TD-NMR in Quality Control: Standard Applications

Cobo, Marcio Fernando; Deublein, Eleonore J.; Haber, Agnes; Kwamen, Rance; Nimbalkar, Manoj; Decker, Frank

doi:10.1007/978-3-319-28275-6_12-1

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…Nuclear Magnetic Resonance (NMR) is an established and widely used analytical modality with many different applications in various fields of research. The non-invasive, non-destructive method has also been used in industrial quality control [ 1 , 2 , 3 ]. Low-field NMR is particularly suitable for this purpose as a cost-effective, easy-to-operate, robust and space-saving variant.…”

Section: Introductionmentioning

confidence: 99%

NMR in Battery Anode Slurries with a V-Shaped Sensor

Schmid,

Kontschak,

Nirschl

et al. 2024

Sensors

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Inline analytics in industrial processes reduce operating costs and production rejection. Dedicated sensors enable inline process monitoring and control tailored to the application of interest. Nuclear Magnetic Resonance is a well-known analytical technique but needs adapting for low-cost, reliable and robust process monitoring. A V-shaped low-field NMR sensor was developed for inline process monitoring and allows non-destructive and non-invasive measurements of materials, for example in a pipe. In this paper, the industrial application is specifically devoted to the quality control of anode slurries in battery production. The characterization of anode slurries was performed with the sensor to determine chemical composition and detect gas inclusions. Additionally, flow properties play an important role in continuous production processes. Therefore, the in- and outflow effects were investigated with the V-shaped NMR sensor as a basis for the future determination of slurry flow fields.

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Section: Introductionmentioning

confidence: 99%

NMR in Battery Anode Slurries with a V-Shaped Sensor

Schmid,

Kontschak,

Nirschl

et al. 2024

Sensors

View full text Add to dashboard Cite

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Closing the gap between in vivo and in vitro omics: using QA/QC to strengthen ex vivo NMR metabolomics

Maroli

Powers

2021

NMR in Biomedicine

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Metabolomics aims to achieve a global quantitation of the pool of metabolites within a biological system. Importantly, metabolite concentrations serve as a sensitive marker of both genomic and phenotypic changes in response to both internal and external stimuli. NMR spectroscopy greatly aids in the understanding of both in vitro and in vivo physiological systems and in the identification of diagnostic and therapeutic biomarkers. Accordingly, NMR is widely utilized in metabolomics and fluxomics studies due to its limited requirements for sample preparation and chromatography, its non‐destructive and quantitative nature, its utility in the structural elucidation of unknown compounds, and, importantly, its versatility in the analysis of in vitro, in vivo, and ex vivo samples. This review provides an overview of the strengths and limitations of in vitro and in vivo experiments for translational research and discusses how ex vivo studies may overcome these weaknesses to facilitate the extrapolation of in vitro insights to an in vivo system. The application of NMR‐based metabolomics to ex vivo samples, tissues, and biofluids can provide essential information that is close to a living system (in vivo) with sensitivity and resolution comparable to those of in vitro studies. The success of this extrapolation process is critically dependent on high‐quality and reproducible data. Thus, the incorporation of robust quality assurance and quality control checks into the experimental design and execution of NMR‐based metabolomics experiments will ensure the successful extrapolation of ex vivo studies to benefit translational medicine.

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