2021
DOI: 10.17691/stm2021.13.1.05
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Technology for Repairing Osteomyelitic Bone Defects Using Autologous Mesenchymal Stromal Cells on a Collagen Matrix in Experiment

Abstract: The aim of the study was to develop a technology for repairing an osteomyelitic bone defect using autologous adipose tissue mesenchymal stromal cells (MSCs) bound to a collagen matrix and to test the efficacy of this technique. Materials and Methods. The study was carried out with 17 rabbits. A bone defect was created using a milling cutter applied to the proximal third of the leg. The wound (8.0×4.0 mm and a depth of 4.0 mm) involved the periosteum, cortical layer, and cancellous substance. Staphylococcus aur… Show more

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“…In this context, the potential of adipose-derived stem cells (ADSCs) has garnered significant interest. ADSCs, known for their regenerative capabilities and immunomodulatory properties, have shown promise in enhancing the efficacy of antibiotic therapies [ 5 6 ]. Recent studies have explored the use of ADSCs in combination with antibiotics, focusing on their dual role – direct antimicrobial action and immunomodulation [ 7 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…In this context, the potential of adipose-derived stem cells (ADSCs) has garnered significant interest. ADSCs, known for their regenerative capabilities and immunomodulatory properties, have shown promise in enhancing the efficacy of antibiotic therapies [ 5 6 ]. Recent studies have explored the use of ADSCs in combination with antibiotics, focusing on their dual role – direct antimicrobial action and immunomodulation [ 7 8 ].…”
Section: Introductionmentioning
confidence: 99%