Technetium-99m labelled pyrophosphate: a simple and reproducible bone scanning agent

Hosain, Parvathi

doi:10.1259/0007-1285-46-549-724

Cited by 15 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The permeability ratio of 9 9 m Tc-EHDPto 1 4 C-sucrose was 0.71 ± 0.16 (mean ± SD) (N = 10). This ratio is similar to the ratio of the diffusion coefficients of 9 9 m Tc-EHDP to 14 C-sucrose which is 0.78 and is based on molecular weights (16). We conclude that the movement of the water-soluble complexes 99m Tc-EHDP and 99m Tc-pyrophosphate is through the capillary cleft by passive free diffusion, unaffected by an active transport system.…”

Section: Methodssupporting

confidence: 60%

“…The maximal instantaneous extraction (Emax) was 0.42 ± 0.08 (mean ± SD) (N = 4); Enet was 0.36 ± 0.1 (N = 4). The outflow-dilution curve for " m T c -ethane-1-hydroxy -1 , 1 -diphosphonate (EHDP) and 14 C-sucrose is shown in Fig. 5 A.…”

Section: Methodsmentioning

confidence: 99%

“…In recent years, technetium ( 99m Tc)-labeled phosphate compounds have almost completely replaced fluoride ( 18 F) and strontium bicarbonate ( 87m Sr) as bone-scanning agents. Among the phosphate compounds that have had extensive clinical trials are 99m Tc-labeled polyphosphate (29,30), pyrophosphate (14,25), and diphosphonate (4,31,32,35,36). Uptake by bone differs between different phosphate compounds and is related to chain lengths for polyphosphate (1,19,20).…”

mentioning

confidence: 99%

See 2 more Smart Citations

The Extraction from the Blood of Phosphate Compounds by Canine Bone

Hughes¹,

Wahner²,

Kelly³

et al. 1979

Nuklearmedizin

View full text Add to dashboard Cite

SummaryUptake by bone of 99mTc-labeled pyrophosphate (PPj) and ethane-1-hydroxy-1,1-diphosphonate (EHDP) involves passage through capillaries in the Haversian system, extracellular fluid space, and membrane of osteoblasts before adsorption onto available apatite surfaces. Passage through capillaries was studied by the outflow-dilution technique in a canine tibia model in mongrel dogs. slCr-labeled albumin (nondiffusible reference tracer), sucrose (diffusible reference tracer), PPi, and EHDP were injected into the isolated nutrient tibial artery. Blood was collected from the ipsilateral femoral vein every 15 sec for 2 min. Emax, the apparent extraction at the time of the peaks of the dilution curves, is influenced little by back diffusion; for PP, Emax (mean ± SD) = 0.42 ± 0.08 (N = 4); for EHDP, Emax = 0.27 ± 0.05 (N - 10). Net extraction (apparent fractional retention by (pone at 2 min) was 0.36 ± 0.1 for PP. Emax for 8sSr chloride and 18F sodium in our laboratory is 0.69 ± 0.11 (N = 14) and 0.70 ± 0.008 (N = 9), respectively. Permeabilities (P) were calculated by PS = -Fs loge (1-Emax), where Fs = plasma flow and S = capillary surface; the ratio of P for EHDP to P for sucrose was 0.71 which is similar to the ratio of diffusion coefficients, 0.78. The data suggest that EHDP and probably also PPj pass through the capillaries by passive diffusion. As expected, the extraction through capillary walls for EHDP and PPj was lower than that for 8SSr and 18F because of their larger molecular size.

show abstract

Section: Methodssupporting

confidence: 60%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

The Extraction from the Blood of Phosphate Compounds by Canine Bone

Hughes¹,

Wahner²,

Kelly³

et al. 1979

Nuklearmedizin

View full text Add to dashboard Cite

show abstract

“…Furthermore, it is known that when large doses of polyphosphate are given to animals, some is deposited in bone (Anghileri & Miller, 1972). The finding that technetium derivatives of polyphosphates and PPi are accumulated in bone (Subramanian, McAfee, Bell, Blair, O'Mara & Ralston, 1972;Hosain, 1973;Subramanian & McAfee, 1971), a property which is currently used for skeletal scintigraphy, suggests that such transport occurs in vivo. However, although it is often 265 believed that the phosphate moiety is likely to be involved in the uptake because it binds to the mineral (Subramanian & McAfee, 1971;Jones, Francis & Davis, 1975), other possibilities, such as adsorption of the reduced tin present in the technetium complex (Cox, 1974) cannot be ex cluded.…”

Section: Introductionmentioning

confidence: 99%

Uptake by Bone of Pyrophosphate, Diphosphonates and their Technetium Derivatives

1978

View full text Add to dashboard Cite

1. The uptake of inorganic pyrophosphate (PPi) from blood to bone was investigated in the rat in vivo. 2. PPi is taken up by the bone, where it appears both as PPi and as inorganic orthophosphate (Pi). The latter is due at least partly to local hydrolysis. 3. The fraction of injected PPi taken up by bone, measured as total PPi, was in the same range as that of technetium-tin-PPi, diphosphonates, technetium-tin-ethane-1-hydroxy-1,1-diphosphonate and Pi, but lower than that of calcium. 4. The plasma half-life of PPi is in the same order of magnitude as that of technetium-tin-PPi, diphosphonates, technetium-tin-ethane-1-hydroxy-1,1-diphosphonate, Pi and calcium. 5. PPi, diphosphonates and their technetium complexes are only partly ultrafiltrable in plasma. 6. It appears that the technetium complexes behave in a similar fashion to free PPi or diphosphonate.

show abstract

“…The distribution of BBTcm-labelled pyrophosphate in tissues and organs has been analysed by, among others, HOPKINS et coll. (1973), HOSAIN (1973) and BULL et coll. (1974), who collected samples of some organs and assayed them for activity.…”

Section: Whole-body Autoradiography Of 99t~m-labelled Pyrophosphate Amentioning

confidence: 95%

Whole-Body Autoradiography of 99 Tcm-Labelled Pyrophosphate and Related Compounds in Young Rats

Rohlin

Hammarström

1976

Acta Radiologica: Therapy, Physics, Biology

View full text Add to dashboard Cite

Technetium-99m labelled pyrophosphate: a simple and reproducible bone scanning agent

Cited by 15 publications

References 6 publications

The Extraction from the Blood of Phosphate Compounds by Canine Bone

The Extraction from the Blood of Phosphate Compounds by Canine Bone

Uptake by Bone of Pyrophosphate, Diphosphonates and their Technetium Derivatives

Whole-Body Autoradiography of 99 Tcm-Labelled Pyrophosphate and Related Compounds in Young Rats

Contact Info

Product

Resources

About