Technetium-99m hexamethyl propylene amine oxime-labeled leukocyte scintigraphy at three different times in active ulcerative colitis: comparison with colonoscopy and clinico-biochemical parameters in the assessment of disease extension and severity

Aydın, Funda; Dinçer, Dinç; Güngör, Fırat; Boz, Adil; Akça, Serdar; Yıldız, Akın; Tosun, Özgür; Karayalçın, Binnur

doi:10.1007/s12149-008-0131-6

Cited by 12 publications

(7 citation statements)

References 31 publications

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“…The 99m Tc-HMPAO WBC scintigraphy as an alternative to the invasive gold standard represented by endoscopy with biopsy is a reliable method both for diagnosis and follow-up in pediatric inflammatory bowel disease (IBD) (36,37). Just a few studies about pediatric patients can be found in the literature, and the results of these studies showed sensitivity between 84% and 93%, specificity between 81% and 93% in the diagnosis of IBD (38,39).…”

Section: Discussionmentioning

confidence: 99%

“…Just a few studies about pediatric patients can be found in the literature, and the results of these studies showed sensitivity between 84% and 93%, specificity between 81% and 93% in the diagnosis of IBD (38,39). The 99m Tc-HMPAO labeled WBC scintigraphy has proved itself in correctly defining IBD remission and relapses and in defining lesions location, extension, and severity (37). In children with possible IBD the 99m Tc-HMPAO labeled WBC scintigraphy, when compared with endoscopy and biopsy, has a sensitivity rate of 93%, a specificity rate of 97% (38).…”

Section: Discussionmentioning

confidence: 99%

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Tc-99m Labeled HMPAO white Blood Cell Scintigraphy in Pediatric Patients

Aydın

Cengiz²,

Güngör³

2012

Mirt

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Objective: 99mTc labeled hexamethylpropylene amine oxime (HMPAO) white blood cell (WBC) scintigraphy is a frequently used option for acute infection, particularly in pediatric patients. This scintigraphy is applied to detect sites of infection/inflammation in patients with fever of unknown origin, to find and follow up osteomyelitis, and to detect suspicion of acute appendicitis. The aim of this retrospective study was to evaluate the value of 99mTc-HMPAO labeled WBC scintigraphy in pediatric patients.Material and Methods: The study was conducted between January 2006 and December 2008 and included 13 patients (5 boys, 8 girls; mean age 6.9±6.2 years). Those patients who had suspicion of bone infection (n=7), fever of unknown origin (n=3), and suspicion of acute appendicitis (n=3) were evaluated retrospectively. 99mTc-HMPAO labeled WBC scintigraphy imaging was performed to all patients. Diagnosis was done according to operation and pathological results or clinical follow-up.Results: 99mTc-HMPAO labeled WBC scintigraphy has been found to be true positive in 6 cases, true negative in 6 cases, and false negative in one patient who had fewer unknown origin. The false negative case has been found to have encephalitis with MRI. Conclusion: Leukocyte scintigraphy has been described as a useful diagnostic tool in the diagnosis of suspicion of bone infection, fever of unknown origin and suspicion of acute appendicitis. 99mTc-HMPAO labeled WBC scintigraphy is a rapid and very accurate method for detecting those pathologies. Our results showed that WBC scintigraphy might be reliably used for diagnosis of suspected bone infection and acute appendicitis, fever of unknown origin, and acute appendicitis, in pediatric patient population.Conflict of interest:None declared.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Tc-99m Labeled HMPAO white Blood Cell Scintigraphy in Pediatric Patients

Aydın

Cengiz²,

Güngör³

2012

Mirt

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“…The response to an inflammation or acute infection process is characterized by an increase in the local amount of blood, increased vascular permeability in addition to plasma protein exudation, and leukocyte stream [65]. …”

Section: 99mtc-hmpao-labeled Leukocyte Scintigraphy (Tlls)mentioning

confidence: 99%

“…It also demands trained staff, well-equipped laboratories for cell labeling in aseptic conditions not to mention longer performing times. The undeniable advantage of in vitro labeling is, however, given by its distinctly higher image quality due to a selective labeling of granulocytes with lower residual [65]. …”

Section: 99mtc-hmpao-labeled Leukocyte Scintigraphy (Tlls)mentioning

confidence: 99%

“…Moreover, 99mTc-HMPAO manages to visualize only acute inflammatory cases and may show false positives ( Yersinia enteritis, ischemic colitis, tubercular enteritis, rejection, pseudomembranous colitis, vasculitis, appendicitis, hematomas, radiation enteritis, malignant pathologies with necrotic component). Crohn's disease case studies in nontreated patients report sensitivity percentage values of 83–98% and specificity percentage values of 92–100% [64, 65]; particularly in Crohn's disease diagnosis sensitivity percentage amounts to 90%, specificity to 93 [8]; in postsurgical recurrences, diagnostic accuracy percentage amounts to 81.3–81.8% [23]. …”

Section: 99mtc-hmpao-labeled Leukocyte Scintigraphy (Tlls)mentioning

confidence: 99%

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Crohn’s Disease Imaging: A Review

Gatta

Grezia

Mizio³

et al. 2012

Gastroenterology Research and Practice

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Crohn’s disease is a chronic granulomatous inflammatory disease of the gastrointestinal tract, which can involve almost any segment from the mouth to the anus. Typically, Crohn’s lesions attain segmental and asynchronous distribution with varying levels of seriousness, although the sites most frequently involved are the terminal ileum and the proximal colon. A single gold standard for the diagnosis of CD is not available and the diagnosis of CD is confirmed by clinical evaluation and a combination of endoscopic, histological, radiological, and/or biochemical investigations. In recent years, many studies have been performed to investigate the diagnostic potential of less invasive and more patient-friendly imaging modalities in the evaluation of Crohn’s disease including conventional enteroclysis, ultrasonography, color-power Doppler, contrast-enhanced ultrasonography, multidetector CT enteroclysis, MRI enteroclysis, and 99mTc-HMPAO-labeled leukocyte scintigraphy. The potential diagnostic role of each imaging modality has to be considered in different clinical degrees of the disease, because there is no single imaging technique that allows a correct diagnosis and may be performed with similar results in every institution. The aim of this paper is to point out the advantages and limitations of the various imaging techniques in patients with suspected or proven Crohn’s disease.

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Synthesis, Structure and Reactions of Organometallic Derivatives of Oximes

Абеле

Lukevics

2010

Patai's Chemistry of Functional Groups

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Organometallic derivatives of oximes were reviewed. These derivatives were selected and presented according to the place of the metal in the periodic table. Formation and reactions of disalts of oximes of type RC(CHMR′)=NOM (R, R′ = H, alkyl, aryl) and monosalts of oximes of type RC(CHMR′)=NOR″ (R″ = alkyl, aryl, M = alkali metal) were presented. Synthesis and reactions of silicon, germanium, tin, phosphorus containing oximes were included too. Beside this, oxime metal derivatives (for example, oxime palladacycles) as valuable catalysts in organic synthesis were described. In addition, oxime metal complexes exhibit wide spectrum of biological activity. Using of technetium‐99m hexamethylpropyleneamineoxime (Ceretec TM ) and related oxime complexes in diagnosis was described. Silicon and tin oxime complexes as excellent agrochemical agents were presented. Some cobalt, platinium and silicon containing oxime ethers exhibit high antitumor and cytotoxic activity and will be perspective targets for the further investigations. Introduction Synthesis, Structure and Reactions of Organometallic Derivatives of Oximes Conclusions

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Technetium-99m hexamethyl propylene amine oxime-labeled leukocyte scintigraphy at three different times in active ulcerative colitis: comparison with colonoscopy and clinico-biochemical parameters in the assessment of disease extension and severity

Cited by 12 publications

References 31 publications

Tc-99m Labeled HMPAO white Blood Cell Scintigraphy in Pediatric Patients

Tc-99m Labeled HMPAO white Blood Cell Scintigraphy in Pediatric Patients

Crohn’s Disease Imaging: A Review

Synthesis, Structure and Reactions of Organometallic Derivatives of Oximes

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