Taxon-Specific Effects of Lactobacillus on Drosophila Host Development

Lee, Jaegeun; Han, Gangsik; Kim, Jae Woon; Jeon, Che Ok; Hyun, Sangwon

doi:10.1007/s00248-019-01404-9

Cited by 15 publications

(15 citation statements)

References 31 publications

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“…Many different techniques are being used to characterize the gut microbiota and untangle the complicated host–microbiota–physiology axis, with the ultimate aim of detecting causal rather than just correlational relationships, but not all can be combined with an ecological approach. Whilst gnotobiotic studies have allowed researchers to examine the physiological impact of mono‐associations and specific community compositions of microbes (Lee et al., 2020; Marques et al., 2006; Rawls et al., 2004), they are restricted to sterile laboratory environments and usually involve a limited range of model organisms (Table 1). Antibiotics can be used to examine the effect of disrupting the gut microbiota (Gao et al., 2018; Lin et al., 2015; Raymann et al., 2018; Yoon & Yoon, 2018; Zhou et al., 2018), but studies to date have focussed on the impacts on either the host or on microbial community composition.…”

Section: Future Research Directionsmentioning

confidence: 99%

The potential role of the gut microbiota in shaping host energetics and metabolic rate

Lindsay

Metcalfe

Llewellyn

2020

Journal of Animal Ecology

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1. It is increasingly recognized that symbiotic microbiota (especially those present in the gut) have important influences on the functioning of their host. Here, we review the interplay between this microbial community and the growth, metabolic rate and nutritional energy harvest of the host. How to cite this article: Lindsay EC, Metcalfe NB, Llewellyn MS. The potential role of the gut microbiota in shaping host energetics and metabolic rate.

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Section: Future Research Directionsmentioning

confidence: 99%

The potential role of the gut microbiota in shaping host energetics and metabolic rate

Lindsay

Metcalfe

Llewellyn

2020

Journal of Animal Ecology

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“…[ 15 , 18 , 52 , 65 , 66 ]. In particular, in D. melanogaster , evidence for the importance of variation between closely related bacteria is accumulating for life history of the host [ 26 , 29 , 47 – 51 , 67 ]. Unawareness of strain level variation in bacterial effects on the host might have led to perceived inconsistency between studies [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, bacteria have been identified that affect D. melanogaster phenotypes by increasing the ability for nutrient uptake [ 46 ] or metabolizing components of the food substrate, and thus modulating its nutrient content [ 24 ]. Interestingly, the metabolic potential to produce nutrients that affect fly fitness differs between closely related microbes and so do the effects on fly phenotype and fitness [ 26 , 29 , 32 , 47 – 51 ]. These findings contribute to the notion that microbial variation at taxonomically low levels is not only important for human [ 15 ], mouse [ 52 ], and plant [ 18 ] hosts, but also for Drosophila [ 53 ].…”

Section: Introductionmentioning

confidence: 99%

Horizontal gene transfer-mediated bacterial strain variation affects host fitness in Drosophila

et al. 2021

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Background How microbes affect host fitness and environmental adaptation has become a fundamental research question in evolutionary biology. To better understand the role of microbial genomic variation for host fitness, we tested for associations of bacterial genomic variation and Drosophila melanogaster offspring number in a microbial Genome Wide Association Study (GWAS). Results We performed a microbial GWAS, leveraging strain variation in the genus Gluconobacter, a genus of bacteria that are commonly associated with Drosophila under natural conditions. We pinpoint the thiamine biosynthesis pathway (TBP) as contributing to differences in fitness conferred to the fly host. While an effect of thiamine on fly development has been described, we show that strain variation in TBP between bacterial isolates from wild-caught D. melanogaster contributes to variation in offspring production by the host. By tracing the evolutionary history of TBP genes in Gluconobacter, we find that TBP genes were most likely lost and reacquired by horizontal gene transfer (HGT). Conclusion Our study emphasizes the importance of strain variation and highlights that HGT can add to microbiome flexibility and potentially to host adaptation.

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“…[15,18,52,77,78]. In particular, in D. melanogaster evidence for the importance of variation between closely related bacteria is accumulating for life history of the host [26,29,[47][48][49][50][51]79].…”

Section: Variation Between Closely Related Microbes Is Important For mentioning

confidence: 99%

“…Interestingly, the metabolic potential to produce nutrients that affect fly fitness differ between closely related microbes and so do the effects on fly phenotype and fitness [26,29,32,[47][48][49][50][51].…”

Section: Introductionmentioning

confidence: 99%

Horizontal gene transfer-mediated bacterial strain variation affects host fitness

Wang

Baumdicker

Kuenzel

et al. 2020

Preprint

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How microbes affect host fitness and environmental adaptation has become a fundamental research question in evolutionary biology. We tested for associations of bacterial genomic variation and Drosophila melanogaster offspring number in a microbial Genome Wide Association Study (GWAS). Leveraging strain variation in the genus Gluconobacter, a genus of bacteria that are commonly associated with Drosophila under natural conditions, we pinpoint the thiamine biosynthesis pathway (TBP) as contributing to differences in fitness conferred to the fly host. By tracing the evolutionary history of TBP genes in Gluconobacter, we find that TBP genes were most likely lost and reacquired by horizontal gene transfer (HGT). We suggest that HGT might contribute to microbiome flexibility and speculate that it can also more generally contribute to host adaptation.

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Taxon-Specific Effects of Lactobacillus on Drosophila Host Development

Cited by 15 publications

References 31 publications

The potential role of the gut microbiota in shaping host energetics and metabolic rate

The potential role of the gut microbiota in shaping host energetics and metabolic rate

Horizontal gene transfer-mediated bacterial strain variation affects host fitness in Drosophila

Horizontal gene transfer-mediated bacterial strain variation affects host fitness

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