The present paper is written to bring to light a dichotomy that is noted in a naturally deformed rock, where the sense of shear inferred from quartz shape preferred orientation (SPO) is opposite to that deciphered from the crystallographic preferred orientation (CPO). Microstructural and quartz CPO data (obtained through SEM-EBSD analysis) from a quartz vein hosted in sinistrally sheared mylonitized granite of Gadwal region (Dharwar Craton) are presented. The vein thin section is prepared parallel to the kinematic reference frame (XZ section of the strain ellipsoid) using field-based information, which allows determination of sense of shear using microstructures. Three domains viz. Domain-I, II and III are identified in the rock thin section with grain size being 300-180 µm, 70-35 µm, and <20 µm, respectively. Of these, quartz grains of Domain-II show a well-defined quartz oblique grain shape fabric, which is indicative of dextral sense of shear. However, quartz CPO from the same Domain-II, as well as Domains-I and III, consistently shows a sinistral sense of shear; the latter complements the kinematics noted from the host rock mylonite. The dichotomy noted from Domain-II indicates that there maybe pitfalls in direct interpretation of kinematics based exclusively on quartz SPO analysis. Hence, caution must be exercised while extrapolating microscale kinematics based on quartz SPO to the regional scale.