Taurolidine lock solution in the secondary prevention of central venous catheter-associated bloodstream infection in home parenteral nutrition patients

Touré, Abdoulaye; Lauverjat, M.; Peraldi, C.; Boncompain-Gérard, M.; Gelas, P.; Barnoud, D.; Chambrier, C.

doi:10.1016/j.clnu.2012.01.001

Cited by 38 publications

(27 citation statements)

References 22 publications

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“…It is non-toxic to humans and is metabolised to taurine, carbon dioxide and water [35]. It has been used in both adult and paediatric patients showing promising results in oncology patients [36,37] short-gut patients [38][39][40] and haemodialysis patients [41]. Taurolock® contains 1.35% taurolidine and an anticoagulant 4% citrate.…”

Section: Time Point (Days)mentioning

confidence: 99%

Chemical stability of heparin, isopropanol, and ethanol line lock solutions

Cullis

Keene

Zaman

et al. 2015

Journal of Pediatric Surgery

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Section: Time Point (Days)mentioning

confidence: 99%

Chemical stability of heparin, isopropanol, and ethanol line lock solutions

Cullis

Keene

Zaman

et al. 2015

Journal of Pediatric Surgery

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“…Taurolidin hat ein breites antimikrobielles Wirkspektrum [82,99] bei einer minimalen Verweildauer im Katheterlumen von 4 h [81]. Taurolidin kam bisher außerhalb der Onkologie v. a. in der Hämodialyse und bei heimparenteral ernährten Patienten zum Einsatz [18,27,29,51,52,98,103]. Auch in der Kinderonkologie gibt es Patienten, die vorübergehend oder anhaltend eine heimparenterale Ernährung erhalten müssen.…”

Section: Antimikrobielle Blocklösungenunclassified

Kinderonkologie: Erhaltungspflege von Broviac- und Port-Kathetern

Scheler¹,

Simon²

2017

Krankenh.hyg. up2date

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“…Existen múltiples estudios realizados en pacientes adultos con NPD, con resultados muy positivos en cuanto a la reducción de la tasa de infección (51,61,62), especialmente en pacientes de riesgo, con infecciones de repetición. Sin embargo, cuando se ha evaluado el efecto de la taurolidina en poblaciones de pacientes con una tasa baja de infección, se ha visto que su uso no añadía ningún beneficio clínico a los sellados habituales con suero salino, siendo su coste mayor (63).…”

Section: Taurolidinaunclassified

“…Tampoco existen datos publicados sobre la periodicidad de uso de este tipo de sellados. En un estudio realizado en adultos con nutrición parenteral se vio que los sellados con taurolidina eran eficaces tanto en los pacientes en los que se administraba una vez a la semana como en aquellos que se la ponían todos los días (61). Sin embargo, el descenso en la tasa de infección fue mayor en aquellos que se ponían el sellado siempre después de la nutrición parenteral.…”

Section: Taurolidinaunclassified

Sellado con antibióticos o antisépticos en pacientes pediátricos con nutrición parenteral domiciliaria. Puesta al dí

et al. 2016

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Introduction: Home parenteral nutrition has become the mainstay for the support of patients with severe chronic intestinal failure. Despite the signifi cant advances that have occurred in recent decades in terms of vascular access and parenteral solutions, catheter-related bloodstream infections remain one of the most important complications. Antiseptic lock therapies, as ethanol or taurolidine; and antibiotic lock therapies are used in order to prevent or treat these infections. Objective: The aim of this article is to review the available scientifi c evidence regarding the use of antiseptic and antibiotic lock therapies in the management of pediatric patients with home parenteral nutrition. Material and methods: The use of ethanol or taurolidine lock therapy would be suggested in order to prevent catheter-related bloodstream infections in patients with home parenteral nutrition who have suffered from more than one infection in the previous year or in at-risk patients. Antibiotic locks are used for the treatment of catheter-related bloodstream infections due to S. coagulase negative and gram-negative bacilli in conjunction with systemic antimicrobial therapy, for whom catheter salvage is the goal. Catheter removal is recommended when there are signs of exit site or tunnel infection or the infection is due to S. aureus or Candida species. Conclusion: Despite the fact that evidence based data on the topic is scarce, there are a growing number of publications that support the use of antibiotics or antiseptic locks for the prevention or treatment of catheter-related infections in home parenteral nutrition patients, in whom catheter maintenance is a cornerstone for survival.

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Taurolidine lock solution in the secondary prevention of central venous catheter-associated bloodstream infection in home parenteral nutrition patients

Cited by 38 publications

References 22 publications

Chemical stability of heparin, isopropanol, and ethanol line lock solutions

Chemical stability of heparin, isopropanol, and ethanol line lock solutions

Kinderonkologie: Erhaltungspflege von Broviac- und Port-Kathetern

Sellado con antibióticos o antisépticos en pacientes pediátricos con nutrición parenteral domiciliaria. Puesta al dí

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