Mediation is a crucial element in the learning process, especially in a virtual environment, whether it corresponds to formal, non-formal, or informal education. This paper aims to expose the research on mediation and learning in virtual environments published between 2015 and 2020. A total of 299 articles were identified that address the topic of mediation and learning in virtual environments from different fields and approaches. The results that respond to the research questions are presented. The study was carried out with the Web of Science (WOS) and Scopus databases, and inclusion and exclusion criteria were applied to obtain the articles under study. The Systematic Literature Mapping (SLM) method was used to answer questions raised for analysis. Information was extracted from the articles regarding the method used, the most cited articles, geographical distribution of the authors by country, the journals and impact factor, type of mediation, and finally, the trends and spaces where mediation takes place. The results show studies tending toward technological mediation and factors such as interaction, collaboration, communication, and discussion, among others. The practical implications are oriented to show the mediating factor from the pedagogical and technological perspectives and its contribution to achieve meaningful learning.