Teaching NeuroImages: Intracranial malignant triton tumor

Dias, Adriano Basso; Cambruzzi, Eduardo; Giugno, Cláudia Scherber; Curtis, Rodrigo Miranda de; Amaral, Lázaro Luís Faria do; Lenhardt, Rene

doi:10.1212/wnl.0000000000007144

Cited by 5 publications

(6 citation statements)

References 2 publications

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“…A range of cases presentation in the literature we reviewed describe the imaging manifestations (including CT and MRI) correlated with MTT: giant lump, heterogeneity, irregular margins, intratumoral hemorrhage, necrosis, lobulation, calcifications, heterogenous enhancement on postcontrast CT or MRI, hypointense/isointense T1WI and hyperintense T2WI signal on MRI, and diffusion restriction on DWI and ADC 1,8–32,39,40 . Zain et al 20 and Li et al 29 had reported similar conclusions, Li et al pointed out some characteristics common to MTTs and MPNSTs, including ill‐defined margin, intratumoral lobulation, peripheral edema, calcifications, and destruction of adjacent bone tissues.…”

Section: Discussionmentioning

confidence: 71%

“…We compiled data on reported cases of MTT in the recent 6 years (2018–2023, Table 1). 1,6–38 There were totally 37 cases with a mean age of 39.4 years (range 8 months old–75 years old), including 24 male and 13 female patients. Eleven cases originated in the abdomen (30%), 10 cases in the head and neck (27%), 8 cases in the thoracic cavity (21%), 6 cases in the limbs (16%), 1 case in the spine (3%), and 1 case in the buttocks (3%).…”

Section: Results Of Literature Reviewmentioning

confidence: 99%

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Malignant triton tumor of uterus: A case report and literature review

Jiang,

Liu,

et al. 2023

J of Clinical Ultrasound

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Malignant triton tumor (MTT) is a highly aggressive malignant neoplasm, classified as a variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. There are few reports that MTT occurred in urogenital system. In the present study, we report the first MTT occurring in the uterus. A 57‐year‐old woman came to the emergency department due to persistent vaginal bleeding for 2 months. The gynecological palpation found that a club‐shaped excrescence existed in the vagina about 7 cm × 3 cm × 3 cm. The mass located in the lower segment of the uterus and the cervix was confirmed by gynecological vaginal ultrasound and magnetic resonance imaging, which was preliminarily diagnosed as cervical carcinoma. After neoplasm punch biopsy, the pathological diagnosis was malignant triton tumor. The patient finally lost follow‐up. This is the first report about MTT in the uterus and suggests that pathological biopsy combined with imaging examination is necessary for the diagnosis of rarely MTT.

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Section: Discussionmentioning

confidence: 71%

Section: Results Of Literature Reviewmentioning

confidence: 99%

Malignant triton tumor of uterus: A case report and literature review

Jiang,

Liu,

et al. 2023

J of Clinical Ultrasound

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“…26 Our patient’s frontal lobe location for an MTT is only the second reported case in the literature. 20 …”

Section: Discussionmentioning

confidence: 99%

“…MTT managed with multiple resections and several courses of chemoradiation, with the patient having markedly improved OS compared with historical cohorts. [10][11][12][13][14][15][16][17][18][19][20][21][22] Illustrative Case A 37-year-old female with a past medical history of Hodgkin lymphoma of the chest (diagnosed at age 12), status post-chemotherapy and radiation treatment to the chest, presented to an outside hospital (OSH) with acute-onset confusion, word-finding difficulty, disorientation, and right-sided weakness. Computed tomography (CT) of the head showed a left frontal dura-based mass with associated intraparenchymal hemorrhage and surrounding vasogenic edema.…”

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confidence: 99%

Clinical diagnostic and radiographic features of recurrent intracranial malignant triton tumor in an adult: illustrative case

Chowdhury,

Belzer,

Teferi

et al. 2023

Journal of Neurosurgery: Case Lessons

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BACKGROUND Malignant triton tumors (MTTs) are a rare and aggressive type of malignant peripheral nerve sheath tumor identified histologically by focal rhabdomyoblastic differentiation. OBSERVATIONS A 37-year-old female with a prior history of Hodgkin lymphoma presented with acute-onset confusion, cognitive deficits, and weakness. Brain magnetic resonance imaging revealed a hemorrhagic intracranial mass later confirmed to be a malignant triton tumor. The patient underwent two resections and several courses of chemoradiation for multiple tumor recurrences and metastases. Unfortunately, despite extensive treatment, she died 2 years after initial presentation from complications of this tumor. Her overall survival (OS) of 26.7 months was double that reported in historical cohorts (OS ∼13 mos). LESSONS The diagnosis and treatment of central nervous system MTTs are difficult and require a multidisciplinary team of neurosurgeons, radiologists, and oncologists. Histopathological analysis is required for confirmation of diagnosis. Gross-total resection of tumor and adjuvant radiation therapy have been shown to give patients the highest rates of survival and improved outcomes. Further studies and clinical trials are warranted to investigate the efficacy of chemotherapeutic agents like temozolomide, bevacizumab, and abemaciclib.

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“…As a poorly differentiated tumor, MTT is prone to local recurrence and distant metastasis. It commonly arises from a peripheral nerve in the neck, extremities or trunk, while it is rarely found in the cranial temporal and parietal fossa, viscera, mediastinum and retroperitoneum (1). Recently, Dias et al (cited in Zhao et al) (2) have reported an uncommon case of cerebral MTT in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Intracranial Malignant Triton Tumor in Children: A Case Report

Hu¹,

He²,

Wang³

et al. 2021

Iran J Radiol

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: Malignant triton tumor (MTT) is a rare, aggressive type of tumor that commonly originates from mesenchymal tissue and is mainly found in adults. Herein, we report a single case of a 12-year-old boy diagnosed with intracranial MTT. This report presents the clinical features and imaging findings of MTT. The 12-year-old patient consulted the hospital due to intermittent dizziness and headache. Computed tomography (CT) showed low-density space-occupying lesion in the left parietal fossa. Magnetic resonance imaging (MRI) showed a mass shadow with slightly long T1 and long T2 signal intensity in the same area. Contrast enhanced MRI (CE-MRI) showed obvious enhancement of the lesion. He was diagnosed with meningioma and underwent surgery. Postoperative histopathological examination diagnosed the lesion as MTT. Two months after the operation, CT examination showed tumor recurrence. He then underwent local radiotherapy and chemotherapy, and unfortunately, died six months later. Intracranial MTT should be considered as one of the differential diagnoses of intracranial meningiomas. CT and MRI are of great significance in the identification of lesion location, invasion range, and degree of malignancy. Final diagnosis of intracranial MTT requires histopathological examination. MTT has a poor prognosis, and surgical resection of the tumor is the preferred treatment. Intervention after early diagnosis is the key to improve the outcome of patients.

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Teaching NeuroImages: Intracranial malignant triton tumor

Cited by 5 publications

References 2 publications

Malignant triton tumor of uterus: A case report and literature review

Malignant triton tumor of uterus: A case report and literature review

Clinical diagnostic and radiographic features of recurrent intracranial malignant triton tumor in an adult: illustrative case

Intracranial Malignant Triton Tumor in Children: A Case Report

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