Tea (Camellia sinensis L. Kuntze) as Hepatoprotective Agent

Shivashankara, Arnadi Ramachandrayya; Rao, Suresh; George, Thomas; Abraham, Soniya; Colin, Marshal David; Palatty, Princy Louis; Baliga, Manjeshwar Shrinath

doi:10.1016/b978-0-12-814466-4.00015-x

Cited by 7 publications

(3 citation statements)

References 51 publications

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“…The 6-thioguanine nucleotides were assumed to promote apoptosis of activated T lymphocytes and further leads to the overactive immune defence mechanisms suppression. (32) As depicted by 6TG, 6H2MP may induce similar mechanism of action on TNF-α as stated previously, alleviating its presence. Its capability in suppressing inflammation was meticulously associated with reducing oxidative stress involving myeloperoxidase (MPO).…”

Section: Discussionmentioning

confidence: 52%

In vitro Anti-inflammatory Evaluation of 6-Thioguanine and 6-Hydroxy-2-Mercaptopurine as A Potential Treatment for Rheumatoid Arthritis

et al. 2021

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BACKGROUND: Eventhough 6-Mercaptopurine act as a major drug for rheumatoid arthritis (RA) treatment, however, its toxicity become a limitation. Therefore, this current study investigated whether 6-hydroxy-2-mercaptopurine (6H2MP) and 6-thioguanine (6TG) compounds are purine nucleoside analogues as a potential treatment of RA. The objective was to evaluate the therapeutics effects, especially the anti-inflammatory potential of 6H2MP and 6TG in the lipopolysaccharides (LPS)-induced RAW264.7 cells and phorbol myristate acetate (PMA)-induced HIG-82 cells.METHODS: Macrophage cells (RAW264.7) and rabbit synoviocytes (HIG-82) cells were induced using LPS and PMA to evaluate the anti-inflammatory potential of 6H2MP and 6TG. The cytotoxicity assessment was done by using MTT assay, while enzyme-linked immunosorbent assay (ELISA) was used to determine the anti‑inflammatory potential, including tumour necrosis factor (TNF-α), interleukins (IL-1β, and IL-6).RESULTS: Upon LPS-induced, RAW 264.7 macrophages demonstrated that 6H2MP and 6TG could suppress the production of nitric oxide (NO) in vitro. The half-maximal inhibitory concentration (IC50) value of 6TG and 6H2MP were 10.73 and 13.31, respectively. Further studied in PMA-induced HIG-82 synovial fibroblast cells showed that 6H2MP and 6TG also suppressed the release of NO, Prostaglandin E2 (PGE2), and inflammatory cytokines such as TNF-α, IL-1β and IL-6. The 6TG is more effective to reduce inflammatory reactions compared to 6H2MP, by the lower dose needed compared to 6H2MP in all experiments except in PGE2.CONCLUSION: The inhibition of inflammatory mediators is an important mechanism by which 6TG and 6H2MP may alleviate pain and articular inflammation. These results indicated that 6H2MP and 6TG are effective candidates for ameliorating inflammatory-associated complications.KEYWORDS: anti-inflammatory, HIG-82 cells, RAW264.7 cells, 6-Thioguanine, 6-Hydroxy-2-Mercaptopurine

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Section: Discussionmentioning

confidence: 52%

In vitro Anti-inflammatory Evaluation of 6-Thioguanine and 6-Hydroxy-2-Mercaptopurine as A Potential Treatment for Rheumatoid Arthritis

et al. 2021

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“…These components help in the treatment of different diseases with their different protective properties [ 146 ]. This plant is traditionally used in the treatment of flatulence, digestion, vomiting, diarrhea, maintaining body temperature, blood sugar, and in the alleviation of stomach discomfort [ 149 , 150 ]. Heteropolysaccharides extracted from C. sinensis exerted gastroprotective properties by reducing ethanol-induced gastric lesions [ 151 ].…”

Section: Plant Mediated Treatment Of Ulcer and Inflammatory Diseasesmentioning

confidence: 99%

Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

Ahmed

Rabbee

Roy

et al. 2021

Plants

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When functioning properly, the stomach is the center of both physical and mental satisfaction. Gastrointestinal disorders, or malfunctioning of the stomach, due to infections caused by various biological entities and physiochemical abnormalities, are now widespread, with most of the diseases being inflammatory, which, depending on the position and degree of inflammation, have different names such as peptic or gastric ulcers, irritable bowel diseases, ulcerative colitis, and so on. While many synthetic drugs, such as non-steroidal anti-inflammatory drugs, are now extensively used to treat these diseases, their harmful and long-term side effects cannot be ignored. To treat these diseases safely and successfully, different potent medicinal plants and their active components are considered game-changers. In consideration of this, the present review aimed to reveal a general and comprehensive updated overview of the anti-ulcer and anti-inflammatory activities of medicinal plants. To emphasize the efficacy of the medicinal plants, various bioactive compounds from the plant extract, their experimental animal models, and clinical trials are depicted.

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“…C. sinensis (L.) Kuntze has been evaluated as an effective supplement to prevent obesity [ 15 ] and treat vascular disease [ 16 ], and as a component of cosmetics to reduce skin damage [ 17 ]. The antioxidant effects of C. sinensis (L.) Kuntze have been proven through various antioxidant in vitro assays [ 18 ], while it has also been shown to exhibit antidiabetic [ 19 ], hepatoprotective [ 20 ], and component-level antibacterial effects [ 21 ]. Flavan-3-ol components have been identified, including gallocatechin, catechin, and epicatechin, in C. sinensis (L.) Kuntze extract, and these components showed outstanding bioactivity in a previous study [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Camellia sinensis (L.) Kuntze Extract Attenuates Ovalbumin-Induced Allergic Asthma by Regulating Airway Inflammation and Mucus Hypersecretion

Kang,

Kim,

Lee

et al. 2023

Pharmaceutics

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Asthma is a pulmonary disease induced by the inhalation of aeroallergens and subsequent inappropriate immune responses. Camellia sinensis (L.) Kuntze has been evaluated as an effective antioxidant supplement produced from bioactive compounds, including flavonoids. In this study, we aimed to determine the effects of Camellia sinensis (L.) Kuntze extract (CE) on ovalbumin-induced allergic asthma. The components of CE were analyzed using high-performance liquid chromatography (HPLC) chromatogram patterns, and asthmatic animal models were induced via ovalbumin treatment. The antioxidant and anti-inflammatory effects of CE were evaluated using 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS), and nitric oxide (NO) assays. Seven compounds were detected in the CE chromatogram. In the ovalbumin-induced mouse model, CE treatment significantly decreased the inflammation index in the lung tissue. CE also significantly decreased eosinophilia and the production of inflammatory cytokines and OVA-specific IgE in animals with asthma. Collectively, our results indicate that CE has anti-inflammatory and antioxidant activities, and that CE treatment suppresses asthmatic progression, including mucin accumulation, inflammation, and OVA-specific IgE production.

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Tea (Camellia sinensis L. Kuntze) as Hepatoprotective Agent

Cited by 7 publications

References 51 publications

In vitro Anti-inflammatory Evaluation of 6-Thioguanine and 6-Hydroxy-2-Mercaptopurine as A Potential Treatment for Rheumatoid Arthritis

In vitro Anti-inflammatory Evaluation of 6-Thioguanine and 6-Hydroxy-2-Mercaptopurine as A Potential Treatment for Rheumatoid Arthritis

Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

Camellia sinensis (L.) Kuntze Extract Attenuates Ovalbumin-Induced Allergic Asthma by Regulating Airway Inflammation and Mucus Hypersecretion

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