Currently, the concept of lean manufacturing has covered almost the entire global industry and all its sectors. This is due to the effectiveness of this concept, since with its application, along with increased productivity and quality, more products are produced with the same amount of resources and at lower costs. Today, lean manufacturing in the context of Industry 4.0 is relevant for achieving the principles of sustainable development. The purpose of the study is to analyze the features of lean manufacturing in the context of Industry 4.0 to achieve the principles of sustainable development. The paper considers the main theoretical aspects of the introduction of lean manufacturing in industrial enterprises and examines the essence and characteristics of Industry 4.0. Based on an expert survey, Industry 4.0 technologies have been identified for the implementation and support of lean manufacturing. The study concludes that the introduction of Industry 4.0 technologies, such as enterprise resource planning systems, industrial Internet of Things, automation and robotics, augmented and virtual reality, and radio frequency identification in industrial enterprises, into lean manufacturing not only lead to a reduction in losses but also serves as the best way to eliminate them. Flexible forecasting of changes in the supply and demand of a product helps to plan production volumes more accurately, which allows manufacturers to avoid further surpluses and losses.