Technetium-99m hexamethylpropylene amine oxime labelled leucocyte scintigraphy in ulcerative colitis and Crohn's disease

Abstract

Technetium-99m hexamethylpropylene amine oxime labelled leucocyte scintigraphy (LS) was performed on 45 occasions in 30 patients with ulcerative colitis and on 53 occasions in 34 patients with Crohn's disease. Serial images were taken following re-injection of the labelled leucocytes. The segmental extent of the inflammation and the grade of the leucocyte uptake were calculated, and compared with the laboratory results and colonoscopy findings. The sensitivity and specificity of LS proved higher in ulcerative colitis (87% and 93%) than in Crohn's disease (53% and 89% in cases with large intestine involvement, and 82% and 100% in cases with small intestine involvement). The activity of the process determined by LS correlates with the alpha 2-globulin level (r = 0.47), fibrinogen level (r = 0.50), fS iron level (r = -0.57), sedimentation (r = 0.44), leucocyte count (r = 0.38), platelet count (r = 0.34) and Best index (r = 0.31) in ulcerative colitis, but not in Crohn's disease.

Labelled leucocyte scintigraphy in inflammatory bowel disease: clinical applications.

“…15 17 20 23-25 27 [30][31][32][33] Differences between studies in the proportion of patients with active disease are a major factor in determining the wide variations in the reported sensitivity and accuracy of "'In scanning. Similar results have been reported with 99mTc HMPAO, although identification of various bowel segments is improved because of better image quality.…”

Technetium-99m hexamethyl propylene amine oxime-labeled leukocyte scintigraphy at three different times in active ulcerative colitis: comparison with colonoscopy and clinico-biochemical parameters in the assessment of disease extension and severity

“…In earlier studies, considerable periods of time, varying from 7 days to 30 days, elapsed between scintigraphy and reference examination [2,8,10,12,14,16,18,19]. In the present study, clinical evaluation, colonoscopy, and scintigraphy were performed within 5 days of each other to minimize the effect of variations in IBD activity over time like in study of Sans et al [20].…”

Imaging of cell trafficking in Crohn's disease

“…Several large studies have been performed to evaluate 99m Tc‐HMPAO leukocyte scintigraphy for the assessment of disease activity and extent in CD. High sensitivity and specificity values were reported (Li et al, 1992; Papos et al, 1993; Sciarretta et al, 1993; Arndt et al, 1997). Some discussion has been raised about the best imaging time.…”