We identified and analyzed studies that were aimed at teaching children with autism spectrum disorder (ASD) manding skills using behavior chain interruption strategies. A systematic search of databases, reference lists, and journals identified 15 studies that met the inclusion criteria. Included studies were then summarized in terms of (a) participant characteristics, (b) dependent variables, (c) type of behavior chain interruption strategies used, (d) prompting procedures, (e) communication modality, (f) research design, (g) results, and (h) certainty of evidence. The most commonly used type of behavior chain interruption strategy was the missing item format. All of the studies used systematic prompting and fading procedures, most commonly modeling and time delay. All of the included studies reported gains in targeted communication skills. Results suggest that behavior chain interruption strategies can be effective for teaching manding skills to individuals with ASD. Implications for practitioners and suggestions for future research are discussed.