With the continuous deepening of the curriculum reform process in China, various new teaching methods have gradually been applied to China's education. The problem-driven teaching method is a kind of heuristic teaching mode, which can help students to divergently thinking, boldly question and enhance students' problem awareness. Through the investigation and research on the current situation of English translation teaching in colleges and universities in China, this paper studies the professional English translation teaching mode based on problem-driven teaching method, which is intended to clarify the existing problems and try to find a solution. The teaching mode carries out reform and exploration to improve the quality of professional English translation teaching.