Technical aspects of myocardial spect imaging with technetium-99m sestamibi

Garcia, Ernest; Cooke, C. David; Train, Kenneth F. Van; Folks, Russell; Peifer, John W.; DePuey, E. Gordon; Maddahi, Jamshid; Alazraki, Naomi P.; Galt, James R.; Ezquerra, Norberto; Ziffer, Jack A.; Areeda, J. S.; Berman, Daniel S.

doi:10.1016/0002-9149(90)90608-4

Cited by 209 publications

(48 citation statements)

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“…Quantitative analysis of perfusion was performed with the CEqual method to calculate the percent reversible and fixed perfusion defects. 14 Patients with a Ͼ5% reversible perfusion defect were selected as cases, and those without any perfusion defect were selected as controls. Left ventricular ejection fraction was calculated with the use of commercially available software.…”

Section: Single-photon Emission Computed Tomography Myocardial Perfusmentioning

confidence: 99%

Metabolomic Identification of Novel Biomarkers of Myocardial Ischemia

et al. 2005

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Background-Recognition of myocardial ischemia is critical both for the diagnosis of coronary artery disease and the selection and evaluation of therapy. Recent advances in proteomic and metabolic profiling technologies may offer the possibility of identifying novel biomarkers and pathways activated in myocardial ischemia. Methods and Results-Blood samples were obtained before and after exercise stress testing from 36 patients, 18 of whom demonstrated inducible ischemia (cases) and 18 of whom did not (controls). Plasma was fractionated by liquid chromatography, and profiling of analytes was performed with a high-sensitivity electrospray triple-quadrupole mass spectrometer under selected reaction monitoring conditions. Lactic acid and metabolites involved in skeletal muscle AMP catabolism increased after exercise in both cases and controls. In contrast, there was significant discordant regulation of multiple metabolites that either increased or decreased in cases but remained unchanged in controls.Functional pathway trend analysis with the use of novel software revealed that 6 members of the citric acid pathway were among the 23 most changed metabolites in cases (adjusted Pϭ0.04

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Section: Single-photon Emission Computed Tomography Myocardial Perfusmentioning

confidence: 99%

Metabolomic Identification of Novel Biomarkers of Myocardial Ischemia

et al. 2005

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“…Target areas were defined as segments of myocardial perfusion < 40% based on the studies of Garcia,et al,20) and the proportion of fixed defects = the target areas / the total area of the myocardium × 100%, which is generated automatically by our image processing system (Siemens AG). Stem cell preparation and transplantation: Patients in the transplantation groups underwent bone marrow aspiration (80 to 100 mL) from the bilateral posterior superior iliac spines under sedation and local anesthesia (bone marrow aspirate in the BMMC group was obtained in the morning of the cell transplantation day, while the procedure had been performed about 14 days before in the BMSC group).…”

Section: Data Collectionmentioning

confidence: 99%

A Randomized Comparative Study on the Efficacy of Intracoronary Infusion of Autologous Bone Marrow Mononuclear Cells and Mesenchymal Stem Cells in Patients With Dilated Cardiomyopathy

et al. 2017

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SummaryStem cell therapy has shown therapeutic benefit in dilated cardiomyopathy (DCM), but doubt remains about the most appropriate stem cell subpopulation. The current study compared the efficacy of intracoronary administration of bone marrow mononuclear cells (BMMC) or mesenchymal stem cells (BMSC) in patients with DCM.Fifty-three patients with DCM and reduced (< 40%) left ventricular ejection fraction (LVEF), were randomized to intracoronary infusion of BMMC (BMMC group, n = 16) or BMSC (BMSC group, n = 17) or equal volume normal saline (CTRL group, n = 20). LVEF, New York Heart Association (NYHA) class, left ventricular end-diastolic diameter (LVEDd), and myocardial perfusion were assessed at baseline and at 3-month and 12-month follow-ups. Major adverse cardiovascular events (MACE) were also recorded.At the 3-month follow-up, LVEF, NYHA class, and myocardial perfusion had improved significantly in the BMSC group (P = 0.004, 0.020 and 0.019, respectively) along with significant changes in LVEF and NYHA class in the BMMC group compared with CTRL (P = 0.042 and 0.047, respectively), however, LVEDd remained unchanged. In comparison with CTRL, LVEF, NYHA class, and myocardial perfusion improved significantly in the BMSC group at the 12-month follow-up (P = 0.005, 0.050 and 0.038 respectively), but not in the BMMC group (P > 0.05). There were no significant differences between the transplantation groups during follow-up (P > 0.05). There were no differences in MACE among the 3 groups (P = 0.817).Intracoronary bone marrow stem cell transplantation in DCM is safe and effective, while BMSC and BMMC infusion possess comparable effectiveness. (Int Heart J 2017; 58: 238-244) Key words: Heart failure, Therapeutics, Cytological techniques, Transplantation D ilated cardiomyopathy (DCM), characterized by ventricular dilatation and impaired systolic function of the left or both ventricles of incompletely understood pathogenesis, is the most common form of non-ischemic cardiomyopathy.1,2) Current therapies for the condition, such as beta-blockers, angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor antagonists (ARBs), and mechanotherapy seek to reduce the rate at which myocardial damage accrues but do not have regenerative potential. Thus, new therapeutic procedures for this condition are required for this significant, unmet clinical need.The exploration and development of regenerative treatment constitutes a promising therapeutic option for nonischemic cardiomyopathy.3,4) Intracoronary administration of autologous bone marrow stem cells (BMC) has proved to be safe and has shown significant improvement of cardiac function in the treatment of post-infarct and chronic ischemic models in both preclinical and clinical settings. [5][6][7][8] Because severely reduced coronary flow reserve and impaired microvascular function have been observed in patients with DCM, 9,10) several clinical studies have applied cell therapy to these patients, 4,[11][12][13][14] despite much controversy concerning the underlying mech...

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“…Gated projection data sets were converted to summed non-gated data and vertical long axis, horizontal long axis, and short-axis images were reconstructed by CEqual method. This method is highly reproducible and can be used to interpret temporal changes in myocardial perfusion (10,11).…”

Section: Image Analysismentioning

confidence: 99%

6.54

Kaya

2007

Journal of Nuclear Cardiology

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Technical aspects of myocardial spect imaging with technetium-99m sestamibi

Cited by 209 publications

References 2 publications

Metabolomic Identification of Novel Biomarkers of Myocardial Ischemia

Metabolomic Identification of Novel Biomarkers of Myocardial Ischemia

A Randomized Comparative Study on the Efficacy of Intracoronary Infusion of Autologous Bone Marrow Mononuclear Cells and Mesenchymal Stem Cells in Patients With Dilated Cardiomyopathy

6.54

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