Tear cytokine levels in the diagnosis and severity assessment of ocular chronic graft-versus-host disease(GVHD)

Hu, Bohao; Qiu, Yuan; Hong, Jing

doi:10.1016/j.jtos.2019.12.005

Cited by 40 publications

(38 citation statements)

References 38 publications

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“…[ 95 ] Though CD4+ and CD8+ T-cells are the predominant infiltrates in ocular surface tissues in chronic oGVHD,[ 96 ] it is difficult to classify it as pure T-Helper cell-1, T-Helper cell-2, or T-Helper cell-17-mediated disease. Studies evaluating tear cytokines in oGVHD found raised intercellular adhesion molecule-1 (ICAM-1),[ 97 ] interleukin-1 receptor antagonist (IL-1Ra),[ 98 ] IL-2,[ 99 ] IL-1 b,[ 97 ] IL-6,[ 9 97 99 100 ] IL-8,[ 9 85 97 98 ] IL-10,[ 9 98 99 ] IL -2AP70,[ 9 ] IL-17A,[ 9 99 ] interferon gamma (IFN- g),[ 9 99 100 ] tumor necrosis factor- a (TNF-α),[ 99 ] matrix metallopeptidase 9 (MMP-9),[ 9 101 ] and vascular endothelial growth factor (VEGF). [ 9 ] Among these IL-10, IL-6, and TNF-α, IL-8, ICAM-1, IL-12AP70, VEGF, IFN- g, and MMP-9 were found to have a fair correlation with the clinical ocular surface evaluation tests.…”

Section: Role Of Tear Biomarkers Inflammatory Mediators and Protein In Diagnosticsmentioning

confidence: 99%

“…[ 9 ] Among these IL-10, IL-6, and TNF-α, IL-8, ICAM-1, IL-12AP70, VEGF, IFN- g, and MMP-9 were found to have a fair correlation with the clinical ocular surface evaluation tests. [ 9 97 99 100 ] While these biomarkers were not raised, tear MMP 7 and MMP 9 were noted to be elevated non-oGVHD eyes post-allo-HSCT. [ 9 ] Certain tear cytokines have been proposed as possible biomarkers for chronic oGVHD (ICAM-1, IL-8, IL-1 b, IL-10, IL-17, IL-6, CXCL-10, TNF-α, MMP-9, and VEGF).…”

Section: Role Of Tear Biomarkers Inflammatory Mediators and Protein In Diagnosticsmentioning

confidence: 99%

“…[9,97–99] Comparative study of cytokines in oGVHD with non-oGVHD DED observed raised levels of ICAM-1, IL-1b, IL-6, and IL-8 and reduced levels of IL-7 and EGF. [ 97 ] Lower levels of IL-7, EGF, and IP-10 in oGVHD patients suggest a disease protective role for these mediators. [ 97 98 ] While cGVHD was conventionally thought to be T-helper cell2-mediated, recent evidence points towards the role of T-helper17 cells as key effector cells in cGVHD which is supported by raised tear levels of IL-6, IL-17 A, IL-1b, and TNF-α in oGVHD patients.…”

Section: Role Of Tear Biomarkers Inflammatory Mediators and Protein In Diagnosticsmentioning

confidence: 99%

“…[ 97 ] Lower levels of IL-7, EGF, and IP-10 in oGVHD patients suggest a disease protective role for these mediators. [ 97 98 ] While cGVHD was conventionally thought to be T-helper cell2-mediated, recent evidence points towards the role of T-helper17 cells as key effector cells in cGVHD which is supported by raised tear levels of IL-6, IL-17 A, IL-1b, and TNF-α in oGVHD patients. [ 99 102 ] IL-17A and IL-6 may also have a role in triggering proliferation and alterations of the germinal B-cell, which are now believed to influence cGVHD pathogenesis.…”

Section: Role Of Tear Biomarkers Inflammatory Mediators and Protein In Diagnosticsmentioning

confidence: 99%

See 3 more Smart Citations

Update on ocular graft-versus-host disease

Nair

Vanathi

Mukhija

et al. 2021

Indian Journal of Ophthalmology

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Ocular graft-versus-host disease (oGVHD) occurs as a complication following hematopoietic stem cell transplantation and is associated with significant ocular morbidity resulting in a marked reduction in the quality of life. With no current consensus on treatment protocols, management becomes challenging as recurrent oGVHD often refractory to conventional treatment. Most authors now diagnose and grade the disease based on criteria provided by the National Institutes of Health Consensus Conference (NIH CC) or the International Chronic oGVHD (ICCGVHD) consensus group. This article will provide an insight into the diagnostic criteria of oGVHD, its classification, and clinical severity grading scales. The inflammatory process in oGVHD can involve the entire ocular surface including the eyelids, meibomian gland, corneal, conjunctiva, and lacrimal system. The varied clinical presentations and treatment strategies employed to manage them have been discussed in the present study. The recent advances in ocular surface imaging in oGVHD patients such as the use of meibography and in vivo confocal microscopy may help in early diagnosis and prognostication of the disease. Researching tear proteomics and identification of novel potential tear biomarkers in oGVHD patients is an exciting field as they may help in objectively diagnosing the disease and monitoring the response to treatment.

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Section: Role Of Tear Biomarkers Inflammatory Mediators and Protein In Diagnosticsmentioning

confidence: 99%

Section: Role Of Tear Biomarkers Inflammatory Mediators and Protein In Diagnosticsmentioning

confidence: 99%

Section: Role Of Tear Biomarkers Inflammatory Mediators and Protein In Diagnosticsmentioning

confidence: 99%

Section: Role Of Tear Biomarkers Inflammatory Mediators and Protein In Diagnosticsmentioning

confidence: 99%

See 2 more Smart Citations

Update on ocular graft-versus-host disease

Nair

Vanathi

Mukhija

et al. 2021

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…It is a mysterious fluid found only on the ocular surface. Certain tear cytokines have been proposed as possible biomarkers for ocular GVHD due to elevated interferon-γ, intercellular adhesion molecule-1, interleukin (IL)-6, IL-8, IL-1β, IL-10, IL-17, CXCL-10, tumor necrosis factor (TNF)-α, soluble TNF -α receptor 1, and neutrophil elastase, [ 25 , 26 , 27 , 28 , 29 , 30 ], MMP-9,VEGF [ 27 ], extra DNA [ 31 ] and anti-citrullinated protein autoantibodies [ 32 ] in the tear film. The level of neutrophil elastase is reported to be correlated with the elevation of myeloperoxidase, MMP8 and MMP9, suggesting the substantial role of neutrophils in tear film in ocular GVHD [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Cascade of Inflammatory, Fibrotic Processes, and Stress-Induced Senescence in Chronic GVHD-Related Dry Eye Disease

Ogawa

Kawakami

Ohta

2021

IJMS

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Ocular graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation. Ocular GVHD affects recipients’ visual function and quality of life. Recent advanced research in this area has gradually attracted attention from a wide range of physicians and ophthalmologists. This review highlights the mechanism of immune processes and the molecular mechanism, including several inflammation cascades, pathogenic fibrosis, and stress-induced senescence related to ocular GVHD, in basic spectrum topics in this area. How the disease develops and what kinds of cells participate in ocular GVHD are discussed. Although the classical immune process is a main pathological pathway in this disease, senescence-associated changes in immune cells and stem cells may also drive this disease. The DNA damage response, p16/p21, and the expression of markers associated with the senescence-associated secretory phenotype (SASP) are seen in ocular tissue in GVHD. Macrophages, T cells, and mesenchymal cells from donors or recipients that increasingly infiltrate the ocular surface serve as the source of increased secretion of IL-6, which is a major SASP driver. Agents capable of reversing the changes, including senolytic reagents or those that can suppress the SASP seen in GVHD, provide new potential targets for the treatment of GVHD. Creating innovative therapies for ocular GVHD is necessary to treat this intractable ocular disease.

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Unrevealing the connection between real sample analysis and analytical method. The case of cytokines

Irimes

Tertiş

Oprean

et al. 2023

Medicinal Research Reviews

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Cytokines are compounds that belong to a special class of signaling biomolecules that are responsible for several functions in the human body, being involved in cell growth, inflammatory, and neoplastic processes. Thus, they represent valuable biomarkers for diagnosing and drug therapy monitoring certain medical conditions. Because cytokines are secreted in the human body, they can be detected in both conventional samples, such as blood or urine, but also in samples less used in medical practice such as sweat or saliva. As the importance of cytokines was identified, various analytical methods for their determination in biological fluids were reported. The gold standard in cytokine detection is considered the enzyme‐linked immunosorbent assay method and the most recent ones have been considered and compared in this study. It is known that the conventional methods are accompanied by a few disadvantages that new methods of analysis, especially electrochemical sensors, are trying to overcome. Electrochemical sensors proved to be suited for the elaboration of integrated, portable, and wearable sensing devices, which could also facilitate cytokines determination in medical practice.

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Tear cytokine levels in the diagnosis and severity assessment of ocular chronic graft-versus-host disease(GVHD)

Cited by 40 publications

References 38 publications

Update on ocular graft-versus-host disease

Update on ocular graft-versus-host disease

Cascade of Inflammatory, Fibrotic Processes, and Stress-Induced Senescence in Chronic GVHD-Related Dry Eye Disease

Unrevealing the connection between real sample analysis and analytical method. The case of cytokines

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