Technical assessment of whole body angiography and cardiac function within a single MRI examination

Gandy, Stephen J.; Lambert, Matthew; Belch, J. J. F.; Cavin, Ian; Crowe, E.; Littleford, Roberta; Macfarlane, Jennifer A.; Matthew, Shona Z.; Martin, Patricia; Nicholas, R. Stephen; Struthers, Allan D.; Sullivan, Frank; Waugh, Shelley A.; White, Richard D.; Weir-McCall, JR; Houston, J. Graeme

doi:10.1016/j.crad.2015.02.003

Cited by 14 publications

(21 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MRI protocol has been described in detail elsewhere (15). In brief, imaging was performed using a 3-T Magnetom Trio Scanner (Siemens, Erlangen, Germany).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Left Ventricular Noncompaction

Weir‐McCall

Yeap

Papagiorcopulo

et al. 2016

Journal of the American College of Cardiology

125

View full text Add to dashboard Cite

BackgroundThere is considerable overlap between left ventricular noncompaction (LVNC) and other cardiomyopathies. LVNC has been reported in up to 40% of the general population, raising questions about whether it is a distinct pathological entity, a remodeling epiphenomenon, or merely an anatomical phenotype.ObjectivesThe authors determined the prevalence and predictors of LVNC in a healthy population using 4 cardiac magnetic resonance imaging diagnostic criteria.MethodsVolunteers >40 years of age (N = 1,651) with no history of cardiovascular disease (CVD), a 10-year risk of CVD < 20%, and a B-type natriuretic peptide level greater than their gender-specific median underwent magnetic resonance imaging scan as part of the TASCFORCE (Tayside Screening for Cardiac Events) study. LVNC ratios were measured on the horizontal and vertical long axis cine sequences. All individuals with a noncompaction ratio of ≥2 underwent short axis systolic and diastolic LVNC ratio measurements, and quantification of noncompacted and compacted myocardial mass ratios. Those who met all 4 criteria were considered to have LVNC.ResultsOf 1,480 participants analyzed, 219 (14.8%) met ≥1 diagnostic criterion for LVNC, 117 (7.9%) met 2 criteria, 63 (4.3%) met 3 criteria, and 19 (1.3%) met all 4 diagnostic criteria. There was no difference in demographic or allometric measures between those with and without LVNC. Long axis noncompaction ratios were the least specific, with current diagnostic criteria positive in 219 (14.8%), whereas the noncompacted to compacted myocardial mass ratio was the most specific, only being met in 61 (4.4%).ConclusionsA significant proportion of an asymptomatic population free from CVD satisfy all currently used cardiac magnetic resonance imaging diagnostic criteria for LVNC, suggesting that those criteria have poor specificity for LVNC, or that LVNC is an anatomical phenotype rather than a distinct cardiomyopathy.

show abstract

“…The MRI protocol has been described in detail elsewhere (15). In brief, imaging was performed using a 3-T Magnetom Trio Scanner (Siemens, Erlangen, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…LV mass and volume quantification was performed as previously described (15). Values were normalized to height 1.7 .…”

Section: Methodsmentioning

confidence: 99%

Left Ventricular Noncompaction

Weir‐McCall

Yeap

Papagiorcopulo

et al. 2016

Journal of the American College of Cardiology

125

View full text Add to dashboard Cite

show abstract

“…From this, a “per decade” change in each variable was calculated, based on the assumption that the changes were linear with age. A formal assessment of intra‐ and interobserver repeatability has not been presented since this is reported elsewhere 22. However, reasonable estimates of interobserver variation can be extracted from the data generated by different segmentation observers because each of the respective cohorts were age‐matched, gender‐matched, and normalized to BSA.…”

Section: Methodsmentioning

confidence: 99%

“…The MR protocol has been described in detail elsewhere, 22 but in brief imaging was performed in the head-first supine orientation using a 3T [102x32] Scanner (Magnetom Trio, Siemens, Erlangen, Germany). A body matrix radiofrequency (RF) coil (six elements) was used in combination with a spine array (up to 24 elements).…”

Section: Methodsmentioning

confidence: 99%

3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study

Gandy

Lambert

Belch

et al. 2016

Magnetic Resonance Imaging

View full text Add to dashboard Cite

PurposeTo scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T.Materials and MethodsA population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady‐state free precession (SSFP) LV data in the short‐axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis.ResultsMean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m2, end systolic volume index (ESVI) = 22 ± 7 ml/m2, stroke volume index (SVI) = 49 ± 8 ml/m2, and LV mass index (LVMI) = 55 ± 12 g/m2. The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m2, ESVI 21v25 ml/m2, SVI 46v52 ml/m2, LVMI 49v64 g/m2, all P < 0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: –2.9 ± 1.3 ml/m2, females: –3.1 ± 0.8 ml/m2; ESVI males: –1.3 ± 0.7 ml/m2, females: –1.7 ± 0.5 ml/m2; SVI males: –1.7 ± 0.9 ml/m2, females: –1.4 ± 0.6 ml/m2; LVMI males: –1.6 ± 1.1 g/m2, females: –0.2 ± 0.6 g/m2) but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age.ConclusionLV reference ranges are provided in this population‐based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population‐based MR research studies that involve the use of 3.0T MRI scanners. J. Magn. Reson. Imaging 2016;44:1186–1196.

show abstract

“…18 In brief, the scans were performed on a 32 radio frequency (RF) receiver channel, 3-T MRI scanner (Magnetom ® Trio; Siemens, Erlangen, Germany). For whole-body coverage, a combination of six RF coils, including head matrix, neck matrix, spine matrix, 2 body matrices and peripheral angiography phased-array RF surface coils, were used.…”

Section: Methodsmentioning

confidence: 99%

Whole-body cardiovascular MRI for the comparison of atherosclerotic burden and cardiac remodelling in healthy South Asian and European adults

Weir‐McCall¹,

Cassidy²,

Belch³

et al. 2016

BJR

View full text Add to dashboard Cite

Objective:To determine the feasibility of using whole-body cardiovascular MRI (WB-CVMR) to compare South Asians (SAs)—a population known to have a higher risk of cardiovascular disease (CVD) but paradoxically lower prevalence of peripheral arterial disease—and Western Europeans (WEs).Methods:19 SAs and 38 age-, gender- and body mass index-matched WEs were recruited. All were aged 40 years and over, free from CVD and with a 10-year risk of CVD <20% as assessed by the adult treatment panel (ATP) III risk score. WB-CVMR was performed, comprising a whole-body angiogram (WBA) and cardiac MR (CMR), on a 3-T MRI scanner (Magnetom® Trio; Siemens, Erlangen, Germany) following dual-phase injection of gadolinium-based contrast agent. A standardized atheroma score (SAS) was calculated from the WBA while indexed left ventricular mass and volumes were calculated from the CMR.Results:SAs exhibited a significantly lower iliofemoral atheroma burden (regional SAS 0.0 ± 0.0 vs 1.9 ± 6.9, p = 0.048) and a trend towards lower overall atheroma burden (whole-body SAS 0.7 ± 0.8 vs 1.8 ± 2.3, p = 0.1). They had significantly lower indexed left ventricular mass (46.9 ± 11.8 vs 56.9 ± 13.4 ml m−2, p = 0.008), end diastolic volume (63.9 ± 10.4 vs 75.2 ± 11.4 ml m−2, p=0.001), end systolic volume (20.5 ± 6.1 vs 24.6 ± 6.8 ml m−2, p = 0.03) and stroke volume (43.4 ± 6.6 vs 50.6 ± 7.9 ml m−2, p = 0.001), but with no significant difference in ejection fraction, mass-volume ratio or global functioning index. These differences persisted after accounting for CVD risk factors.Conclusion:WB-CVMR can quantify cardiac and atheroma burden and can detect differences in these metrics between ethnic groups that, if validated, may suggest that the paradoxical high risk of CVD compared with PVD risk may be due to an adverse cardiac haemodynamic status incurred by the smaller heart rather than atherosclerosis.Advances in knowledge:WB-CVMR can be used to stratify and compare disease between ethnicities.

show abstract

Technical assessment of whole body angiography and cardiac function within a single MRI examination

Cited by 14 publications

References 31 publications

Left Ventricular Noncompaction

Left Ventricular Noncompaction

3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study

Whole-body cardiovascular MRI for the comparison of atherosclerotic burden and cardiac remodelling in healthy South Asian and European adults

Contact Info

Product

Resources

About