Tea polyphenols alleviates acetochlor-induced apoptosis and necroptosis via ROS/MAPK/NF-κB signaling in Ctenopharyngodon idellus kidney cells

Zhao, Xiaona; Xu, Shiwen; Liu, Qingqing; Li, Xiaojing

doi:10.1016/j.aquatox.2022.106153

Cited by 40 publications

(10 citation statements)

References 48 publications

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“…In our study, MT alleviated excessive generation of ROS and mitochondrial dysfunction in ST cells caused by TBBPA. Previous studies reported the increase of ROS level was pivotal in the induction of cell death and caused different types of cell death through activation of different signaling pathways 42,43 . PI3K/AKT signaling pathway can be activated by various types of cellular stimulation or toxic stimulation to regulate basic cellular functions.…”

Section: Discussionmentioning

confidence: 99%

The antagonistic effect of melatonin onTBBPA‐induced apoptosis and necroptosis viaPTEN/PI3K/AKTsignaling pathway in swine testis cells

Sun

Wang

Zhang

et al. 2022

Environmental Toxicology

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Tetrabromobisphenol A (TBBPA) is a widely used industrial brominated flame retardant, which can endanger animal and human health, including cytotoxicity, endocrine disruption, reproductive toxicity and so on. Melatonin (MT) is a noteworthy free radical scavenger and an antioxidant to alleviate oxidative stress. To investigate the cytotoxic of TBBPA on swine testis cells (ST cells), as well as the antagonistic effect of MT, we established TBBPA exposure and MT antagonistic models, used flow cytometry and AO/EB staining methods to detect apoptosis and necroptosis, used DCFH-DA method to examine the content of reactive oxygen species (ROS) and investigated the expression of associated genes using RT-PCR and Western blot. According to our findings, TBBPA exposure induced cell death in ST cells. TBBPA increased ROS levels, thus increasing PTEN expression and decreasing PI3K and AKT expression. Apoptosis-related factors (Caspase-3, Bax, Cyt-c, and Caspase-9) and necroptosis-related factors (RIPK1, RIPK3, and MLKL) were considerably elevated, in addition to the reduced expression of BCL-2 and Caspase-8. We also found that MT inhibited apoptosis and necroptosis in TBBPA-induced ST cells and effectively resolved the abnormal expression of related signaling pathways. In summary, the above results indicate that MT alleviates the disorder of PTEN/PI3K/AKT signaling pathway via inhibiting ROS overproduction, thereby mitigating apoptosis and necroptosis caused by TBBPA. This research provides a theoretical basis for further understanding of the toxicity of TBBPA and the detoxification of MT against environmental toxics.

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Section: Discussionmentioning

confidence: 99%

The antagonistic effect of melatonin onTBBPA‐induced apoptosis and necroptosis viaPTEN/PI3K/AKTsignaling pathway in swine testis cells

Sun

Wang

Zhang

et al. 2022

Environmental Toxicology

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“…Oxidant stress, the state of imbalance between oxidation and antioxidation, plays a crisis element in disease development, such as metabolic and viral diseases [33][34][35]. T-AOC as an important antioxidant index could reflect the state of body oxidative stress [36].…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of Yeast Culture Supplementation in the Diet of Pseudobagrus ussuriensis: Growth, Antioxidant Activity, Nonspecific Immunity, and Disease Resistance to Aeromonas hydrophila

Hou

Sun

et al. 2022

Aquaculture Nutrition

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An 8-week feeding trial was conducted to evaluate the effects of dietary yeast culture (YC) supplementation on growth performance, antioxidant activity, nonspecific immunity, and disease resistance of Pseudobagrus ussuriensis (average initial weight 6.01 ± 0.01 g ). Four isonitrogenous and isolipidic diets were formulated to contain 0 (Y0), 10 (Y1), 20 (Y2), and 30 (Y3) g/kg YC, respectively. After the feeding experiment, the challenge test of injecting Aeromonas hydrophila was executed. Results showed that appropriate YC supplementation level in the diet could improve growth performance, digestive enzyme activities, nonspecific immunity capacity, antioxidant capacity, and disease resistance of P. ussuriensis. And the highest weight gain, feed intake, specific growth rate, and IGF-1 gene expression level were observed in fish fed the Y2 diet. The activities of protease and amylase in intestine in fish fed the Y2 diet were enhanced compared with that in fish fed the Y0 diet significantly ( P < 0.05 ). Simultaneously, fish fed the Y2 diet had significantly higher serum lysozyme activity and significantly lower serum alanine amino transferase activity ( P < 0.05 ). Dietary 20 g/kg YC supplementation increased the activity of catalase and total antioxidant capacity in liver and reduced malondialdehyde content in the liver and intestine of P. ussuriensis significantly ( P < 0.05 ). Fish fed the Y2 diet had the highest disease resistance under the condition of A. hydrophila challenge ( P < 0.05 ). The quadratic regression analysis based on weight gain against dietary YC levels indicated that the appropriate dietary YC supplementation level is 13.4 g/kg diet.

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“…The neuroprotective mechanism of EGCG may depend on the regulation of MAPK and its downstream pathway. The MAPK family is composed of p38 MAPK cascades, c-Jun NH2-terminal kinases (JNK) and ERK, which are closely related to neurodegenerative diseases [ 115 ]. The function of JNK is similar to that of p38, which is related to inflammation, apoptosis and growth [ 116 , 117 ].…”

Section: Tp Suppress Brain Aging-related Signaling Pathways and Hallm...mentioning

confidence: 99%

Tea Polyphenols as Prospective Natural Attenuators of Brain Aging

Hong

Yu²,

Wang³

et al. 2022

Nutrients

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No organism can avoid the process of aging, which is often accompanied by chronic disease. The process of biological aging is driven by a series of interrelated mechanisms through different signal pathways, including oxidative stress, inflammatory states, autophagy and others. In addition, the intestinal microbiota play a key role in regulating oxidative stress of microglia, maintaining homeostasis of microglia and alleviating age-related diseases. Tea polyphenols can effectively regulate the composition of the intestinal microbiota. In recent years, the potential anti-aging benefits of tea polyphenols have attracted increasing attention because they can inhibit neuroinflammation and prevent degenerative effects in the brain. The interaction between human neurological function and the gut microbiota suggests that intervention with tea polyphenols is a possible way to alleviate brain-aging. Studies have been undertaken into the possible mechanisms underpinning the preventative effect of tea polyphenols on brain-aging mediated by the intestinal microbiota. Tea polyphenols may be regarded as potential neuroprotective substances which can act with high efficiency and low toxicity.

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Tea polyphenols alleviates acetochlor-induced apoptosis and necroptosis via ROS/MAPK/NF-κB signaling in Ctenopharyngodon idellus kidney cells

Cited by 40 publications

References 48 publications

The antagonistic effect of melatonin onTBBPA‐induced apoptosis and necroptosis viaPTEN/PI3K/AKTsignaling pathway in swine testis cells

The antagonistic effect of melatonin onTBBPA‐induced apoptosis and necroptosis viaPTEN/PI3K/AKTsignaling pathway in swine testis cells

An Evaluation of Yeast Culture Supplementation in the Diet of Pseudobagrus ussuriensis: Growth, Antioxidant Activity, Nonspecific Immunity, and Disease Resistance to Aeromonas hydrophila

Tea Polyphenols as Prospective Natural Attenuators of Brain Aging

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