Taurolidine peritoneal lavage as prophylaxis against infection after elective colorectal surgery

Baker, DM; Jones, J. A.; Nguyen‐Van‐Tam, Jonathan S; Lloyd, Jessica; Morris, David L.; Bourke, J. B.; Steele, Robert; Hardcastle, J. D.

doi:10.1002/bjs.1800810743

Cited by 29 publications

(28 citation statements)

References 5 publications

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“…Despite the the expectactions due to the mechanism of action and the proven partial reduction of the bacterial count in the peritoneum, the outcome did not verifiably improve after a prophylactic peritoneal lavage [184], nor did it improve the outcome when treating sepsis and various forms of peritonitis [185,186,187,188], compared to rinsing with physiological NaCl solution. After a first unsuccessful treatment of septic ulcers with 0.04% PHMB or 8-quinolinol, bacteria were eliminated after changing to taurolidine 2% (soaked dressings) after 2, 6, and 7 days.…”

Section: Taurolidinementioning

confidence: 99%

Consensus on Wound Antisepsis: Update 2018

Krämer

Dissemond²,

Kim³

et al. 2017

Skin Pharmacol Physiol

256

215

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Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. In addition, systemic antibiotic therapy is required in case the infection spreads. If applied preventively, the Wounds-at-Risk Score allows an assessment of the risk for infection and thus appropriateness of the indication. The content of this updated consensus recommendation still largely consists of discussing properties of octenidine dihydrochloride (OCT), polihexanide, and iodophores. The evaluations of hypochlorite, taurolidine, and silver ions have been updated. For critically colonized and infected chronic wounds as well as for burns, polihexanide is classified as the active agent of choice. The combination 0.1% OCT/phenoxyethanol (PE) solution is suitable for acute, contaminated, and traumatic wounds, including MRSA-colonized wounds due to its deep action. For chronic wounds, preparations with 0.05% OCT are preferable. For bite, stab/puncture, and gunshot wounds, polyvinylpyrrolidone (PVP)-iodine is the first choice, while polihexanide and hypochlorite are superior to PVP-iodine for the treatment of contaminated acute and chronic wounds. For the decolonization of wounds colonized or infected with MDROs, the combination of OCT/PE is preferred. For peritoneal rinsing or rinsing of other cavities with a lack of drainage potential as well as the risk of central nervous system exposure, hypochlorite is the superior active agent. Silver-sulfadiazine is classified as dispensable, while dyes, organic mercury compounds, and hydrogen peroxide alone are classified as obsolete. As promising prospects, acetic acid, the combination of negative pressure wound therapy with the instillation of antiseptics (NPWTi), and cold atmospheric plasma are also subjects of this assessment.

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Section: Taurolidinementioning

confidence: 99%

Consensus on Wound Antisepsis: Update 2018

Krämer

Dissemond²,

Kim³

et al. 2017

Skin Pharmacol Physiol

256

215

View full text Add to dashboard Cite

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“…T also inactivates exotoxins and endotoxins [30]. Because of these properties, T is used as an antiseptic solution in the treatment of peritonitis [31] and catheter locking solution [32,33]. In dentistry, the antimicrobial effect of T was investigated and proved on several bacterial strains [34] as well as on in vivo collected supragingival plaque biofilm samples [35].…”

Section: Introductionmentioning

confidence: 99%

Taurolidine as an effective and biocompatible additive for plaque-removing techniques on implant surfaces

2014

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“…Taurolidine (TRD), a substance derived from the aminosulfoacid Taurin, was originally used in peritonitis and catheter related blood stream infections due to its anti-microbial and anti-inflammatory properties [1-3]. Over the last years, TRD has also been shown to exert anti-neoplastic activity in vitro as well as in vivo [4].…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of cell death induction by Taurolidine in different malignant human cancer cell lines

Chromik

Daigeler

Bulut

et al. 2010

J Exp Clin Cancer Res

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BackgroundTaurolidine (TRD) represents an anti-infective substance with anti-neoplastic activity in many malignant cell lines. So far, the knowledge about the cell death inducing mechanisms and pathways activated by TRD is limited. The aim of this study was therefore, to perform a comparative analysis of cell death induction by TRD simultaneously in different malignant cell lines.Materials and methodsFive different malignant cell lines (HT29/Colon, Chang Liver/Liver, HT1080/fibrosarcoma, AsPC-1/pancreas and BxPC-3/pancreas) were incubated with increasing concentrations of TRD (100 μM, 250 μM and 1000 μM) for 6 h and 24 h. Cell viability, apoptosis and necrosis were analyzed by FACS analysis (Propidiumiodide/AnnexinV staining). Additionally, cells were co-incubated with the caspase Inhibitor z-VAD, the radical scavenger N-Acetylcystein (NAC) and the Gluthation depleting agent BSO to examine the contribution of caspase activation and reactive oxygen species in TRD induced cell death.ResultsAll cell lines were susceptible to TRD induced cell death without resistance toward this anti-neoplastic agent. However, the dose response effects were varying largely between different cell lines. The effect of NAC and BSO co-treatment were highly different among cell lines - suggesting a cell line specific involvement of ROS in TRD induced cell death. Furthermore, impact of z-VAD mediated inhibition of caspases was differing strongly among the cell lines.ConclusionThis is the first study providing a simultaneous evaluation of the anti-neoplastic action of TRD across several malignant cell lines. The involvement of ROS and caspase activation was highly variable among the five cell lines, although all were susceptible to TRD induced cell death. Our results indicate, that TRD is likely to provide multifaceted cell death mechanisms leading to a cell line specific diversity.

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Taurolidine peritoneal lavage as prophylaxis against infection after elective colorectal surgery

Cited by 29 publications

References 5 publications

Consensus on Wound Antisepsis: Update 2018

Consensus on Wound Antisepsis: Update 2018

Taurolidine as an effective and biocompatible additive for plaque-removing techniques on implant surfaces

Comparative analysis of cell death induction by Taurolidine in different malignant human cancer cell lines

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