Purpose: To compare optical coherence tomography measurements; central macular thickness, ganglion cell complex, and retinal nerve fiber layer thickness in patients with epilepsy versus healthy controls. Methods: We evaluated 28 eyes of 28 patients with epilepsy and 34 eyes of 34 healthy subjects. Central macular thickness, ganglion cell complex, and retinal nerve fiber layer thickness measurements were performed by spectral-domain optical coherence tomography. Results: Superior and superotemporal quadrant ganglion cell complex, average, and superior quadrant retinal nerve fiber layer thickness measurements were significantly lower in epilepsy group compared to healthy control subjects. Central macular thickness was significantly lower in polytherapy group compared to monotherapy group. Ganglion cell complex and retinal nerve fiber layer thickness measurements were not significantly different between polytherapy and monotherapy groups. Conclusion: The present study shows that epileptic patients taking antiepileptic drugs have reduced ganglion cell complex and retinal nerve fiber layer thickness compared to healthy controls. This can be related to the epileptic process in the brain. Optical coherence tomography may be a useful tool for showing the neurodegeneration in patients with epilepsy.
In this study, CS is more affected than CDVA as a visual function. The quantity and quality of vision is significantly correlated with well-known and new topographic indices. There is not a significant correlation between visual function and pachymetric parameters. The significantly correlated indices can be used in staging keratoconus and to follow the outcome of a treatment.
Background: Cataract surgery has been an independent risk factor in the development and progression of age-related macular degeneration. Understanding the relationship between cataract surgery and Macular Pigment Optical Density (MPOD) will be helpful for the prevention of this degeneration during follow-up. The present study is aimed to evaluate effectiveness of lens status and postoperative period over MPOD. Method: Patients were divided into 2 groups, including phakic cases that have transparent natural lens and pseudophakic cases that had undergone cataract surgery at least a year prior. MPOD values were measured by a heterochromatic flicker photometric method and assessed for each group. Results: Sixty eyes of 31 cases were enrolled in the study. As group-1 included 30 eyes of 15 phakic cases; group 2 included 30 eyes of 16 pseudophakic cases. The mean MPOD values were 0.572 ± 128 and 0.549 ± 219 in groups 1 and 2, respectively. The mean MPOD values of phakic and pseudophakic patients were statistically similar (p>0.05). However, the MPOD values and duration of postoperative period of the patients in group-2 showed a significant negative correlation (r=-0.443, p<0.05). Conclusion: The outcome of macular pigment optical density was similar in both phakic and pseudophakic eyes. Although an inverse correlation exists between the duration of the postoperative period after cataract surgery and MPOD values, our results supports that cataract surgery has no potential effects on macular degeneration at least done for a year.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.