Tear meniscus, corneal topographic and aberrometric changes after botulinum toxin-a injection in patients with blepharospasm and hemifacial spasm

Bilen, Neslihan Bayraktar; Bilen, Şule; Topçu-Yılmaz, Pınar; Kemer, Özlem Evren

doi:10.1007/s10792-022-02253-1

Int Ophthalmol

2022

DOI: 10.1007/s10792-022-02253-1

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Tear meniscus, corneal topographic and aberrometric changes after botulinum toxin-a injection in patients with blepharospasm and hemifacial spasm

Neslihan Bayraktar Bilen

Şule Bilen

Pınar Topçu-Yılmaz³

et al.

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Cited by 4 publications

(2 citation statements)

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“…1,[6][7][8] However, the effect of BTX-A injections on the ocular surface remains controversial: while some studies reported improvement, some reported worsening or no change in tear film parameters after BTX-A applications. [8][9][10][11][12][13][14][15][16] In this study, the authors aimed to objectively assess EB patients regarding the effect of botulinum toxin injections on the ocular surface, assessing tear meniscus area with optical coherence tomography. Break-up time (BUT), Schirmer test, and the Ocular Surface Disease Index (OSDI) questionnaire were also evaluated at baseline and after BTX-A injections.…”

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confidence: 99%

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Ocular Surface Metrics in Blepharospasm Patients After Treatment With Botulinum Toxin Injections

Yabumoto

Osaki

Gameiro

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose:The purpose of this study was to assess blepharospasm patients regarding the effect of botulinum toxin in ocular surface parameters.Methods: A prospective study was performed in blepharospasm patients treated with onabotulinumtoxinA. A smartphone (iPhone 6S, Apple) and custom-made software were used to record the eyelid movements for 3 minutes in a standardized manner. Optical coherence tomography of the tear meniscus was used to assess the tear meniscus area. Tear break-up time and the Ocular Surface Disease Index questionnaire were also evaluated. Patients were assessed before and 15 days after botulinum toxin injections.Results: Forty eyes of 20 patients were evaluated. The frequency of the spontaneous eyelid movements was significantly reduced after treatment (23.18 ± 12.85 movements/ min vs. 9.29 ± 6.87 movements/min; p < 0.0001). Significant increases in the tear meniscus area (0.020 ± 0.015 mm 2 vs. 0.057 ± 0.104 mm 2 ; p = 0.01) and in break-up time (4.2 ± 1.2 seconds vs. 5.1 ± 1.3 seconds; p = 0.03) were observed 15 days after treatment. A significant reduction in the Ocular Surface Disease Index (59.05 ± 19.04 vs. 21.2 ± 19.5; p < 0.0001) was also observed.Conclusion: Significant changes in the tear meniscus area, break-up time, and Ocular Surface Disease Index after treatment reflect the effect of botulinum toxin on the lacrimal pump and in the improvement of dry eye symptoms. Reduction of eyelid spasms after treatment in blepharospasm patients was demonstrated using a smartphone and custom-made software. Thus, beyond relieving eyelid spasms, botulinum toxin injections were associated with subjective and objective improvement of dry eye parameters in patients with blepharospasm.

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mentioning

confidence: 99%

“…1,6–8 However, the effect of BTX-A injections on the ocular surface remains controversial: while some studies reported improvement, some reported worsening or no change in tear film parameters after BTX-A applications. 8–16…”

mentioning

confidence: 99%

Ocular Surface Metrics in Blepharospasm Patients After Treatment With Botulinum Toxin Injections

Yabumoto

Osaki

Gameiro

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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show abstract

Does blepharospasm effect biometric parameters and intraocular lens power calculations?

Basol,

Ilhan

2024

Int Ophthalmol

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Objective assessment of tear film in blepharospasm, facial hemispam and aberrant regeneration with periocular botulinum toxin-A

Galindo-Ferreiro,

Fraile García,

Schellini

et al. 2024

European Journal of Ophthalmology

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Purpose Study the effect on the tear film in blepharospasm (BEB), facial hemispasm (FH), or aberrant regeneration (AR) treated with Botulinum Toxin (BTX-A). Methods A prospective study was used to evaluate the tear film in patients with BEB, FH, or AR treated with BTX-A. Schirmer tests, break-up time (BUT), optical coherence tomography (OCT) meniscus measurement, the Ocular Surface Disease Index (OSDI) questionnaire, and Oxford scale were documented before; 1 month after; and 3 months after BTX-A treatment. Comparisons were made with the Friedman test and Wilcoxon matched-pairs signed rank test was used. A p-value <0.05 was considered statistically significant. Results A total of 35 eyes from 27 patients were included. The mean patient age was 66.81 ± 12.94 years and 18 (66.7%) were female. Ten (37%) patients had BEB, six (22.2%) had FH, and 11 (40.74%) had AR. BTX-A improved the lid spasms. One month after BTX-A, Schirmer tests showed slight increments (Schirmer 1 p = 0.009; Schirmer 2 p = 0.05) and at 3 months they became similar to pre-treatment ( p = 0.5). The BUT test was not significantly different at 1 month ( p = 0.450) or at 3 months. On OCT 1 month after BTX-A, there was an increase in tear meniscus area ( p = 0.004), height ( p = 0.007), and depth ( p = 0.004), and at 3 months the measurements also became similar to the pre-BTX-A values. No significant changes in the OSDI ( p = 0.717) and Oxford scale ( p = 0.255). Conclusion OCT is a good tool to detect the increase in tear meniscus after periocular BTX-A in BEB, FH, and AR.

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Tear meniscus, corneal topographic and aberrometric changes after botulinum toxin-a injection in patients with blepharospasm and hemifacial spasm

Cited by 4 publications

References 44 publications

Ocular Surface Metrics in Blepharospasm Patients After Treatment With Botulinum Toxin Injections

Ocular Surface Metrics in Blepharospasm Patients After Treatment With Botulinum Toxin Injections

Does blepharospasm effect biometric parameters and intraocular lens power calculations?

Objective assessment of tear film in blepharospasm, facial hemispam and aberrant regeneration with periocular botulinum toxin-A

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