Tec Family Kinases in Inflammation and Disease

Horwood, Nicole J.; Urbaniak, Ania M.; Danks, L

doi:10.3109/08830185.2012.670334

Cited by 64 publications

(43 citation statements)

References 135 publications

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“…Levels of activated, phosphorylated (p-) PKB are elevated in RA versus non-RA synovial tissue, and PKB-dependent phosphorylation of FoxO4 in synovial macrophages, particularly in the synovial sublining, is significantly enhanced in RA 5 6. Tec family kinases include Tec, Bruton's tyrosine kinase (Btk), Itk, Bmx and Rlk 7. Complete activation of Tec family kinases upon cell-surface receptor triggering requires PI3K-dependent relocalisation of the protein to the plasma membrane, subsequent phosphorylation by a Src family kinase, and finally autophosphorylation 8.…”

Section: Introductionmentioning

confidence: 99%

Btk inhibition suppresses agonist-induced human macrophage activation and inflammatory gene expression in RA synovial tissue explants

Hartkamp

Fine

et al. 2014

Ann Rheum Dis

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Section: Introductionmentioning

confidence: 99%

Btk inhibition suppresses agonist-induced human macrophage activation and inflammatory gene expression in RA synovial tissue explants

Hartkamp

Fine

et al. 2014

Ann Rheum Dis

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“…ITK and RLK play critical roles in T-cell-driven inflammation (43). Therefore, we tested the effect of PRN694 in an oxazolone-induced DTH reaction, a well established in vivo model of inflammation driven by cell-mediated immunity.…”

Section: Prn694 Attenuates Tcr-induced Activation Of T-cell Prolymphomentioning

confidence: 99%

“…are critically important for the production of proinflammatory cytokines and inflammatory disease (43). We sought to examine the effect of PRN694 on proinflammatory cytokine production.…”

Section: Prn694 Inhibits Proinflammatory Cytokine Release By Primary mentioning

confidence: 99%

Targeting Interleukin-2-inducible T-cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694

Zhong

Dong

Strattan

et al. 2015

Journal of Biological Chemistry

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Background: ITK and RLK are unique to effector lymphocytes and critical for immune activation. Results: A novel selective covalent ITK/RLK inhibitor called PRN694 was discovered, which blocks T-cell and NK cell activation. Conclusion: PRN694 provides an effective tool to elucidate the roles of ITK and RLK in immune cell signaling. Significance: PRN694 could be an effective therapy for T-cell-or NK cell-driven autoimmune, inflammatory, and malignant diseases.

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“…Further B cell directed therapies are in development although how much of their effect is due to an overall reduction inflammation (Bluml et al, 2013;Horwood et al, 2012) as opposed to direct effects on osteoclasts and osteoblasts remains to be determined.…”

Section: B Cells and Bonementioning

confidence: 97%

Immune cells and bone: coupling goes both ways

Horwood¹

2013

Immunological Investigations

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There is a mounting body of research describing how cells of the immune system direct bone cell function whilst bone cells are involved in the generation and retention of immune cells and their precursors. Recent works into regulation of the haemopoietic stem cell niche have firmly implicated osteoblasts and osteoclasts. On the other hand, virtually all of the mature immune cells have been described to influence bone formation in vitro and in vivo. This review will summarize the latest developments and discuss the importance of the coupling of bone formation to resorption when considering the contributions from cells of the immune system.

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Tec Family Kinases in Inflammation and Disease

Cited by 64 publications

References 135 publications

Btk inhibition suppresses agonist-induced human macrophage activation and inflammatory gene expression in RA synovial tissue explants

Btk inhibition suppresses agonist-induced human macrophage activation and inflammatory gene expression in RA synovial tissue explants

Targeting Interleukin-2-inducible T-cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694

Immune cells and bone: coupling goes both ways

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