Taxonomy of prokaryotic viruses: 2017 update from the ICTV Bacterial and Archaeal Viruses Subcommittee

Krupovìč, Mart; Dutilh, Bas E.; Adriaenssens, Evelien M.; Wittmann, Johannes; Vogensen, Finn K.; Sullivan, M. B.; Rumnieks, J.; Prangishvili, David; Lavigne, Rob; Kropinski, Andrew M.; Klumpp, Jochen; Gillis, Annika; Enault, François; Edwards, Robert A.; Duffy, Siobain; Clokie, Martha R. J.; Barylski, Jakub; Ackermann, Hans-Wolfgang; Kuhn, Jens H.

doi:10.1007/s00705-018-3723-z

Cited by 172 publications

(54 citation statements)

References 12 publications

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“…They integrate the classical view of antibacterial pharmacokinetics with ecological aspects of phages as a self‐replicating element of microbial communities within the body, along with characteristic responses of the body to virions . Moreover, bacteriophage is a universal name applying to the apparently most diverse entities in the world . Factors that determine phage predisposition to successfully penetrate, circulate, or rather to be promptly cleared from a system are vague, due to the extraordinary diversity of bacteriophages and to the multiplicity of possible phage applications.…”

Section: Introductionmentioning

confidence: 99%

Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review

Dąbrowska

2019

Medicinal Research Reviews

245

212

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Bacteriophages are not forgotten viruses anymore: scientists and practitioners seek to understand phage pharmacokinetics in animals and humans, investigating bacteriophages as therapeutics, nanocarriers or microbiome components. This review provides a comprehensive overview of factors that determine phage circulation, penetration, and clearance, and that in consequence determine phage applicability for medicine. It makes use of experimental data collected by the phage community so far (PubMed 1924‐2016, including non‐English reports), combining elements of critical and systematic review. This study covers phage ability to enter a system by various routes of administration, how (and if) the phage may access various tissues and organs, and finally what mechanisms determine the courses of phage clearance. The systematic review method was applied to analyze (i) phage survival in the gut (gut transit) and (ii) phage ability to enter the mammalian system by many administration routes. Aspects that have not yet been covered by a sufficient number of reports for mathematical analysis, as well as mechanisms underlying trends, are discussed in the form of a critical review. In spite of the extraordinary diversity of bacteriophages and possible phage applications, the analysis revealed that phage morphology, phage specificity, phage dose, presence of sensitive bacteria or the characteristics of treated individuals (age, taxonomy) may affect phage bioavailability in animals and humans. However, once phages successfully enter the body, they reach most organs, including the central nervous system. Bacteriophages are cleared mainly by the immune system: innate immunity removes phages even when no specific response to bacteriophages has yet developed.

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Section: Introductionmentioning

confidence: 99%

Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review

Dąbrowska

2019

Medicinal Research Reviews

245

212

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“…The prokaryotic virus community is represented in the International Committee on Taxonomy of Viruses (ICTV) by the Bacterial and Archaeal Viruses Subcommittee. Since our last report [1], the committee composition has changed, and over 200 taxonomic proposals (TaxoProps) were submitted to the ICTV Executive Committee (EC) for evaluation and approval. Below, we summarize these new developments.…”

Section: Introductionmentioning

confidence: 99%

Taxonomy of prokaryotic viruses: 2018-2019 update from the ICTV Bacterial and Archaeal Viruses Subcommittee

et al. 2020

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“…The tectiviral lineage is characterized primarily by the double jelly-roll major capsid protein (DJR MCP) that makes up the viral capsid, and the use of a specialized FtsK-HerA superfamily ATPase for DNA packaging [8]. The Tectiviridae family is currently divided into three main genera [9]. The Alphatectivirus genus was defined based on the type species Pseudomonas virus PRD1 and comprises a group of closely related virulent phages infecting a variety of Gammaproteobacteria hosts [1].…”

Section: Introductionmentioning

confidence: 99%

A Novel Genus of Actinobacterial Tectiviridae

Caruso

deCarvalho

Huynh

et al. 2019

Viruses

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Streptomyces phages WheeHeim and Forthebois are two novel members of the Tectiviridae family. These phages were isolated on cultures of the plant pathogen Streptomyces scabiei, known for its worldwide economic impact on potato crops. Transmission electron microscopy showed viral particles with double-layered icosahedral capsids, and frequent instances of protruding nanotubes harboring a collar-like structure. Mass-spectrometry confirmed the presence of lipids in the virion, and serial purification of colonies from turbid plaques and immunity testing revealed that both phages are temperate. Streptomyces phages WheeHeim and Forthebois have linear dsDNA chromosomes (18,266 bp and 18,251 bp long, respectively) with the characteristic two-segment architecture of the Tectiviridae. Both genomes encode homologs of the canonical tectiviral proteins (major capsid protein, packaging ATPase and DNA polymerase), as well as PRD1-type virion-associated transglycosylase and membrane DNA delivery proteins. Comparative genomics and phylogenetic analyses firmly establish that these two phages, together with Rhodococcus phage Toil, form a new genus within the Tectiviridae, which we have tentatively named Deltatectivirus. The identification of a cohesive clade of Actinobacteria-infecting tectiviruses with conserved genome structure but with scant sequence similarity to members of other tectiviral genera confirms that the Tectiviridae are an ancient lineage infecting a broad range of bacterial hosts.

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Taxonomy of prokaryotic viruses: 2017 update from the ICTV Bacterial and Archaeal Viruses Subcommittee

Cited by 172 publications

References 12 publications

Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review

Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review

Taxonomy of prokaryotic viruses: 2018-2019 update from the ICTV Bacterial and Archaeal Viruses Subcommittee

A Novel Genus of Actinobacterial Tectiviridae

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