Tear film and ocular surface dysfunction in diabetes mellitus in an Indian population

Kesarwani, Divya; Rizvi, Syed Wajahat Ali; Khan, Adeeb Alam; Amitava, Abadan K; Vasenwala, Shaista M; Siddiqui, Ziya

doi:10.4103/ijo.ijo_939_15

Cited by 29 publications

(13 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study conducted by Kesarwani et al found a decreased tear secretion in diabetics with diabetic retinopathy. 9 Our study also supports a similar finding. The Schirmers strips showed decreased measurements of wetting as the severity of the stages of DR increased.…”

Section: Discussionsupporting

confidence: 91%

Tear film changes in diabetic retinopathy: A hospital based case control study

Shetgar¹,

Viswanathan²,

Patil³

et al. 2020

IJCEO

View full text Add to dashboard Cite

To compare the tear film changes in diabetic population with and without diabetic retinopathy.To study the association of dry eye with different gradings of diabetic retinopathy.A case control study was conducted in 112 eyes in diabetics with and without diabetic retinopathy changes. Tests for tear film changes like Schirmers, TBUT and KES was conducted and the results were compared.The mean value of Schirmer in diabetic retinopathy group was 10.84 +/- 4.785, mean value of TBUT was 7.73+/- 2.908 and that of KES was 1.34 +/- 0.745 whereas mean value of Schirmers in non DR group was 12.84+/- 2.947, that of TBUT was 10.43+/- 2.035 and that of KES was 0.73+/- 0.726. Significantly poorer Schirmers (p= 0.009), TBUT (p=0.001) and KES(p=0.001) was found in the DR group.With increasing severity of diabetic retinopathy these signs and symptoms of dry eye have found to increase thereby a significant association between dry eye and grading of DR.

show abstract

Section: Discussionsupporting

confidence: 91%

Tear film changes in diabetic retinopathy: A hospital based case control study

Shetgar¹,

Viswanathan²,

Patil³

et al. 2020

IJCEO

View full text Add to dashboard Cite

show abstract

“…These findings are close to those conducted by Zhang and Leiden (Van Leiden et al, 2002;Zhang et al, 2018). However, a correlation between tear film abnormality and DR has also been described in the literature (Nepp et al, 2000;Kesarwani et al, 2017).…”

Section: Discussionsupporting

confidence: 90%

Level of VEGF-A and interleukin 6 in lacrimal fluid of patients with diabetic retinopathy

Domngang¹,

Noutchie²,

Chuisseu³

et al. 2020

Int. J. Bio. Chem. Sci

View full text Add to dashboard Cite

Diabetic retinopathy (DR) is an ocular manifestation characterized by microvascular complications. The aim of this study was to investigate the relationship between diabetic retinopathy (DR) and two lacrimal angiogenic cytokines, interleukin-6 (Il-6) and vascular endothelial growth factor-A (VEGF-A). A cross-sectional study was conducted at Yaoundé Central Hospital from February,1 to June, 15, 2019. Twenty-six diabetic patients with retinopathy and 55 diabetics without retinopathy were enrolled. Tears were collected with Schirmer strips. The concentrations of VEGF-A and Il-6 were determined by the ELISA test. Statistical analysis was performed using Epi Data version 7.1.5.2. and GraphPad 5.0. The mean VEGF-A concentration was 163.4 ± 45.1 and 149± 81.8 pg/ml in patients with and without DR respectively (p= 0.292) while tear Il-6 level was 118.5±103 and 119±79.43 pg/ml in patients with and without DR respectively (p= 0.497). The mean tear VEGF level was 165.2 ± 76.10 and 153.50 ± 57.94 pg/mL in patients with and without diabetic maculopathy (DM) respectively (p=0.343) while tear Il-6 level was significantly lower in DM (54.92±32.68) compared to patients without DM (159.10±89.78) (p=0.047). Tear Il-6 level was significantly low in patients with DM. There was no association between the 2 lacrimal biomarkers and diabetic retinopathy. Further analysis is needed for this type of screening in diabetic patients.Keywords: eye, retina, tear, diabetes, biomarker; cytokine.

show abstract

“…Tear film abnormalities in patients with DM occur due to poor quantity and quality of tears, combined with a subnormal ocular surface. [ 15 16 17 18 ] In this study, Group 1 patients had a higher OSDI score and a significantly lower mean Schirmer, TBUT, and abnormal OSS value compared to controls. Patients with proliferative diabetic retinopathy had more severe symptoms of DED and higher OSS consistent with other studies.…”

Section: Discussionmentioning

confidence: 48%

Ocular surface disorder among adult patients with type II diabetes mellitus and its correlation with tear film markers

Manchikanti

Kasturi

Rajappa

et al. 2021

Taiwan Journal of Ophthalmology

View full text Add to dashboard Cite

PURPOSE: The purpose is to study the ocular surface changes among patients with diabetes mellitus (DM) and to correlate them with tear film markers such as insulin-like growth factor (IGF)-1, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α levels. MATERIALS AND METHODS: The study was carried out on diabetic patients (>5 years' duration) and healthy age- and gender-matched controls with 21 individuals in each group. Schirmer's test for basal and reflex tear secretion, tear film breakup time (TBUT) for tear stability, ocular staining score (OSS) for dryness severity, ocular surface disease index (OSDI) for symptomatic assessment of dryness and conjunctival impression cytology (IC) for epithelial cell integrity, keratinization, squamous metaplasia, and goblet cell density was studied. Thirty microliters of tears were collected to test IGF-1, IL-1β, and TNF-α levels. RESULTS: Patients with DM showed significantly low Schirmer's, TBUT, and OSS values than controls. OSDI score showed moderate-severe dryness in patients with DM and only mild symptoms among controls. An abnormal IC score was seen among cases and controls. The level of TNF-α was significantly increased in patients with DM and positively correlated with Schirmer and TBUT values ( P < 0.05). CONCLUSION: Dry eye is more prevalent in patients with DM compared to controls as evidenced by poor OSDI score, Schirmer, TBUT, and OSS. TNF-α in the tears of patients with DM is a useful marker that showed a good correlation with Schirmer, TBUT, and dry eye symptoms. IC could not conclusively differentiate the dry eye status in patients with DM from controls.

show abstract

Tear film and ocular surface dysfunction in diabetes mellitus in an Indian population

Cited by 29 publications

References 11 publications

Tear film changes in diabetic retinopathy: A hospital based case control study

Tear film changes in diabetic retinopathy: A hospital based case control study

Level of VEGF-A and interleukin 6 in lacrimal fluid of patients with diabetic retinopathy

Ocular surface disorder among adult patients with type II diabetes mellitus and its correlation with tear film markers

Contact Info

Product

Resources

About