Tectal Control of Spinal Cord Activity:Neuroanatomical Demonstration of Pathways Connecting the Superior Colliculus with theCervical Spinal Cord Grey

Mf, Huerta; Jk, Harting

doi:10.1016/s0079-6123(08)64135-7

Cited by 105 publications

(44 citation statements)

References 72 publications

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“…In contrast to the PPRF data, stimulation of certain regions of the nucleus reticularis gigantocellularis (NRG) produces movements (Sprague and Chambers 1954;Quessy and Freedman 2004;Sasaki et al 2004) with an attenuated VOR gain (Quessy and Freedman 2004). The NRG resides caudal to the abducens nucleus (Peterson et al 1975;Tohyama et al 1979;Huerta and Harting 1982;Robinson et al 1994) and, compared to the PPRF, has a higher density of projections to the neck motoneurons (Tohyama et al 1979;Grantyn and Berthoz 1988). Quessy and Freedman (2004) assumed that they activated neurons within the pathway controlling only head movements and, therefore, interpreted the observed eye movement as VOR gain readout.…”

Section: Status Of the Vor Gain: Comparison With Previous Studiesmentioning

confidence: 99%

Coordination of eye and head components of movements evoked by stimulation of the paramedian pontine reticular formation

2008

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Constant frequency microstimulation of the paramedian pontine reticular formation (PPRF) in head-restrained monkeys evokes a constant velocity eye movement. Since the PPRF receives significant projections from structures that control coordinated eye-head movements, we asked whether stimulation of the pontine reticular formation in the head-unrestrained animal generates a combined eye-head movement or only an eye movement. Microstimulation of most sites yielded a constant-velocity gaze shift executed as a coordinated eye-head movement, although eye-only movements were evoked from some sites. The eye and head contributions to the stimulationevoked movements varied across stimulation sites and were drastically different from the lawful relationship observed for visually-guided gaze shifts. These results indicate that the microstimulation activated elements that issued movement commands to the extraocular and, for most sites, neck motoneurons. In addition, the stimulation-evoked changes in gaze were similar in the head-restrained and head-unrestrained conditions despite the assortment of eye and head contributions, suggesting that the vestibuloocular reflex (VOR) gain must be near unity during the coordinated eye-head movements evoked by stimulation of the PPRF. These findings contrast the attenuation of VOR gain associated with visually-guided gaze shifts and suggest that the vestibulo-ocular pathway processes volitional and PPRF stimulation-evoked gaze shifts differently.

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Section: Status Of the Vor Gain: Comparison With Previous Studiesmentioning

confidence: 99%

Coordination of eye and head components of movements evoked by stimulation of the paramedian pontine reticular formation

2008

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“…The superficial layers of the SC (sSC) receive retinotopically organized visual inputs (Cynader and Berman, 1972), whereas the deeper layers (dSC) send descending commands for the initiation of orienting movements (Huerta and Harting, 1982;May, 2005). More than three decades ago, studies showed that movement vectors are topographically represented in the dSC (Robinson, 1972;Schiller and Stryker, 1972;Wurtz and Goldberg, 1972) and that this motor map is in register with the map of the visual field in sSC.…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal Profiles of Field Potentials in Mouse Superior Colliculus Analyzed by Multichannel Recording

Phongphanphanee¹,

Kaneda²,

Isa³

2008

J. Neurosci.

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The onset and vector of orienting behaviors, such as saccades, are controlled by commands that descend from a population of neurons in deep layers of the superior colliculus (dSC). In this study, to characterize the role of the collicular local circuitry that generates the spatiotemporal pattern of command activity in the dSC neuronal population, responses evoked by single-pulse electrical stimulation in superficial layers of the superior colliculus (sSC) were analyzed by a 64-channel field potential recording system (planar electrode, 8 ϫ 8 pattern; 150 m interelectrode spacing) in slices obtained from 16-to 22-d-old mice. A negative field potential with short latency and short duration spatially restricted to the recording sites in sSC was evoked adjacent to the stimulation site. After bath application of 10 M bicuculline, the same stimulus induced a large negative field response with long duration that spread from sSC to dSC. The dSC potential initially showed a positive response, presumably because of reversal of the negative potential that originated in sSC, and then a long negative response that spread horizontally as far as 1 mm. These responses disappeared after application of an NMDA receptor antagonist, 2-amino-5-phosphonovelarate, indicating that NMDA receptors have an important role in the generation of these responses. Simultaneous whole-cell patch-clamp recordings showed that the long-lasting negative field potentials corresponded to the depolarization accompanying burst spike activity of SC neurons. The present study revealed an extensive excitatory network in the dSC that may contribute to the generation of activity by a large population of neurons that discharge before a saccade.

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“…There is, however, anatomic evidence that two distinct descending pathways originate from different layers in the stratum griseum intermediale: an indirect pathway reaching oculomotor centers and a direct pathway reaching the spinal cord (Harting 1977;Huerta and Harting 1982;May and Porter 1992). Importantly, the model proposed by May and Porter (1992) includes a collateral input from the direct pathway to oculomotor centers in the reticular formation.…”

Section: Discussionmentioning

confidence: 99%

Target modality determines eye-head coordination in nonhuman primates: implications for gaze control

Populin

Rajala²

2011

Journal of Neurophysiology

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Tectal Control of Spinal Cord Activity:Neuroanatomical Demonstration of Pathways Connecting the Superior Colliculus with theCervical Spinal Cord Grey

Cited by 105 publications

References 72 publications

Coordination of eye and head components of movements evoked by stimulation of the paramedian pontine reticular formation

Coordination of eye and head components of movements evoked by stimulation of the paramedian pontine reticular formation

Spatiotemporal Profiles of Field Potentials in Mouse Superior Colliculus Analyzed by Multichannel Recording

Target modality determines eye-head coordination in nonhuman primates: implications for gaze control

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