU.

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Taurine Supplementation of a Premature Formula Improves Fat Absorption in Preterm Infants

Cited by 30 publications

References 33 publications

Influence of dietary taurine on vitamin D absorption

Influence of dietary taurine on vitamin D absorption

Advances in Infant Nutrition over the Past Quarter Century

Medication errors in the neonatal intensive care unit: special patients, unique issues

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