Teicoplanin-loaded chitosan-PEO nanofibers for local antibiotic delivery and wound healing

Amiri, Nafise; Ajami, Saeed; Shahroodi, Azadeh; Jannatabadi, Nafise; Darban, Shahrzad Amiri; Bazzaz, Bibi Sedigheh Fazly; Pishavar, Elham; Kalalinia, Fatemeh; Movaffagh, Jebrail

doi:10.1016/j.ijbiomac.2020.06.195

Cited by 115 publications

(77 citation statements)

References 55 publications

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“…The values of n were below 0.45, which indicated that the SQ, SQ.Cu 2+ and SQ.Fe 3+ release from the cr(PVA/Ch) mats occurred through the Fickian diffusion mechanism. The obtained results are in conformity with previous reports on the mechanism of drug release from Ch-containing fibrous mats [ 27 , 69 , 70 ].…”

Section: Resultssupporting

confidence: 92%

8-Hydroxyquinoline-5-Sulfonic Acid-Containing Poly(Vinyl Alcohol)/Chitosan Electrospun Materials and Their Cu2+ and Fe3+ Complexes: Preparation, Antibacterial, Antifungal and Antitumor Activities

et al. 2021

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Novel poly(vinyl alcohol) (PVA)/chitosan (Ch)-based fibrous materials containing an ionizable model drug, 8-hydroxyquinoline-5-sulfonic acid (SQ), were successfully fabricated by electrospinning. Complexes between the components of the crosslinked PVA/Ch/SQ mats and Cu2+ and Fe3+ ions were formed. The coordination of these ions in the mats was examined by electron paramagnetic resonance spectroscopy (EPR). The microbiological screening against S. aureus and C. albicans revealed that both the incorporation of SQ in the mats and the complexation with Cu2+ and Fe3+ imparted to these materials antibacterial and antifungal activities. Moreover, the SQ-containing mats and their complexes displayed good cytotoxicity against human cervical HeLa tumor cells. The most prominent was the cytotoxicity of the Cu2+ complex of the mats. The combined antibacterial, antifungal and in vitro antitumor activities render these novel materials promising candidates for wound dressing applications and for application in the local treatment of cervical tumors.

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Section: Resultssupporting

confidence: 92%

8-Hydroxyquinoline-5-Sulfonic Acid-Containing Poly(Vinyl Alcohol)/Chitosan Electrospun Materials and Their Cu2+ and Fe3+ Complexes: Preparation, Antibacterial, Antifungal and Antitumor Activities

et al. 2021

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“…Additionally, hydrogels comprising this bioactive polymer could counteract the factors impairing healing processes by anti-inflammatory and antimicrobial actions [ 33 ]. Among all biomaterials, chitosan is one of the most frequently used ingredients in hydrogel preparation [ 34 , 35 ]; however, other formulations are also reported such as nanofibers [ 36 ] and nanoparticles [ 37 ]. Moreover, chitosan is often used as a coating material for vesicles [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control

et al. 2021

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Burns and other skin injuries are growing concerns as well as challenges in an era of antimicrobial resistance. Novel treatment options to improve the prevention and eradication of infectious skin biofilm-producing pathogens, while enhancing wound healing, are urgently needed for the timely treatment of infection-prone injuries. Treatment of acute skin injuries requires tailoring of formulation to assure both proper skin retention and the appropriate release of incorporated antimicrobials. The challenge remains to formulate antimicrobials with low water solubility, which often requires carriers as the primary vehicle, followed by a secondary skin-friendly vehicle. We focused on widely used chlorhexidine formulated in the chitosan-infused nanocarriers, chitosomes, incorporated into chitosan hydrogel for improved treatment of skin injuries. To prove our hypothesis, lipid nanocarriers and chitosan-comprising nanocarriers (≈250 nm) with membrane-active antimicrobial chlorhexidine were optimized and incorporated into chitosan hydrogel. The biological and antibacterial effects of both vesicles and a vesicles-in-hydrogel system were evaluated. The chitosomes-in-chitosan hydrogel formulation demonstrated promising physical properties and were proven safe. Additionally, the chitosan-based systems, both chitosomes and chitosan hydrogel, showed an improved antimicrobial effect against S. aureus and S. epidermidis compared to the formulations without chitosan. The novel formulation could serve as a foundation for infection prevention and bacterial eradication in acute wounds.

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“…Ahire et al [129] reported that kanamycin-loaded hyaluronic acid/PEO-based electrospun textiles inhibited the growth of Listeria monocytogenes by 62% compared to textiles without the antibiotic. Amiri et al [130] reported that teicoplanin-loaded chitosan/PEO-based electrospun textiles showed sustained releases of the antibiotic in vitro up to 12 days, and their antibacterial activities were 1.5 to 2 times higher than that of free teicoplanin. The textiles showed no cytotoxicity to human fibroblasts and demonstrated better wound closure in a rat full thickness wound model.…”

Section: Wound Healingmentioning

confidence: 99%

Electrospun Polysaccharidic Textiles for Biomedical Applications

Poshina

Otsuka

2021

Textiles

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Recent developments in electrospinning technology have enabled the commercial-scale production of nonwoven fabrics from synthetic and natural polymers. Since the early 2000s, polysaccharides and their derivatives have been recognized as promising raw materials for electrospinning, and their electrospun textiles have attracted increasing attention for their diverse potential applications. In particular, their biomedical applications have been spotlighted thanks to their “green” aspects, e.g., abundance in nature, biocompatibility, and biodegradability. This review focuses on three main research topics in the biomedical applications of electrospun polysaccharidic textiles: (i) delivery of therapeutic molecules, (ii) tissue engineering, and (iii) wound healing, and discusses recent progress and prospects.

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Teicoplanin-loaded chitosan-PEO nanofibers for local antibiotic delivery and wound healing

Cited by 115 publications

References 55 publications

8-Hydroxyquinoline-5-Sulfonic Acid-Containing Poly(Vinyl Alcohol)/Chitosan Electrospun Materials and Their Cu2+ and Fe3+ Complexes: Preparation, Antibacterial, Antifungal and Antitumor Activities

8-Hydroxyquinoline-5-Sulfonic Acid-Containing Poly(Vinyl Alcohol)/Chitosan Electrospun Materials and Their Cu2+ and Fe3+ Complexes: Preparation, Antibacterial, Antifungal and Antitumor Activities

Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control

Electrospun Polysaccharidic Textiles for Biomedical Applications

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