Techniques for the discovery and evaluation of drugs against alopecia

Semalty, Ajay; Semalty, Mona; Joshi, Gopal Krishna; Rawat, Mahiraj Singh

doi:10.1517/17460441.2011.553831

Cited by 5 publications

(2 citation statements)

References 56 publications

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“…Alopecia (baldness) may lead to psychological distress (Hawkshaw et al, 2018 ) and is a common problem in cosmetics and primary health practice (Semalty et al, 2011 ). Hair loss individuals often inquire if nutritional supplements can help restore hair growth or arrest disease progression (Guo & Katta, 2017 ).…”

Section: The Beneficial Health Effects Of Applesmentioning

confidence: 99%

Does an apple a day keep away diseases? Evidence and mechanism of action

Zhang

Zeng

Zhang

et al. 2023

Food Science & Nutrition

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Apples and their products exemplify the recently reemphasized link between dietary fruit intake and the alleviation of human disease. Their consumption does indeed improve human health due to their high phytochemical content. To identify potentially relevant articles from clinical trials, some epidemiological studies and meta‐analyses, and in vitro and in vivo studies (cell cultures and animal models), PubMed was searched from January 1, 2012, to May 15, 2022. This review summarized the potential effects of apple and apple products (juices, puree, pomace, dried apples, extracts rich in apple bioactives and single apple bioactives) on health. Apples and apple products have protective effects against cardiovascular diseases, cancer, as well as mild cognitive impairment and promote hair growth, healing of burn wounds, improve the oral environment, prevent niacin‐induced skin flushing, promote the relief of UV‐induced skin pigmentation, and improve the symptoms of atopic dermatitis as well as cedar hay fever among others. These effects are associated with various mechanisms, such as vascular endothelial protection, blood lipids lowering, anti‐inflammatory, antioxidant, antiapoptotic, anti‐invasion, and antimetastatic effects. Meanwhile, it has provided an important reference for the application and development of medicine, nutrition, and other fields.

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Section: The Beneficial Health Effects Of Applesmentioning

confidence: 99%

Does an apple a day keep away diseases? Evidence and mechanism of action

Zhang

Zeng

Zhang

et al. 2023

Food Science & Nutrition

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“…It is widely considered that topical application of active agents is superior to oral or parenteral administration of drugs for AGA [81]. The ideal therapeutic would be a cream or lotion that one could rub on one’s head in the morning after one’s shower.…”

Section: Androgenic Alopeciamentioning

confidence: 99%

Drug discovery for alopecia: gone today, hair tomorrow

Santos

Avci

Hamblin

2015

Expert Opinion on Drug Discovery

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Introduction Hair loss or alopecia affects the majority of the population at some time in their life, and increasingly, sufferers are demanding treatment. Three main types of alopecia (androgenic [AGA], areata [AA] and chemotherapy-induced [CIA]) are very different, and have their own laboratory models and separate drug-discovery efforts. Areas covered In this article, the authors review the biology of hair, hair follicle (HF) cycling, stem cells and signaling pathways. AGA, due to dihydrotesterone, is treated by 5-α reductase inhibitors, androgen receptor blockers and ATP-sensitive potassium channel-openers. AA, which involves attack by CD8+NK group 2D-positive (NKG2D+) T cells, is treated with immunosuppressives, biologics and JAK inhibitors. Meanwhile, CIA is treated by apoptosis inhibitors, cytokines and topical immunotherapy. Expert opinion The desire to treat alopecia with an easy topical preparation is expected to grow with time, particularly with an increasing aging population. The discovery of epidermal stem cells in the HF has given new life to the search for a cure for baldness. Drug discovery efforts are being increasingly centered on these stem cells, boosting the hair cycle and reversing miniaturization of HF. Better understanding of the molecular mechanisms underlying the immune attack in AA will yield new drugs. New discoveries in HF neogenesis and low-level light therapy will undoubtedly have a role to play.

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